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Progress towards drug discovery for Friedreich’s Ataxia: Identifying synthetic oligonucleotides that more potently activate expression of human frataxin protein

Bioorganic & Medicinal Chemistry(2020)10.1016/j.bmc.2020.115472Source: DataRank Database

Progress towards drug discovery for Friedreich’s Ataxia: Identifying synthetic oligonucleotides that more potently activate expression of human frataxin protein is a research paper published in Bioorganic & Medicinal Chemistry (2020). On theSindex it has a DataRank of 0. It has been cited 17 times.

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Open Access17 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 1.13)OA: greenTopics (50)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Johnathan Wong ORCID,Thahza P. Prakash,Frank Rigo ORCID,Yanjie Li ORCID,Марек Напиерала ORCID

Live enrichment

PubMed:32279920 PMC:PMC7217746 OpenAlex:https://openalex.org/W3015075087

NINDS NIH HHS

Grant: R01 NS081366

NIGMS NIH HHS

Grant: R35 GM118103

National Institutes of Health

Grant: 2R01NS081366-06

GAA REPEATS INDUCED EPIGENETIC SILENCING IN FRIEDREICH'S ATAXIA

National Institutes of Health

Grant: 5R35GM118103-02

Recognition of Cellular Targets by single and double-stranded nucleic acids

National Institute of General Medical Sciences

FWCI

1.13

Citation Percentile

0.7%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

greenLicense: Elsevier TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7217746

publisherhttps://api.elsevier.com/content/article/PII:S0968089620302868?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0968089620302868?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.bmc.2020.115472

Fields of Study

Genetic Neurodegenerative DiseasesMitochondrial Function and PathologyGenetics and Neurodevelopmental Disorders0301 basic medicine0303 health sciences03 medical and health sciencesCells, CulturedDose-Response Relationship, DrugDrug DiscoveryFriedreich AtaxiaHumansIron-Binding ProteinsMolecular StructureOligonucleotides, AntisenseStructure-Activity RelationshipFrataxin

MeSH Terms

FrataxinCells, CulturedDose-Response Relationship, DrugFriedreich AtaxiaHumansStructure-Activity RelationshipMolecular StructureOligonucleotides, AntisenseIron-Binding ProteinsDrug Discovery

Keywords

FrataxinChemistryAtaxiaDrug discoveryOligonucleotideDrugBiochemistryComputational biologyPharmacologyIron-binding proteinsDNAGeneNeuroscienceRNAAntisense oligonucleotideGene ActivationFriedreich’s AtaxiaDose-Response Relationship, DrugMolecular StructureOligonucleotides, AntisenseStructure-Activity RelationshipFriedreich AtaxiaHumansCells, Cultured

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Progress towards drug discovery for Friedreich’s Ataxia: Identifying synthetic oligonucleotides that more potently activate expression of human frataxin protein

FAIR Checklist

Authors (7)

Funding (5 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)