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Combination nitazoxanide and auranofin treatment has synergistic anticancer activity in anaplastic thyroid cancer through enhanced activation of oxidative stress that leads to apoptosis

Cancer Letters(2025)10.1016/j.canlet.2025.217990Source: DataRank Database

Combination nitazoxanide and auranofin treatment has synergistic anticancer activity in anaplastic thyroid cancer through enhanced activation of oxidative stress that leads to apoptosis is a research paper published in Cancer Letters (2025). On theSindex it has a DataRank of 0. It has been cited 5 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access5 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 2.38)OA: greenTopics (57)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (13)

Tejinder Pal Khaket ORCID,Viswanath Gunda,Zhongyue Yang ORCID,Jiangnan Hu ORCID,Eden Demissie Alamaw

Live enrichment

PubMed:40834985 OpenAlex:https://openalex.org/W4413326236

National Institutes of Health

Grant: ZIABC011286-09

US Department of Defense

Grant: HT94252310625

Intramural NIH HHS

Grant: ZIA BC011286

Stanford University

National Cancer Institute

FWCI

2.38

Citation Percentile

0.9%

Citation Trend

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12670439/

publisherhttps://api.elsevier.com/content/article/PII:S0304383525005609?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0304383525005609?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.canlet.2025.217990

Fields of Study

Redox biology and oxidative stressFree Radicals and AntioxidantsAntioxidant Activity and Oxidative StressHumansNitro CompoundsApoptosisThiazolesAuranofinDrug SynergismAnimalsCell Line, TumorOxidative StressThyroid Carcinoma, AnaplasticCell ProliferationXenograft Model Antitumor AssaysAntineoplastic Combined Chemotherapy ProtocolsThyroid NeoplasmsReactive Oxygen SpeciesMice, NudeMiceCell MovementFemale

MeSH Terms

AnimalsAntineoplastic Combined Chemotherapy ProtocolsAuranofinCell MovementDrug SynergismFemaleHumansMice, NudeNitro CompoundsThiazolesThyroid NeoplasmsApoptosisReactive Oxygen SpeciesOxidative StressXenograft Model Antitumor AssaysCell Line, TumorCell ProliferationMiceThyroid Carcinoma, Anaplastic

Keywords

AuranofinNitazoxanideOxidative stressApoptosisAnaplastic thyroid cancerMedicineCancerCancer researchPharmacologyThyroid cancerInternal medicineChemistryBiochemistrySynergismCell deathCombination therapy

Sustainable Development Goals

SDG 0: Good health and well-being

Related Papers (1)

PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway–Deficient Acute Myeloid Leukemia

N/A

0.316DataRank · unranked

Cancer Research Communications(2025)

co-cited

10.1158/2767-9764.crc-24-0260