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FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N 6 -Methyladenosine RNA Demethylase

Cancer Cell(2017)10.1016/j.ccell.2016.11.017Source: DataRank Database

FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N 6 -Methyladenosine RNA Demethylase is a research paper published in Cancer Cell (2017). On theSindex it has a DataRank of 15.7. It has been cited 1,638 times, with 200 citing works in its 1-hop citation network.

N/A

15.7DataRank · unranked

Scored on demand from live citation data

1,638 citations · 200 citing works in its network

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (24 grants)Impact (FWCI 41.23)OA: closedTopics (70)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (0/2)

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 7%Citation Network 93%

Base Score Contribution

1.1

From this paper's citation signal

Citation Network Contribution

14.6

From 200 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 200 citers.

Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia
Journal of Hematology & Oncology2017208 citations10 referencesContributes 0.534
The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA
Biochemical and Biophysical Research Communications2019243 citations23 referencesContributes 0.239
An Elongation‐ and Ligation‐Based qPCR Amplification Method for the Radiolabeling‐Free Detection of Locus‐Specific N6‐Methyladenosine Modification
Angewandte Chemie International Edition2018365 citations27 referencesContributes 0.219
The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
Nature Medicine20171,328 citations39 referencesContributes 0.184
RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2
Hepatology20171,546 citations41 referencesContributes 0.179

Authors (29)

Hengyou Weng ORCID,Rui Su ORCID,Xiaocheng Weng ORCID,Zhixiang Zuo ORCID,Chenying Li

Live enrichment

PubMed:28017614 PMC:PMC5234852 OpenAlex:https://openalex.org/W2563912688

NIH

Grant: CA178454

NIH

Grant: CA182528

NIH

Grant: CA214965

NIH

Grant: GM071440

Foundation of Innovation Team for Basic and Clinical Research of Zhejiang Province

Grant: 2011R50015

NCI NIH HHS

Grant: R01 CA214965

NCI NIH HHS

Grant: R01 CA122623

NCI NIH HHS

Grant: R01 CA182528

NCI NIH HHS

Grant: T32 CA009594

NCI NIH HHS

Grant: R01 CA178454

NCI NIH HHS

Grant: R01 CA211614

NCI NIH HHS

Grant: R01 CA116097

NIGMS NIH HHS

Grant: R01 GM071440

National Institutes of Health

Grant: 1R01CA214965-01

The role and mechanism of FTO in leukemogenesis and drug response

National Institutes of Health

Grant: 5R01CA182528-05

Potential therapeutic implications of targeting miR-150 in acute myeloid leukemia

National Institutes of Health

Grant: 7R01CA178454-06

The role and functional mechanism of TET1 in MLL-rearranged leukemia

Howard Hughes Medical Institute

Gabrielle's Angel Foundation for Cancer Research

China Scholarship Council

Leukemia & Lymphoma Society

ACS-IL Research Scholar

LLS Translational Research

American Cancer Society

Howard Hughes Medical Institute

FWCI

41.23

Citation Percentile

1.0%

Citation Trend

2017

2018

2019

2020

2021

2022

2023

2024

2025

2026

closedLicense: Elsevier Non-Commercial

publisherhttps://api.elsevier.com/content/article/PII:S1535610816305608?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1535610816305608?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.ccell.2016.11.017

repositoryhttps://pubmed.ncbi.nlm.nih.gov/28017614

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/5234852

Fields of Study

RNA modifications and cancerCancer-related gene regulationEpigenetics and DNA Methylation0301 basic medicine0303 health sciences03 medical and health sciencesAdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOApoptosisCell ProliferationHumansLeukemia, Myeloid, AcuteMethylationNucleophosminRetinoic Acid Receptor alphaSuppressor of Cytokine Signaling ProteinsTranscriptomeTretinoin

MeSH Terms

Alpha-Ketoglutarate-Dependent Dioxygenase FTORetinoic Acid Receptor alphaNucleophosminAdenosineHumansMethylationTretinoinLeukemia, Myeloid, AcuteApoptosisCell ProliferationSuppressor of Cytokine Signaling ProteinsTranscriptome

Keywords

DemethylaseMyeloid leukemiaN6-MethyladenosineBiologyCancer researchRNA methylationMyeloidOncogeneLeukemiaRetinoic acidRNACellMethylationCell biologyEpigeneticsCell cycleGeneGeneticsMethyltransferaseCell differentiationAMlATRALeukemogenesisRna StabilityRaraFtoRna ModificationM6aAsb2AdenosineRetinoic Acid Receptor alphaAlpha-Ketoglutarate-Dependent Dioxygenase FTOApoptosisSuppressor of Cytokine Signaling ProteinsTretinoinLeukemia, Myeloid, AcuteHumansTranscriptomeNucleophosminCell Proliferation

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being