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Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Cancer Cell(2020)10.1016/j.ccell.2020.04.017Source: DataRank Database

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion is a research paper published in Cancer Cell (2020). On theSindex it has a DataRank of 8.5. It has been cited 777 times, with 200 citing works in its 1-hop citation network.

N/A

8.5DataRank · unranked

Scored on demand from live citation data

Open Access777 citations · 200 citing works in its network

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Linked data & code

geo gen cellosaurus pdb doi

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (24 grants)Impact (FWCI 32.50)OA: bronzeTopics (40)IDs (PubMed, PMC, OpenAlex)Annotations (5)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 12%Citation Network 88%

Base Score Contribution

0.999

From this paper's citation signal

Citation Network Contribution

7.5

From 200 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 200 citers.

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Authors (39)

Lei Dong ORCID,Yangchan Li ORCID,Min Gao ORCID,Li Han ORCID,Mark Wunderlich ORCID

Live enrichment

PubMed:32531268 PMC:PMC7363590 OpenAlex:https://openalex.org/W3034923646

National Institutes of Health

Grant: P30CA33572

National Institutes of Health

Grant: R01 CA211614

National Institutes of Health

Grant: R01 CA214965

National Institutes of Health

Grant: R01 CA236399

National Institutes of Health

Grant: R01 CA243386

National Institutes of Health

Grant: R01 DK124116

American Cancer Society

Grant: R01CA137060

American Cancer Society

Grant: R01CA157644

American Cancer Society

Grant: R01CA172558

American Cancer Society

Grant: R01CA213138

American Cancer Society

Grant: R35CA197628

American Cancer Society

Grant: R50CA211404

American Cancer Society

Grant: U10CA180827

NCI NIH HHS

Grant: T32 CA186895

NCI NIH HHS

Grant: R01 CA169458

NCI NIH HHS

Grant: P30 CA033572

Astellas Pharma US

Chinese Academy of Sciences

Leukemia and Lymphoma Society

AbbVie

Daiichi-Sankyo

Howard Hughes Medical Institute

National Cancer Institute

Shanghai Institute of Materia Medica, Chinese Academy of Sciences

FWCI

32.50

Citation Percentile

1.0%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

bronzeLicense: http://www.elsevier.com/open-access/userlicense/1.0/

journalhttp://www.cell.com/article/S1535610820302166/pdf

publisherhttp://www.cell.com/article/S1535610820302166/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1535610820302166?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1535610820302166?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.ccell.2020.04.017

Fields of Study

RNA modifications and cancerImmune Cell Function and InteractionRNA Research and Splicing

MeSH Terms

Cell Self RenewalAlpha-Ketoglutarate-Dependent Dioxygenase FTOProtein DomainsAnthracenesBiphenyl CompoundsCell SurvivalEnzyme InhibitorsHumansLeukemiaMembrane GlycoproteinsProtein BindingQuinaldinesReceptors, ImmunologicMolecular StructureGene Expression Regulation, NeoplasticU937 CellsCell Line, TumorImmune Evasion

Keywords

Evasion (ethics)Immune systemCancer researchCancerBiologyStem cellImmunologyCell biologyGeneticsLeukemiaInhibitorsTherapeuticsSolid TumorsImmune EvasionFtoLilrb4Immune Checkpoint GenesN(6)-methyladenosine (M(6)a) ModificationLsc/lic Self-renewal

Sustainable Development Goals

SDG 0: Good health and well-being