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FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma

Cancer Cell(2025)10.1016/j.ccell.2025.02.001Source: DataRank Database

FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma is a research paper published in Cancer Cell (2025). On theSindex it has a DataRank of 0. It has been cited 38 times.

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Enrichment:Funding (22 grants)OA: greenTopics (40)IDs (PubMed, PMC)Annotations (2)

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Authors (20)

Rodolfo Daniel Cervantes‐Villagrana ORCID,Farhoud Faraji ORCID,Sydney I. Ramirez ORCID,Kuniaki Sato ORCID,Sendi Rafael Adame-Garcia ORCID

Live enrichment

PubMed:40020669 PMC:PMC11903146

European Commission Marie Sklodowska-Curie Actions

Grant: 101027731

National Institutes of Health National Cancer Institute

Grant: CA257505

National Institutes of Health National Cancer Institute

Grant: 5U54CA209891

Huntsman Cancer Foundation

Grant: R01s CA182635

National Science Foundation Division of Graduate Education

Grant: MRA827624

American Head and Neck Society

Grant: DGE - 1650112

American Head and Neck Society

Grant: T32GM007752

American Head and Neck Society

Grant: 1061310

National Institute on Deafness and Other Communication Disorders

Grant: T32DC000028

NCI NIH HHS

Grant: R01 CA121118

NCI NIH HHS

Grant: R01 CA257505

NLM NIH HHS

Grant: T15 LM011271

NCI NIH HHS

Grant: R01 CA182635

NCI NIH HHS

Grant: U54 CA209891

NIGMS NIH HHS

Grant: P41 GM103504

Horizon 2020 Framework Programme

Melanoma Research Alliance

NIH National Institute of General Medical Sciences

H2020 Marie Skłodowska-Curie Actions

Horizon 2020

Ministero dell’Istruzione, dell’Università e della Ricerca

National Institutes of Health

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11903146/

publisherhttps://api.elsevier.com/content/article/PII:S1535610825000534?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1535610825000534?httpAccept=text/plain

Fields of Study

MelanomaHumansAnimalsProto-Oncogene Proteins B-rafDrug Resistance, NeoplasmMiceCell Line, TumorProtein Kinase InhibitorsImmunotherapyFocal Adhesion Kinase 1MutationApoptosisMAP Kinase Signaling SystemXenograft Model Antitumor AssaysAntineoplastic Combined Chemotherapy Protocols

MeSH Terms

Cell Line, TumorAnimalsHumansMiceMelanomaProto-Oncogene Proteins B-rafAntineoplastic Combined Chemotherapy ProtocolsProtein Kinase InhibitorsImmunotherapyXenograft Model Antitumor AssaysApoptosisMAP Kinase Signaling SystemDrug Resistance, NeoplasmMutationFocal Adhesion Kinase 1

Keywords

ResistanceMelanomaSignal transductionImmunotherapyFAKMEKMAPK signalingBrafTargeted TherapiesAvutometinib

FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma

FAIR Checklist

Authors (20)

Funding (22 grants)

Open Access

Topics

Annotations (Europe PMC)