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Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits

Cell(2025)10.1016/j.cell.2025.02.012Source: DataRank Database

Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits is a research paper published in Cell (2025). On theSindex it has a DataRank of 0. It has been cited 93 times.

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Open Access93 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (6 grants)Impact (FWCI 39.27)OA: hybridTopics (32)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Aiping Jiang ORCID,Serwah Danquah,Vera Valakh ORCID,Brooke Simonton ORCID,Jon Bezney ORCID

Live enrichment

PubMed:40081369 PMC:PMC12135205 OpenAlex:https://openalex.org/W4408363679

Simons Foundation

Grant: 890477

NIMH NIH HHS

Grant: R01 MH128366

NIMH NIH HHS

Grant: RF1 MH121289

National Institutes of Health

Israel Science Foundation

National Institute of Mental Health and Neurosciences

FWCI

39.27

Citation Percentile

1.0%

Citation Trend

2025

2026

hybridLicense: cc-by

journalhttps://portals.broadinstitute.org/gpp/public/dir/download?dirpath=protocols/production&filename=TRC%20shRNA%20sgRNA%20ORF%20Low%20Throughput%20Viral%20Production%20201506.pdf

publisherhttps://portals.broadinstitute.org/gpp/public/dir/download?dirpath=protocols/production&filename=TRC%20shRNA%20sgRNA%20ORF%20Low%20Throughput%20Viral%20Production%20201506.pdf

publisherhttps://api.elsevier.com/content/article/PII:S0092867425001977?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0092867425001977?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.cell.2025.02.012

Fields of Study

Single-cell and spatial transcriptomicsCRISPR and Genetic EngineeringCell Image Analysis Techniques

MeSH Terms

Autism Spectrum DisorderAnimalsAstrocytesHumansImmunity, InnateLipopolysaccharidesMonocytesGene Expression ProfilingMiceGene Regulatory NetworksInduced Pluripotent Stem CellsSingle-Cell AnalysisTranscriptomeClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas Systems

Keywords

BiologyCRISPRIntracellularTranscriptomeComputational biologyCell biologyGeneticsGene expressionGeneMultimodal ScreeningPooled Crispr ScreenSpatial TranscriptomicsPooled Optical ProfilingSingle-cell Perturbations