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DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding

Cell Reports(2022)10.1016/j.celrep.2022.110369Source: DataRank Database

DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding is a research paper published in Cell Reports (2022). On theSindex it has a DataRank of 0. It has been cited 24 times.

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Open Access24 citations

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refseq pdb

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (15 grants)Impact (FWCI 1.73)OA: goldTopics (69)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Satya P. Yadav ORCID,Dongxu Li ORCID,Carinne N. Geil ORCID,C. B. Smith ORCID,Gang Greg Wang ORCID

Live enrichment

PubMed:35172132 PMC:PMC8919193 OpenAlex:https://openalex.org/W4213038020

National Institutes of Health

Grant: R01CA211336

National Institutes of Health

Grant: R35GM133498

National Institutes of Health

Grant: F99CA253730

National Institutes of Health

Grant: R01GM130793

National Institutes of Health

Grant: R01GM123164

National Institutes of Health

Grant: R01CA215284

University of North Carolina

Grant: P30CA016086

NIGMS NIH HHS

Grant: R35 GM148208

National Institutes of Health

Grant: 5R01CA215284-04

Determining the Role of DNA Methylation Deregulation in Oncogenesis

National Institutes of Health

Grant: 5R01GM130793-02

Effects of histone ubiquitylation on nucleosome dynamics

National Institutes of Health

Grant: 1F99CA253730-01

Structure-Guided Mechanistic Studies of Dot1L in Mixed Lineage Leukemia

National Institutes of Health

Grant: 5R35GM133498-04

Molecular Mechanisms of Chromatin Recognition

National Institutes of Health

Grant: 5R01CA211336-05

Cancer Epigenetics: A novel PRC2 Dysregulation Mechanism in Multiple Myeloma

National Institutes of Health

Grant: 3P30CA016086-42S2

Cancer Center Support Grant

National Institutes of Health

Grant: 5R01GM123164-04

Dynamics of histone-DNA interaction

FWCI

1.73

Citation Percentile

0.8%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttp://www.cell.com/article/S2211124722000900/pdf

publisherhttp://www.cell.com/article/S2211124722000900/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2211124722000900?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124722000900?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.celrep.2022.110369

Fields of Study

CRISPR and Genetic EngineeringGenomics and Chromatin DynamicsRNA modifications and cancer0301 basic medicine0303 health sciences03 medical and health sciencesCell Line, TumorCell ProliferationGene RearrangementHistone-Lysine N-MethyltransferaseHistonesHumansLeukemiaLysineMaleMethylationModels, MolecularMyeloid-Lymphoid Leukemia ProteinNucleosomesProtein BindingUbiquitinUbiquitination

MeSH Terms

HistonesHumansLeukemiaLysineMaleMethylationModels, MolecularNucleosomesProtein BindingHistone-Lysine N-MethyltransferaseGene RearrangementUbiquitinCell Line, TumorCell ProliferationMyeloid-Lymphoid Leukemia ProteinUbiquitination

Keywords

NucleosomeCell biologyLeukemiaChemistryBiologyBiochemistryChromatinGeneticsDNAHistoneLysine MethyltransferaseDot1lSingle-molecule FretMll-rearranged LeukemiaMixed Lineage Leukemia (Mll)Gene RearrangementMaleModels, MolecularUbiquitinLysineUbiquitinationHistone-Lysine N-MethyltransferaseMethylationArticleNucleosomesHistonesCell Line, TumorHumansMyeloid-Lymphoid Leukemia ProteinCell ProliferationProtein Binding

Sustainable Development Goals

SDG 3: 3. Good health