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Human antibody polyreactivity is governed primarily by the heavy-chain complementarity-determining regions

Cell Reports(2024)10.1016/j.celrep.2024.114801Source: DataRank Database

Human antibody polyreactivity is governed primarily by the heavy-chain complementarity-determining regions is a research paper published in Cell Reports (2024). On theSindex it has a DataRank of 0. It has been cited 15 times.

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Open Access15 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (11 grants)Impact (FWCI 3.97)OA: goldTopics (37)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (13)

Yulei Zhang ORCID,Jie Huang ORCID,Manali Sawant ORCID,Matthew D. Smith ORCID,Nandhini Rajagopal ORCID

Live enrichment

PubMed:39392756 PMC:PMC11564698 OpenAlex:https://openalex.org/W4403292899

National Science Foundation

Grant: DGE 1256260

National Institutes of Health

Grant: R35GM136300

National Institutes of Health

Grant: RF1AG059723

National Institutes of Health

Grant: R21AI171844

National Institutes of Health

Grant: R01AG080016

National Science Foundation

Grant: 1256260

Graduate Research Fellowship Program (GRFP)

National Institutes of Health

Grant: 5R01AG080016-02

CD98hc Brain Shuttles for Delivering Off-the-shelf Neuroprotective Antibodies in Alzheimer's Disease

National Institutes of Health

Grant: 5R35GM136300-04

Structure-guided antibody targeting of pre-selected epitopes in amyloidogenic aggregates

National Institutes of Health

Grant: 3RF1AG059723-01S1

Design and Evolution of Polyvalent Domain Antibodies Specific for Tau Aggregates

National Institutes of Health

Grant: 5R21AI171844-02

Mutational Analysis of Tradeoffs between Receptor Affinity and Antibody Escape for SARS-CoV-2 Variants of Concern

Boehringer Ingelheim

FWCI

3.97

Citation Percentile

0.9%

Citation Trend

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.celrep.2024.114801

publisherhttps://doi.org/10.1016/j.celrep.2024.114801

publisherhttps://api.elsevier.com/content/article/PII:S2211124724011525?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124724011525?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39392756

Fields of Study

Monoclonal and Polyclonal Antibodies ResearchProtein purification and stabilityHER2/EGFR in Cancer Research03 medical and health sciences0302 clinical medicine

MeSH Terms

Amino Acid SequenceAntibodiesAntibody SpecificityHumansImmunoglobulin Heavy ChainsComplementarity Determining Regions

Keywords

Complementarity (molecular biology)Heavy chainAntibodyComputational biologyPhysicsBiologyChemistryGeneticsAntibody engineeringPharmacokineticMachine LearningDeep SequencingNonspecificityRepertoireNon-specific BindingDevelopabilityPolyspecificityOff-target BindingCp: ImmunologyAntibody SpecificityHumansAmino Acid SequenceImmunoglobulin Heavy ChainsComplementarity Determining RegionsArticleAntibodies

Sustainable Development Goals

SDG 0: Zero hunger