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Rationally designed pooled CRISPRi-seq uncovers an inhibitor of bacterial peptidyl-tRNA hydrolase

Cell Reports(2024)10.1016/j.celrep.2024.114967Source: DataRank Database

Rationally designed pooled CRISPRi-seq uncovers an inhibitor of bacterial peptidyl-tRNA hydrolase is a research paper published in Cell Reports (2024). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Enrichment:Funding (9 grants)OA: goldTopics (45)IDs (PubMed)

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Authors (6)

Egor A. Syroegin ORCID,Julieta Novomisky Nechcoff ORCID,Archit Devarajan ORCID,Yury S. Polikanov ORCID,Silvia T. Cardona ORCID

Live enrichment

PubMed:39541213

National Institutes of Health

Grant: R21-AI163466

National Institutes of Health

Grant: R01-GM132302

Canadian Institutes of Health Research

Grant: 169121

Cystic Fibrosis Canada

Grant: 609522

Cystic Fibrosis Foundation

Grant: CARDON18I0

National Science Foundation

Grant: MCB-1907273

Canadian Institutes of Health Research

Grant: unidentified

unidentified

NIGMS NIH HHS

Grant: R01 GM132302

NIAID NIH HHS

Grant: R21 AI163466

goldLicense: cc-by-nc

publisherhttps://www.cell.com/cell-reports/pdf/S2211-1247(24)01318-4.pdf

publisherhttps://api.elsevier.com/content/article/PII:S2211124724013184?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124724013184?httpAccept=text/plain

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12399363/pdf/nihms-2105962.pdf

repositoryhttps://doaj.org/article/dec81f5c2a76421fa935bd0875c98e1e

Fields of Study

0301 basic medicine03 medical and health sciencesCarboxylic Ester HydrolasesBurkholderia cenocepaciaAnti-Bacterial AgentsCRISPR-Cas SystemsClustered Regularly Interspaced Short Palindromic RepeatsGene LibraryBacterial ProteinsEnzyme InhibitorsGenes, EssentialMutation

MeSH Terms

Carboxylic Ester HydrolasesBurkholderia cenocepaciaAnti-Bacterial AgentsCRISPR-Cas SystemsClustered Regularly Interspaced Short Palindromic RepeatsGene LibraryBacterial ProteinsEnzyme InhibitorsGenes, EssentialMutation

Keywords

Genes, EssentialQH301-705.5Burkholderia cenocepaciaCP: MicrobiologyArticleAnti-Bacterial AgentsBacterial ProteinsMutationClustered Regularly Interspaced Short Palindromic RepeatsBiology (General)CRISPR-Cas SystemsEnzyme InhibitorsCarboxylic Ester HydrolasesGene LibraryCRISPRiCRISPRi-seqPthantibiotic mechanisms of actionarrayed libraryessential genespeptidyl-tRNA hydrolasepooled libraryribosome-associated quality control