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A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader

Cell chemical biology(2022)10.1016/j.chembiol.2022.05.003Source: DataRank Database

A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader is a research paper published in Cell chemical biology (2022). On theSindex it has a DataRank of 0. It has been cited 40 times.

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Open Access40 citations

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cellosaurus

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Enrichment:Funding (6 grants)Impact (FWCI 3.06)OA: bronzeTopics (55)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Semer Maksoud ORCID,Bakhos A. Tannous ORCID,Ralph Mazitschek ORCID,N. Connor Payne ORCID

Live enrichment

PubMed:35649410 PMC:PMC9391279 OpenAlex:https://openalex.org/W4281661759

NIH

Grant: 1R01NS064983

National Science Foundation

Grant: DGE1745303

National Science Foundation

Grant: 1830941

EFRI CEE: Human cardiac opto-epigenetics with HDAC inhibitors

NINDS NIH HHS

Grant: R01 NS064983

National Science Foundation

Grant: 1745303

Graduate Research Fellowship Program (GRFP)

National Institutes of Health

Grant: 5R01NS064983-08

Glioblastoma stem cells therapy

FWCI

3.06

Citation Percentile

0.9%

Citation Trend

2022

2023

2024

2025

2026

bronzeLicense: Elsevier Non-Commercial

journalhttp://www.cell.com/article/S2451945622001659/pdf

publisherhttp://www.cell.com/article/S2451945622001659/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2451945622001659?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2451945622001659?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.chembiol.2022.05.003

Fields of Study

Protein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments0301 basic medicine0303 health sciences03 medical and health sciencesCell Cycle ProteinsHumansNuclear ProteinsPentacyclic TriterpenesProteolysisTranscription FactorsUbiquitin-Protein LigasesBromodomain Containing Proteins

MeSH Terms

Bromodomain Containing ProteinsHumansNuclear ProteinsTranscription FactorsCell Cycle ProteinsUbiquitin-Protein LigasesPentacyclic TriterpenesProteolysis

Keywords

CelastrolThroughputBRD4Characterization (materials science)Computer scienceComputational biologyChemistryBiologyNanotechnologyBromodomainMaterials scienceHistoneDNABiochemistryApoptosisTelecommunicationsSmall moleculesHigh-throughputReversibleProtein QuantificationCovalentTr-fretProtacTargeted Protein DegradationDegraderBromodomain Containing ProteinsUbiquitin-Protein LigasesProteolysisHumansNuclear ProteinsCell Cycle ProteinsPentacyclic TriterpenesTranscription Factors

Sustainable Development Goals

SDG 0: Affordable and clean energy