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The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr

Cell Host & Microbe(2021)10.1016/j.chom.2021.03.001Source: DataRank Database

The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr is a research paper published in Cell Host & Microbe (2021). On theSindex it has a DataRank of 0.673. It has been cited 88 times.

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0.673DataRank · unranked

Scored on demand from live citation data

Open Access88 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (15 grants)Impact (FWCI 8.93)OA: hybridTopics (61)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.673

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

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Authors (11)

Stuart Bloor ORCID,James C. Williamson ORCID,Sergio Martinez Cuesta ORCID,Raven Shah ORCID,Ana Teixeira-Silva ORCID

Live enrichment

PubMed:33811831 PMC:PMC8118623 OpenAlex:https://openalex.org/W3144428025

National Institutes of Health

Grant: U54 AI150472

National Institutes of Health

Grant: R01 AI120860

National Institutes of Health

Grant: R01 AI146017

National Institutes of Health

Grant: 209441/z/17/z

Wellcome Trust

Grant: 210688/Z/18/Z

Wellcome Trust

Grant: 109074/Z/15/Z

NIHR Cambridge Biomedical Research Centre

Grant: NL4-3

Medical Research Council

Grant: MR/P008801/1

National Institutes of Health

Grant: 5R01AI146017-02

Novel mechanism of integrase (IN) resistance to Dolutegravir through epistatic interactions between IN and the nucleocapsid and polypurine tract regions of HIV-1

Wellcome Trust

Grant: 210688

Viral silencing and immune evasion pathways

Wellcome Trust

Grant: 109074

Cambridge, Infection, Immunity and Inflammation.

Wellcome Trust

Grant: 209441

The chemical biology and function of natural modified DNA bases in genomes

National Institutes of Health

Grant: 7U54AI150472-10

HIV Interactions In Viral Evolution

National Institutes of Health

Grant: 5R01AI120860-09

Development of HIV capsid-targeting antivirals that affect immune response by modulating capsid stability and have improved resistance profiles

University of Cambridge

FWCI

8.93

Citation Percentile

1.0%

Influential Citations

Citation Trend

2020

2021

2022

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2025

2026

hybridLicense: cc-by

journalhttp://www.cell.com/article/S1931312821001013/pdf

HYBRIDhttp://www.cell.com/article/S1931312821001013/pdf

publisherhttp://www.cell.com/article/S1931312821001013/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1931312821001013?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1931312821001013?httpAccept=text/plain

Fields of Study

HIV Research and Treatmentinterferon and immune responsesRNA Research and SplicingMedicineBiology0301 basic medicine0303 health sciences03 medical and health sciencesCell Cycle ProteinsChromosomal Proteins, Non-HistoneHIV InfectionsHIV-1Host-Pathogen InteractionsHumansUbiquitin-Protein LigasesVirus IntegrationVirus Replicationvpr Gene Products, Human Immunodeficiency VirusReceptors, Interleukin-17

MeSH Terms

Chromosomal Proteins, Non-HistoneHumansVirus ReplicationHIV-1HIV InfectionsVirus IntegrationCell Cycle ProteinsUbiquitin-Protein LigasesReceptors, Interleukin-17vpr Gene Products, Human Immunodeficiency VirusHost-Pathogen Interactions

Keywords

BiologyChromatinCell biologyGene silencingInnate immune systemVirologyDNAGeneticsGeneImmune systemHIV-1VprChromatin CompactionAtac-seqExtrachromosomal DnaSmc5-smc6 ComplexCrispr-cas9 Knockout ScreenSlf2Unintegrated LentivirusViral Gene SilencingReceptors, Interleukin-17Chromosomal Proteins, Non-HistoneUbiquitin-Protein LigasesVirus IntegrationCell Cycle ProteinsHIV Infectionsvpr Gene Products, Human Immunodeficiency VirusVirus ReplicationArticleHost-Pathogen InteractionsHumans

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being