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Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27

Current Biology(2024)10.1016/j.cub.2024.10.061Source: DataRank Database

Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27 is a research paper published in Current Biology (2024). On theSindex it has a DataRank of 0.535. It has been cited 16 times, with 16 citing works in its 1-hop citation network.

N/A

0.535DataRank · unranked

Scored on demand from live citation data

Open Access16 citations · 16 citing works in its network

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Linked data & code

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 4.42)OA: greenTopics (34)IDs (PubMed, PMC, OpenAlex)Annotations (4)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 79%Citation Network 21%

Base Score Contribution

0.425

From this paper's citation signal

Citation Network Contribution

0.110

From 5 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 16 citers.

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Cell Discovery20265 citations31 referencesContributes 0.058
Post-translational modifications in heat stress-related diseases
Frontiers in Molecular Biosciences20256 citations84 referencesContributes 0.023
Lysosomal membrane homeostasis and its importance in physiology and disease
Nature Reviews Molecular Cell Biology202548 citations197 referencesContributes 0.020
Enantioselective Modulation of Inflammatory Response through MAPK Pathway by Wavelike Chiral Nanoparticles
Environment & Health20251 citations36 referencesContributes 0.019
PEX5 integrates the p38 MAPK signaling pathway and taurine metabolism to regulate senescence in lung fibroblasts
Experimental Cell Research20261 citations71 referencesContributes 0.010

Authors (6)

Peace T. Oloko,Tessa C. Fitch ORCID,Elizabeth M. Brown,Lynn A. Spruce ORCID,Erika L.F. Holzbaur ORCID

Live enrichment

PubMed:39541976 PMC:PMC11652224 OpenAlex:https://openalex.org/W4404320823

National Institute of General Medical Sciences

Grant: T32 GM007229

National Institute of Neurological Disorders and Stroke

Grant: F31 NS125954

National Institute of Neurological Disorders and Stroke

Grant: R01 NS060698

National Institutes of Health

FWCI

4.42

Citation Percentile

1.0%

Citation Trend

2025

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11652224/pdf/nihms-2035268.pdf

publisherhttps://api.elsevier.com/content/article/PII:S096098222401457X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S096098222401457X?httpAccept=text/plain

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11652224/

Fields of Study

Autophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseHeat shock proteins research

MeSH Terms

Sequestosome-1 ProteinMAP-Kinase-Activated Kinase 2AutophagyHeat-Shock ProteinsHumansLysosomesPhosphorylationSignal TransductionProtein Serine-Threonine KinasesMolecular ChaperonesIntracellular Signaling Peptides and Proteinsp38 Mitogen-Activated Protein KinasesHSP27 Heat-Shock Proteins

Keywords

BiologyHsp27Heat shock proteinPhosphorylationp38 mitogen-activated protein kinasesCell biologyCascadeShock (circulatory)MAPK/ERK pathwayHsp70BiochemistryInternal medicineGenePhase separationp38 MAPKOligomersSqstm1/p62Lysophagy

Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (6)

Funding (4 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)