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High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1

Heart Rhythm(2020)10.1016/j.hrthm.2020.05.041Source: DataRank Database

High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1 is a research paper published in Heart Rhythm (2020). On theSindex it has a DataRank of 1.8. It has been cited 66 times, with 44 citing works in its 1-hop citation network.

N/A

1.8DataRank · unranked

Scored on demand from live citation data

Open Access66 citations · 44 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (12 grants)Impact (FWCI 5.54)OA: greenTopics (39)Linked Datasets (18)DataCite Reuse (18)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 35%Citation Network 65%

Base Score Contribution

0.631

From this paper's citation signal

Citation Network Contribution

1.2

From 37 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 44 citers.

Automated patch clamp in drug discovery: major breakthroughs and innovation in the last decade
Expert Opinion on Drug Discovery202073 citations28 referencesContributes 0.154
A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer
Wellcome Open Research202013 citations28 referencesContributes 0.094
Loss‐of‐function variants in Kv11.1 cardiac channels as a biomarker for SUDEP
Annals of Clinical and Translational Neurology202118 citations34 referencesContributes 0.087
A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer
Wellcome Open Research202117 citations35 referencesContributes 0.083
Molecular and cellular context influences SCN8A variant function
JCI Insight202424 citations48 referencesContributes 0.067

Authors (14)

Andrew M. Glazer ORCID,Chai‐Ann Ng ORCID,Daniel J. Blackwell ORCID,Christian Egly,Loren Vanags

Live enrichment

PubMed:32522694 OpenAlex:https://openalex.org/W3033147615

Vanderbilt-Ingram Cancer Center

Grant: P30 CA68485

Fondation Leducq

Grant: 18CVD05

National Institutes of Health

Grant: 1R01GM109110

National Institutes of Health

Grant: F32HL137385

National Institutes of Health

Grant: R00HL135442

NCRR NIH HHS

Grant: UL1 RR024975

NIGMS NIH HHS

Grant: R01 GM109110

NHGRI NIH HHS

Grant: K99 HG010904

NHLBI NIH HHS

Grant: R35 HL144980

NIH HHS

Grant: S10 OD025281

NHLBI NIH HHS

Grant: R01 HL149826

NCI NIH HHS

Grant: P30 CA068485

FWCI

5.54

Citation Percentile

1.0%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

greenLicense: https://www.elsevier.com/legal/tdmrep-license

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7704534

publisherhttps://api.elsevier.com/content/article/PII:S1547527120305427?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1547527120305427?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.hrthm.2020.05.041

Fields of Study

Cardiac electrophysiology and arrhythmiasIon channel regulation and functionReceptor Mechanisms and SignalingCell LineDNADNA Mutational AnalysisERG1 Potassium ChannelHumansLong QT SyndromeMutationMyocardiumPatch-Clamp Techniques

MeSH Terms

ERG1 Potassium ChannelCell LineDNADNA Mutational AnalysisHumansLong QT SyndromeMutationMyocardiumPatch-Clamp Techniques

Keywords

Missense mutationPotassium channelhERGLong QT syndromeHEK 293 cellsMedicineCell biologyMutationBiologyBiophysicsGeneticsInternal medicineGeneQT intervalDeep mutational scanningK(V)11.1KCNH2Membrane trafficking

Sustainable Development Goals

SDG 0: Peace, Justice and strong institutions

Additional file 9 of High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

10.6084/m9.figshare.26727448.v1figshare

Additional file 9 of High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

10.6084/m9.figshare.26727448figshare

Additional file 7 of High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

10.6084/m9.figshare.26727442.v1figshare

Additional file 8 of High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

10.6084/m9.figshare.26727445.v1figshare

Additional file 8 of High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

10.6084/m9.figshare.26727445figshare

Additional file 4 of High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

10.6084/m9.figshare.26727433figshare

Additional file 6 of High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

10.6084/m9.figshare.26727439figshare

Additional file 7 of High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

10.6084/m9.figshare.26727442figshare

Additional file 4 of High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

10.6084/m9.figshare.26727433.v1figshare

Additional file 6 of High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

10.6084/m9.figshare.26727439.v1figshare

Additional file 5 of High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

10.6084/m9.figshare.26727436figshare

Additional file 5 of High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

10.6084/m9.figshare.26727436.v1figshare

Additional file 2 of High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

10.6084/m9.figshare.25940194figshare

Additional file 1 of High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

10.6084/m9.figshare.25940061figshare

Additional file 1 of High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

10.6084/m9.figshare.25940061.v1figshare

Additional file 3 of High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

10.6084/m9.figshare.26727430.v1figshare

Additional file 2 of High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

10.6084/m9.figshare.25940194.v1figshare

Additional file 3 of High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

10.6084/m9.figshare.26727430figshare

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