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Structural and functional characterization of G protein–coupled receptors with deep mutational scanning

eLife(2020)10.7554/elife.54895Source: DataRank Database

Structural and functional characterization of G protein–coupled receptors with deep mutational scanning is a research paper published in eLife (2020). On theSindex it has a DataRank of 3.9. It has been cited 176 times, with 100 citing works in its 1-hop citation network.

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3.9DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access176 citations · 100 citing works in its network

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Linked data & code

geo gen pdb

Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE144819

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (14 grants)OA: goldTopics (61)IDs (PubMed, PMC)Annotations (3)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 20%Citation Network 80%

Base Score Contribution

0.776

From this paper's citation signal

Citation Network Contribution

3.1

From 100 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 100 citers.

GPCRdb in 2021: integrating GPCR sequence, structure and function
Nucleic Acids Research2020378 citations42 referencesContributes 0.141
Commentary on “Novel Interaction of the Dopamine D2 Receptor and the Ca2+ Binding Protein S100B: Role in D2 Receptor Function”
Molecular Pharmacology20213 citations10 referencesContributes 0.139
Computationally-guided tuning of ligand sensitivity in a GPCR-based sensor
bioRxiv (Cold Spring Harbor Laboratory)20213 citations11 referencesContributes 0.126
A map of the rubisco biochemical landscape
Nature202565 citations42 referencesContributes 0.100
Predicting the pathogenicity of missense variants using features derived from AlphaFold2
Bioinformatics202371 citations44 referencesContributes 0.097

Authors (13)

Nathan B. Lubock ORCID,AJ Venkatakrishnan ORCID,Jeffrey Wang,Alex M. Tseng ORCID,Joseph M. Paggi ORCID

Live enrichment

PubMed:33084570 PMC:PMC7707821

National Science Foundation

Grant: 1556207

Collaborative Research: Analysis of the Mammalian Olfactory Code

National Institutes of Health

Grant: GM007185

National Institutes of Health

Grant: 5T32GM008496

National Institutes of Health

Grant: DP2GM114829

Medical Research Council

Grant: MC_U105185859

Regulatory Genomics and System Biology

National Institutes of Health

Grant: GM127359

NIGMS NIH HHS

Grant: T32 GM008496

NIGMS NIH HHS

Grant: R01 GM127359

NIGMS NIH HHS

Grant: T32 GM007185

National Institutes of Health

Grant: 5T32GM008496-19

Chemistry Biology Interface Training Program

National Institutes of Health

Grant: 5R01GM127359-03

Discovering the mechanism of GPCR-mediated arrestin stimulation to enable effective drug therapies

National Health and Medical Research Council (NHMRC)

Grant: 1051858

Autocrine Vitamin D Metabolism, Activity and Bone Health

National Institutes of Health

Grant: 5T32GM007185-39

Research Training in Cellular and Molecular Biology

National Institutes of Health

Grant: 1DP2GM114829-01

REVERSE GENOMICS OF REGULATORY ELEMENTS GOVERNING SPLICING

goldLicense: cc-by

publisherhttps://doi.org/10.7554/elife.54895

publisherhttps://cdn.elifesciences.org/articles/54895/elife-54895-v2.pdf

publisherhttps://cdn.elifesciences.org/articles/54895/elife-54895-v2.xml

publisherhttps://elifesciences.org/articles/54895

repositoryhttps://doaj.org/article/eef860197db949eb8e173ad8316b333e

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

HumansReceptors, G-Protein-CoupledCloning, MolecularDNA Mutational AnalysisProtein ConformationModels, MolecularHEK293 CellsDNA Barcoding, TaxonomicMachine LearningGene Editing

Keywords

HumanBiochemistryG proteinFunctional genomicsCell signalingReporter AssaysChemical BiologyMassively ParallelDeep Mutational ScanningStructure FunctionCoupled ReceptorsModels, MolecularBiomedical and clinical sciencesProtein ConformationDNA Mutational AnalysisReceptors, G-Protein-CoupledMachine LearningModelsReceptors2.1 Biological and endogenous factorsAetiologyBiology (General)Cloning, MolecularGene EditingQRPharmacology and Pharmaceutical SciencesBiological SciencesDNA BarcodingMedicine570QH301-705.51.1 Normal biological development and functioningScience610G-Protein-CoupledUnderpinning researchBiochemistry and Chemical BiologyGeneticsDNA Barcoding, TaxonomicHumansMolecularTaxonomicHealth sciencesHEK293 CellsBiochemistry and Cell BiologyGeneric health relevanceCloning

Sustainable Development Goals

SDG 2: 2. Zero hungerSDG 7: 7. Clean energy