Pilot corpus: NIH-funded biomedical datasets. Any DOI can be scored on demand — network effects sharpen as coverage grows.

Mechanism of Action and Target Identification: A Matter of Timing in Drug Discovery

iScience(2020)10.1016/j.isci.2020.101487Source: DataRank Database

Mechanism of Action and Target Identification: A Matter of Timing in Drug Discovery is a research paper published in iScience (2020). On theSindex it has a DataRank of 2.1. It has been cited 84 times, with 76 citing works in its 1-hop citation network.

N/A

2.1DataRank · unranked

Scored on demand from live citation data

Open Access84 citations · 76 citing works in its network

Download PDF

Cite:

Linked data & code

doi

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (1 grants)Impact (FWCI 5.17)OA: goldTopics (28)Linked Datasets (12)DataCite Reuse (12)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

FAIR checklist signals are shown for context only and do not affect DataRank scoring.

Run a calibrated FAIR evaluation for this paper →

We only score data papers we can read in full — never from an abstract alone.

DataRank Breakdown

Base Score 32%Citation Network 68%

Base Score Contribution

0.666

From this paper's citation signal

Citation Network Contribution

1.4

From 59 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 76 citers.

μMap Photoproximity Labeling Enables Small Molecule Binding Site Mapping
Journal of the American Chemical Society202371 citations47 referencesContributes 0.091
Computer-Aided Drug Design of Natural Candidates for the Treatment of Non-Communicable Diseases
Evidence-based Complementary and Alternative Medicine20221 citations10 referencesContributes 0.069
The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures
BMC Genomics20228 citations33 referencesContributes 0.067
Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism
Bioorganic Chemistry202115 citations47 referencesContributes 0.059
Measuring Protein Aggregation and Stability Using High-Throughput Biophysical Approaches
Frontiers in Molecular Biosciences202220 citations52 referencesContributes 0.059

Authors (1)

Ronald L. Davis ORCID

Live enrichment

PubMed:32891054 PMC:PMC7479624 OpenAlex:https://openalex.org/W3061010776

National Institutes of Health

Grant: 5R01MH109957

FWCI

5.17

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttp://www.cell.com/article/S2589004220306799/pdf

publisherhttp://www.cell.com/article/S2589004220306799/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2589004220306799?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2589004220306799?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.isci.2020.101487

Fields of Study

Computational Drug Discovery MethodsBiosimilars and Bioanalytical MethodsPharmacogenetics and Drug Metabolism

Keywords

Drug discoveryMechanism (biology)Identification (biology)ViewpointsAction (physics)Computational biologyDrug actionDrugPerspective (graphical)Mechanism of actionData scienceComputer scienceCognitive scienceBioinformaticsPharmacologyMedicinePsychologyBiologyEpistemologyArtificial intelligenceEcologyGeneticsPhilosophyHealth SciencesPharmaceutical Science

Sustainable Development Goals

SDG 0: Good health and well-being

Additional file 1 of The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures

10.6084/m9.figshare.19350012.v1figshare

Additional file 1 of The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures

10.6084/m9.figshare.19350012figshare

Additional file 2 of The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures

10.6084/m9.figshare.19350015.v1figshare

Additional file 2 of The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures

10.6084/m9.figshare.19350015figshare

Additional file 3 of The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures

10.6084/m9.figshare.19350018.v1figshare

Additional file 3 of The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures

10.6084/m9.figshare.19350018figshare

Additional file 4 of The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures

10.6084/m9.figshare.19350021.v1figshare

Additional file 4 of The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures

10.6084/m9.figshare.19350021figshare

Additional file 1 of Mechanism of action, potency and efficacy: considerations for cell therapies

10.6084/m9.figshare.25744317.v1figshare

Additional file 1 of Mechanism of action, potency and efficacy: considerations for cell therapies

10.6084/m9.figshare.25744317figshare

Additional file 2 of Mechanism of action, potency and efficacy: considerations for cell therapies

10.6084/m9.figshare.25744470.v1figshare

Additional file 2 of Mechanism of action, potency and efficacy: considerations for cell therapies

10.6084/m9.figshare.25744470figshare

Related Papers (10)

Genetically proxied impaired GIPR signaling and risk of 6 cancers

N/A

0.330DataRank · unranked

iScience(2023)

co-citedsame journal

10.1016/j.isci.2023.106848

The MR-Base platform supports systematic causal inference across the human phenome

N/A

1.4DataRank · unranked

eLife(2018)

co-cited

10.7554/elife.34408

A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding

N/A

4.2DataRank · unranked

Science(2020)

co-cited

10.1126/science.abb7709

Accelerating Therapeutics for Opportunities in Medicine: A Paradigm Shift in Drug Discovery

Frontiers in Pharmacology(2020)

co-cited

10.3389/fphar.2020.00770

ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study

N/A

1.2DataRank · unranked

Royal Society Open Science(2020)

co-cited

10.1098/rsos.200958

The trans-ancestral genomic architecture of glycemic traits

N/A

1.0DataRank · unranked

Nature Genetics(2021)

co-cited

10.1038/s41588-021-00852-9

Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease

N/A

4.0DataRank · unranked

Nature Communications(2021)

co-cited

10.1038/s41467-021-25703-3

The Genomics of Heart Failure: Design and Rationale of the HERMES Consortium

Top 24%

0.829DataRank

ESC Heart Failure(2021)

co-cited

10.1002/ehf2.13517

Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia

N/A

1.7DataRank · unranked

Nature Communications(2022)

co-cited

10.1038/s41467-022-35157-w

Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance

N/A

0.360DataRank · unranked

BMC Medicine(2023)

co-cited

10.1186/s12916-023-03047-7

Mechanism of Action and Target Identification: A Matter of Timing in Drug Discovery

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (1)

Funding (1 grants)

Impact

Open Access

Topics

Linked Datasets (12)

Annotations (Europe PMC)

Related Papers (10)