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ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study

Royal Society Open Science(2020)10.1098/rsos.200958Source: DataRank Database

ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study is a research paper published in Royal Society Open Science (2020). On theSindex it has a DataRank of 1.2. It has been cited 19 times, with 14 citing works in its 1-hop citation network.

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1.2DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access19 citations · 14 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

figshare10.6084/m9.figshare.c.5205231

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (18 grants)Impact (FWCI 0.41)OA: goldTopics (49)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 38%Citation Network 62%

Base Score Contribution

0.449

From this paper's citation signal

Citation Network Contribution

0.738

From 14 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 14 citers.

Antihypertensive medication uses and serum ACE2 levels
medRxiv202019 citations17 referencesContributes 0.176
Plasma ACE2 and risk of death or cardiometabolic diseases: a case-cohort analysis
The Lancet2020170 citations38 referencesContributes 0.135
Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes
Frontiers in Genetics202075 citations36 referencesContributes 0.120
Renin–angiotensin system blockers and susceptibility to COVID-19: an international, open science, cohort analysis
The Lancet Digital Health2020130 citations61 referencesContributes 0.080
Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes
Genome Medicine202254 citations56 referencesContributes 0.072

Authors (33)

Marios Arvanitis ORCID,Paul Carter ORCID,Ana I. Hernández Cordero ORCID,Brian Jo ORCID,Ville Karhunen ORCID

Live enrichment

PubMed:33391794 PMC:PMC7735342 OpenAlex:https://openalex.org/W3105523962

Wellcome Trust

Grant: 204623/Z/16/Z

British Heart Foundation

Grant: RE/18/4/34215

British Heart Foundation

Grant: RG/13/13/30194

Wellcome Trust

Grant: 203928/Z/16/Z

National Institute for Health Research (NIHR)

Grant: ACF-2017-14-503

National Institute for Health Research (NIHR)

Grant: ACF-2018-14-003

Cancer Research UK

Grant: 19169

British Heart Foundation

Grant: RG/18/13/33946

National Institute for Health Research (NIHR)

Grant: COVID-19-RECPLAS

Medical Research Council

Grant: MC_UU_00002/7

Medical Research Council

Grant: MR/L003120/1

Large-scale integrative studies of risk factors in coronary heart disease: from discovery to application

Medical Research Council

Grant: MR/S004068/2

Medical Research Council

Grant: HDR-9004

Medical Research Council

Grant: MR/S004068/1

An integrated genetic and proteomic approach to understanding cardiovascular disease aetiology

European Commission

Grant: 116074

Big Data 4 Better Hearts - Sofia ref.: 116074

European Commission

Grant: 721567

Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe

Wellcome Trust

Grant: 203928

The Imperial Immunity, Inflammation, Infection and Informatics (4i) Clinician Scientist Programme

Wellcome Trust

Grant: 204623

Genetics and causality: towards more accessible and more reliable Mendelian randomization investigations

FWCI

0.41

Citation Percentile

0.8%

Citation Trend

2020

2021

2022

2023

2024

goldLicense: cc-by

journalhttps://royalsocietypublishing.org/doi/pdf/10.1098/rsos.200958

publisherhttps://royalsocietypublishing.org/doi/pdf/10.1098/rsos.200958

publisherhttps://royalsocietypublishing.org/doi/full-xml/10.1098/rsos.200958

journalhttps://doi.org/10.1098/rsos.200958

repositoryhttps://pubmed.ncbi.nlm.nih.gov/33391794

Fields of Study

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery Methods0301 basic medicine03 medical and health sciences

Keywords

TMPRSS2Mendelian randomizationAngiotensin-converting enzyme 2BiologyInternal medicineTMPRSS6EndocrinologyImmunologyMedicineDiseaseGeneGeneticsGenotypeSerine proteaseProteaseCoronavirus disease 2019 (COVID-19)Genetic epidemiologyAngiotensin-converting enzyme inhibitorsCovid-19Science610Medical Genetics and Genomics/dk/atira/pure/core/keywords/icepKardiologi och kardiovaskulära sjukdomarHYPERTENSIVE PATIENTSSARS CORONAVIRUSMODULATION/dk/atira/pure/core/keywords/icep; name=ICEPOLMESARTANOUTCOMESScience & TechnologyMultidisciplinaryCARDIOMYOPATHYRECEPTORname=ICEPQ600Genetics and GenomicsMedicinsk genetik och genomikMultidisciplinary SciencesScience & Technology - Other TopicsHEART-FAILURECONVERTING ENZYME 2Cardiology and Cardiovascular Disease

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being