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Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin2 G protein–coupled receptor

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.104785Source: DataRank Database

Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin2 G protein–coupled receptor is a research paper published in Journal of Biological Chemistry (2023). On theSindex it has a DataRank of 0. It has been cited 12 times.

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Open Access12 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (7 grants)Impact (FWCI 1.33)OA: goldTopics (61)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Jordan A. Karim ORCID,Peyton H. Gordon,James Lennon ORCID,Alex Dickson ORCID,Augen A. Pioszak ORCID

Live enrichment

PubMed:37146967 PMC:PMC10248883 OpenAlex:https://openalex.org/W4367856780

National Institute of General Medical Sciences

Grant: R01GM104251

National Institute of General Medical Sciences

Grant: R01GM130794

National Science Foundation

Grant: DMS1761320

National Institutes of Health

Grant: 5R01GM104251-03

RAMP-altered Class B GPCR Hormone Recognition

National Institutes of Health

Grant: 5R01GM130794-07

Revealing pathways and kinetics of molecular recognition with advanced molecular simulation algorithms

National Science Foundation

Grant: 1761320

Kinetics-Driven Drug Discovery Using Persistent Homology, Rare-Event Molecular Dynamics and Experimental Data

National Institutes of Health

FWCI

1.33

Citation Percentile

0.8%

Citation Trend

2024

2025

goldLicense: cc-by-nc-nd

journalhttp://www.jbc.org/article/S0021925823018136/pdf

publisherhttp://www.jbc.org/article/S0021925823018136/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925823018136?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925823018136?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2023.104785

Fields of Study

Neuropeptides and Animal PhysiologyReceptor Mechanisms and SignalingCancer, Stress, Anesthesia, and Immune Response0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Cyclic AMPAnimalsChlorocebus aethiopsHumansModels, MolecularSignal TransductionCalcitonin Gene-Related PeptideCOS CellsPeptide HormonesReceptors, G-Protein-CoupledAdrenomedullinProtein StabilityMolecular Dynamics SimulationHEK293 CellsReceptor Activity-Modifying ProteinsReceptors, AdrenomedullinCalcitonin Receptor-Like Protein

Keywords

AdrenomedullinAgonistEndogenyReceptorChemistryInternal medicineEndogenous agonistEndocrinologyPharmacologyMedicineBiochemistrySignalingMolecular dynamicsPeptide hormoneMolecular PharmacologyBioluminescence Resonance Energy Transfer (Bret)Receptor Structure–functionG Protein–coupled Receptor (Gpcr)Kinetic SelectivityLong Residence Time AgonistModels, MolecularProtein StabilityCalcitonin Gene-Related PeptidePeptide HormonesCalcitonin Receptor-Like ProteinMolecular Dynamics SimulationArticleReceptor Activity-Modifying ProteinsReceptors, G-Protein-CoupledHEK293 CellsChlorocebus aethiopsCOS CellsCyclic AMPAnimalsHumansReceptors, AdrenomedullinResearch ArticleSignal Transduction

Sustainable Development Goals

SDG 3: 3. Good health

Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin2 G protein–coupled receptor

FAIR Checklist

Authors (6)

Funding (7 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)