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GoLoco/GPR motif-dependent regulation of Rap1GAP1 by Gαo is disrupted by Gαo encephalopathy variants

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110446Source: DataRank Database

GoLoco/GPR motif-dependent regulation of Rap1GAP1 by Gαo is disrupted by Gαo encephalopathy variants is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Open Access3 citations

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Enrichment:Funding (4 grants)Impact (FWCI 1.59)OA: goldTopics (40)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Naincy R. Chandan ORCID,Beiyun Wang,Elaine Qu,Alan V. Smrcka ORCID,Nathalie Momplaisir

Live enrichment

PubMed:40615045 PMC:PMC12329598 OpenAlex:https://openalex.org/W4411958537

National Science Foundation

Grant: DGE-2241144

NIH National Institute of General Medical Sciences

Grant: R35GM127303

National Institutes of Health

University of Michigan

FWCI

1.59

Citation Percentile

0.8%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://www.jbc.org/article/S0021-9258(25)02296-3/pdf

publisherhttps://www.jbc.org/article/S0021-9258(25)02296-3/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925825022963?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925825022963?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2025.110446

Fields of Study

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase SignalingCellular transport and secretionGTPase-Activating ProteinsHumansAnimalsGTP-Binding Protein alpha Subunits, Gi-GoRatsPC12 CellsAmino Acid MotifsChromograninsMutation

MeSH Terms

AnimalsChromograninsHumansMutationPC12 CellsGTP-Binding Protein alpha Subunits, Gi-GoGTPase-Activating ProteinsAmino Acid MotifsRats

Keywords

Motif (music)EncephalopathyChemistryBiologyCell biologyGeneticsInternal medicineMedicinePhilosophyEpilepsyheterotrimeric G proteinprotein-protein interactionsBretRap1gapAlpha SubunitsProximity LabelingGoloco MotifGnao1G Protein-regulatory Motif

Sustainable Development Goals

SDG 0: Zero hunger

GoLoco/GPR motif-dependent regulation of Rap1GAP1 by Gαo is disrupted by Gαo encephalopathy variants

FAIR Checklist

Authors (5)

Funding (4 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)