Alan V. Smrcka

Biochemistry, Genetics and Molecular BiologyNeuroscienceMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

2in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 2 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 26 papers. Top paper: “Regulation of Phosphatidylinositol-specific Phospholipase C at the Nuclear Envelope in Cardiac Myocytes”.

Regulation of Phosphatidylinositol-specific Phospholipase C at the Nuclear Envelope in Cardiac Myocytes

Journal of Cardiovascular Pharmacology(2015)10.1097/fjc.0000000000000195

N/A

1.1DataRank · unranked

20 citations

Alan V. Smrcka

Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G q

Science(1991)10.1126/science.1846707

N/A

1.0DataRank · unranked

903 citations

John R. Hepler, Kendall O. Brown, Paul C. Sternweis, Alan V. Smrcka

Activation of Phospholipase C β by Gβγ and Gαq Involves C-Terminal Rearrangement to Release Autoinhibition

Structure(2020)10.1016/j.str.2020.04.012

N/A

0.564DataRank · unranked

42 citations

Meredith L. Jenkins, Gregory G. Tall, John E. Burke, Alan V. Smrcka, Isaac J. Fisher

Phospholipase C‐ε defines a PACAP‐stimulated pathway for secretion in the chromaffin cell

Journal of Neuroendocrinology(2023)10.1111/jne.13255

N/A

0.396DataRank · unranked

13 citations

Breanna L. Coffman, Rebecca L. Brindley, Jason D. Galpin, Christopher A. Ahern, Kevin Currie +4 more

Biasing Gβγ Downstream Signaling with Gallein Inhibits Development of Morphine Tolerance and Potentiates Morphine-Induced Nociception in a Tolerant State

Molecular Pharmacology(2024)10.1124/molpharm.124.000875

N/A

0.312DataRank · unranked

7 citations

Alan V. Smrcka, Emily M. Jutkiewicz, Gissell A. Sanchez

GoLoco/GPR motif-dependent regulation of Rap1GAP1 by Gαo is disrupted by Gαo encephalopathy variants

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110446

N/A

0.241DataRank · unranked

4 citations

Naincy R. Chandan, Beiyun Wang, Elaine Qu, Alan V. Smrcka, Nathalie Momplaisir

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Scientific Reports(2024)10.1038/s41598-024-70321-w

N/A

0.165DataRank · unranked

2 citations

Izhar Wallach, Denzil Bernard, Kong T. Nguyen, Gregory Ho, Adrian R. Morrison +95 more

Biasing G protein βγ subunit downstream signaling enhances the analgesic effects of endogenous opioid receptor agonists during nitroglycerin-induced thermal hypersensitivity

Molecular Pharmacology(2025)10.1016/j.molpha.2025.100068

N/A

0.165DataRank · unranked

2 citations

Alan V. Smrcka, Emily M. Jutkiewicz, Farzanna Mohamed

A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state

Nature Communications(2024)10.1038/s41467-024-50964-z

N/A

0DataRank · unranked

17 citations

B. Krumm, Nicholas J. Kapolka, W.H. Ludlam, Meng Cui, Sepehr Mani +15 more

Stabilization of interdomain interactions in G protein α subunits as a determinant of Gαi subtype signaling specificity

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.107211

N/A

0DataRank · unranked

6 citations

Wenyuan Wei, Elizaveta Mukhaleva, Sai Pranathi Meda Venkata, Naincy R. Chandan, Saji Abraham +5 more

Phospholipase C epsilon-1 (PLCƐ1) mediates macrophage activation and protection against tuberculosis

Infection and Immunity(2024)10.1128/iai.00495-23

N/A

0DataRank · unranked

5 citations

Shyamala Thirunavukkarasu, Javier Rangel‐Moreno, Mushtaq Ahmed, Rosemary V. Swanson, Stanley Kimbung Mbandi +5 more

A PACAP-activated network for secretion requires coordination of Ca 2+ influx and Ca 2+ mobilization

Molecular Biology of the Cell(2024)10.1091/mbc.e24-02-0083

N/A

0DataRank · unranked

3 citations

Nicole Bell, Breanna L. Coffman, Agustin A. Rabino, Rafael García‐Mata, Paul J. Kammermeier +6 more

Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.05.11.593568

N/A

0DataRank · unranked

1 citations

Juliana Bragazzi Cunha, Chinmay Raut, Michael Burroughs, Sascha N. Goonewardena, Alan V. Smrcka +3 more

A PACAP-activated network for secretion requires coordination of Ca 2+ influx and Ca 2+ mobilization

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.01.03.574069

N/A

0DataRank · unranked

0 citations

Nicole Bell, Breanna L. Coffman, Agustin A. Rabino, Rafael García‐Mata, Paul J. Kammermeier +6 more

A universal allosteric mechanism for G protein activation

Carolina Digital Repository (University of North Carolina at Chapel Hill)(2024)10.17615/sk39-ch26

N/A

0DataRank · unranked

0 citations

Natalie Hewitt, Nagarajan Vaidehi, Guowei Yin, Kevin M. Knight, Sharon L. Campbell +5 more

Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening

Atherosclerosis(2025)10.1016/j.atherosclerosis.2025.119174

N/A

0DataRank · unranked

3 citations

Juliana Bragazzi Cunha, Chinmay Raut, Michael Burroughs, Hitarthi Vyas, Kyle Leix +5 more

Neuromodulation of voltage-gated sodium channels by Gβ1γ2 subunits: Implications for GNB1-linked encephalopathy

Neurobiology of Disease(2025)10.1016/j.nbd.2025.106990

N/A

0DataRank · unranked

1 citations

Samantha L. Hodges, Luis F. Lopez‐Santiago, Yukun Yuan, Julie Ziobro, Joe Minton +7 more

GPR97/ADGRG3 is activated by its tethered peptide agonist and not by steroids to induce neutrophil polarization and migration

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.09.11.675646

N/A

0DataRank · unranked

1 citations

Frank E. Kwarcinski, Naincy R. Chandan, Riya Gandhi, Yuling Feng, Michael Holinstat +4 more

A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state

UNC Libraries(2025)10.17615/p1he-g624

N/A

0DataRank · unranked

0 citations

Tyler J. Lefevre, Ning Ma, Kevin M. Knight, Alan V. Smrcka, Sepehr Mani +15 more

A Universal Allosteric Mechanism for G Protein Activation

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.11.15.383679

N/A

0DataRank · unranked

6 citations

Soumadwip Ghosh, Sharon L. Campbell, Tyler J. Lefevre, Reid H. J. Olsen, Alan V. Smrcka +5 more

Identification of G Protein α i Signaling Partners by Proximity Labeling Reveals a Network of Interactions that Includes PDZ-RhoGEF

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.07.15.452545

N/A

0DataRank · unranked

3 citations

Saji Abraham, Shuvasree SenGupta, Carole A. Parent, Alan V. Smrcka, Naincy R. Chandan

Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1–Dependent Functions in Neutrophils

Molecular Pharmacology(2020)10.1124/mol.119.117556

N/A

0DataRank · unranked

24 citations

Naincy R. Chandan, Alan Y. Hsu, Prateek Sharma, Qing Deng, Alan V. Smrcka +2 more

A naturally occurring membrane-anchored Gαs variant, XLαs, activates phospholipase Cβ4

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102134

N/A

0DataRank · unranked

6 citations

Joseph Loomis, Saji Abraham, Qing He, Murat Bastepe, Alan V. Smrcka +1 more

PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells

The Journal of General Physiology(2022)10.1085/jgp.202213180

N/A

0DataRank · unranked

9 citations

Ramkumar Mohan, Xiaohuan Chen, Breanna L. Coffman, Mounir Bendahmane, Lester Watch +10 more

Identifying Novel Signaling Mechanisms Downstream of G q ‐Coupled Receptors

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.r2620

N/A

0DataRank · unranked

0 citations

Naincy R. Chandan, Matthew J. Brody, Alan V. Smrcka, Joseph Loomis

SMARCD3: A Link Between G??q and Chromatin Remodeling?

Journal of Pharmacology and Experimental Therapeutics(2023)10.1124/jpet.122.216070

N/A

0DataRank · unranked

0 citations

Naincy R. Chandan, Alan V. Smrcka, Joseph Loomis