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APE1 active site residue Asn174 stabilizes the AP site and is essential for catalysis

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110655Source: DataRank Database

APE1 active site residue Asn174 stabilizes the AP site and is essential for catalysis is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0.241. It has been cited 4 times, with 2 citing works in its 1-hop citation network.

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0.241DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access4 citations · 2 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

PDB9DP1 9DP4 9DP3 9DP2

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (7 grants)Impact (FWCI 1.63)OA: goldTopics (41)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.241

From this paper's citation signal

Citation Network Contribution

From 0 citing papers with measurable signal

This paper's DataRank is currently driven only by its base citation score. None of the citing papers had measurable citation signal.

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Authors (6)

Nicole M. Hoitsma ORCID,Spencer H. Thompson ORCID,Veniamin A. Borin ORCID,Pratul K. Agarwal ORCID,Bret Freudenthal ORCID

Live enrichment

PubMed:40902980 PMC:PMC12557600 OpenAlex:https://openalex.org/W4413890546

National Institute of General Medical Sciences

Grant: R35GM128562

National Institute of General Medical Sciences

Grant: R01GM148886

National Institute of General Medical Sciences

Grant: P30 GM124169-01

Damon Runyon Cancer Research Foundation

Grant: DRG-2499-23

Office of Science

Grant: DE-AC02-05CH11231

NIGMS NIH HHS

Grant: P30 GM124169

National Institutes of Health

FWCI

1.63

Citation Percentile

0.8%

Citation Trend

2026

goldLicense: cc-by

journalhttps://doi.org/10.1016/j.jbc.2025.110655

publisherhttps://doi.org/10.1016/j.jbc.2025.110655

publisherhttps://api.elsevier.com/content/article/PII:S0021925825025074?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925825025074?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40902980

Fields of Study

Ubiquitin and proteasome pathwaysBiochemical and Molecular ResearchEndoplasmic Reticulum Stress and DiseaseDNA-(Apurinic or Apyrimidinic Site) LyaseCatalytic DomainHumansCrystallography, X-RayHydrogen BondingMolecular Dynamics SimulationCatalysisAsparagineDNAKineticsDNA RepairAmino Acid Substitution

MeSH Terms

AsparagineCatalysisDNADNA RepairHumansHydrogen BondingKineticsCrystallography, X-RayAmino Acid SubstitutionCatalytic DomainDNA-(Apurinic or Apyrimidinic Site) LyaseMolecular Dynamics Simulation

Keywords

Active siteResidue (chemistry)ChemistryCatalysisBinding siteStereochemistryBiophysicsBiochemistryBiologyDNA repairEnzyme structureEnzyme CatalysisBase Excision Repair (Ber)Dna Endonuclease

APE1 active site residue Asn174 stabilizes the AP site and is essential for catalysis

FAIR Checklist

DataRank Breakdown

Authors (6)

Funding (7 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)