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Glucose starvation induces a switch in the histone acetylome for activation of gluconeogenic and fat metabolism genes

Molecular Cell(2022)10.1016/j.molcel.2021.12.015Source: DataRank Database

Glucose starvation induces a switch in the histone acetylome for activation of gluconeogenic and fat metabolism genes is a research paper published in Molecular Cell (2022). On theSindex it has a DataRank of 2.8. It has been cited 94 times, with 92 citing works in its 1-hop citation network.

N/A

2.8DataRank · unranked

Scored on demand from live citation data

Open Access94 citations · 92 citing works in its network

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Linked data & code

geo gen uniprot pdb doi

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (10 grants)Impact (FWCI 6.20)OA: hybridTopics (70)IDs (PubMed, PMC, OpenAlex)Annotations (5)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 24%Citation Network 76%

Base Score Contribution

0.683

From this paper's citation signal

Citation Network Contribution

2.1

From 70 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 92 citers.

Chromatin as a metabolic organelle: Integrating the cellular flow of carbon with gene expression
Molecular Cell20228 citations9 referencesContributes 0.244
Does chromatin function as a metabolite reservoir?
Trends in Biochemical Sciences202218 citations15 referencesContributes 0.196
Response to letter-to-the-editor: “Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA”
Molecular Metabolism20242 citations9 referencesContributes 0.122
Docosahexaenoic Acid Alters Lipid Metabolism Processes via H3K9ac Epigenetic Modification in Dairy Goat
Journal of Agricultural and Food Chemistry202322 citations44 referencesContributes 0.071
PPARs as Key Transcription Regulators at the Crossroads of Metabolism and Inflammation
International Journal of Molecular Sciences20247 citations34 referencesContributes 0.061

Authors (6)

Benjamin M. Sutter ORCID,Holly Ruess ORCID,Spencer Barnes ORCID,Venkat S. Malladi ORCID,Benjamin P. Tu ORCID

Live enrichment

PubMed:34995509 PMC:PMC8794035 OpenAlex:https://openalex.org/W4206484283

National Institutes of Health

Grant: R01CA185169

NIGMS

Grant: R35GM136370

Cancer Prevention and Research Institute of Texas

Grant: RP150596

NIGMS NIH HHS

Grant: R01 GM094314

National Institutes of Health

Grant: 5R01CA185169-03

Targeting Acetyl-CoA Metabolism for the Discovery of New Anti-Cancer Therapeutics

National Institutes of Health

Grant: 5R35GM136370-02

Metabolic signals regulating cell growth versus survival

NINDS

Welch Foundation

Howard Hughes Medical Institute

FWCI

6.20

Citation Percentile

1.0%

Citation Trend

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttp://www.cell.com/article/S1097276521010777/pdf

publisherhttp://www.cell.com/article/S1097276521010777/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1097276521010777?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1097276521010777?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.molcel.2021.12.015

Fields of Study

Histone Deacetylase Inhibitors ResearchUbiquitin and proteasome pathwaysPlant Gene Expression Analysis0301 basic medicine03 medical and health sciencesAcetyl Coenzyme AAcetylationGene Expression Regulation, FungalGluconeogenesisGlucoseHistone AcetyltransferasesHistone DeacetylasesHistonesLipid MetabolismProtein Processing, Post-TranslationalSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTrans-Activatorsp300-CBP-Associated Factor

MeSH Terms

p300-CBP-Associated FactorAcetyl Coenzyme AAcetylationGluconeogenesisGlucoseHistone DeacetylasesHistonesProtein Processing, Post-TranslationalSaccharomyces cerevisiaeTrans-ActivatorsGene Expression Regulation, FungalSaccharomyces cerevisiae ProteinsLipid MetabolismHistone Acetyltransferases

Keywords

AcetylationBiologyHistoneHistone AcetyltransferasesHistone deacetylaseSAP30Histone acetyltransferaseHistone H2ABiochemistryHDAC11Histone deacetylase 2HDAC4Histone methyltransferaseHistone deacetylase 5Cell biologyGeneTranscriptionFat metabolismgluconeogenesisHistone acetylationSagaAcetyl-coaGlucose StarvationEnvironmental Stress ResponseGcn5pRpd3pSaccharomyces cerevisiae Proteinsp300-CBP-Associated FactorSaccharomyces cerevisiaeLipid MetabolismHistone DeacetylasesHistonesGlucoseAcetyl Coenzyme AGene Expression Regulation, FungalTrans-ActivatorsProtein Processing, Post-Translational

Sustainable Development Goals

SDG 2: 2. Zero hunger