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Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions

Neurobiology of Disease(2024)10.1016/j.nbd.2024.106411Source: DataRank Database

Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions is a research paper published in Neurobiology of Disease (2024). On theSindex it has a DataRank of 0. It has been cited 27 times.

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Enrichment:Funding (13 grants)Impact (FWCI 4.68)OA: goldTopics (51)Linked Datasets (10)DataCite Reuse (10)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

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Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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Authors (8)

Christopher J. Kemp,Joseph R. Patterson ORCID,Jacob W. Howe ORCID,Kathy Steece‐Collier ORCID,Kelvin C. Luk ORCID

Live enrichment

PubMed:38228253 PMC:PMC10869642 OpenAlex:https://openalex.org/W4390956425

National Institutes of Health

Grant: NS099416

National Institutes of Health

Grant: NS111333

National Institutes of Health

Grant: NS121393

National Institutes of Health

Grant: T32GM092715

NINDS NIH HHS

Grant: R21 NS111333

NINDS NIH HHS

Grant: R21 NS121393

NINDS NIH HHS

Grant: R33 NS099416

NINDS NIH HHS

Grant: R21 NS099416

National Institutes of Health

Grant: 1R21NS111333-01A1

Synucleinopathy triggered neuroinflammation

National Institutes of Health

Grant: 1R21NS099416-01A1

The Rat Pre-Formed Alpha-Synuclein Fibril Model of Parkinson's Disease

National Institutes of Health

Grant: 5T32GM092715-04

Integrative Training in the Pharmacological Sciences

National Institutes of Health

Grant: 1R21NS121393-01

Targeting Complement Component 3 in a Model of Synucleinopathy

Midwestern State University

FWCI

4.68

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.nbd.2024.106411

publisherhttps://doi.org/10.1016/j.nbd.2024.106411

publisherhttps://api.elsevier.com/content/article/PII:S096999612400010X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S096999612400010X?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38228253

Fields of Study

Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments0301 basic medicine03 medical and health sciences0302 clinical medicine

MeSH Terms

SynucleinopathiesNeuroinflammatory DiseasesAnimalsNeurogliaParkinson DiseaseSubstantia NigraIn Situ Hybridization, FluorescenceComplement C1 Inhibitor ProteinRatsalpha-SynucleinDopaminergic NeuronsTranscriptome

Keywords

Substantia nigraPars compactaMicrogliaNeuroinflammationBiologyCell biologyDownregulation and upregulationGene expressionDopamineNeuroscienceImmunologyInflammationGeneDopaminergicBiochemistryAstrocyteParkinson's Diseasealpha-SynucleinGliaSynucleinopathySynucleinopathiesDopaminergic NeuronsNeurosciences. Biological psychiatry. NeuropsychiatryParkinson DiseaseArticleRatsNeuroinflammatory DiseasesAnimalsTranscriptomeComplement C1 Inhibitor ProteinNeurogliaIn Situ Hybridization, FluorescenceRC321-571

Sustainable Development Goals

SDG 0: Life below water

Additional file 5 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition

10.6084/m9.figshare.26712380.v1figshare

Additional file 5 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition

10.6084/m9.figshare.26712380figshare

Additional file 4 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition

10.6084/m9.figshare.26712377figshare

Additional file 3 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition

10.6084/m9.figshare.26712374figshare

Additional file 4 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition

10.6084/m9.figshare.26712377.v1figshare

Additional file 1 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition

10.6084/m9.figshare.26712368figshare

Additional file 2 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition

10.6084/m9.figshare.26712371.v1figshare

Additional file 1 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition

10.6084/m9.figshare.26712368.v1figshare

Additional file 2 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition

10.6084/m9.figshare.26712371figshare

Additional file 3 of Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition

10.6084/m9.figshare.26712374.v1figshare

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Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions

FAIR Checklist

Authors (8)

Funding (13 grants)

Impact

Open Access

Topics

Linked Datasets (10)

Annotations (Europe PMC)

Related Papers (8)