Kelvin C. Luk

Also affiliated with Institute for Neurodegenerative Disorders, Institute on Aging, University of Pennsylvania

MedicineNeuroscience

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 35 papers. Top paper: “Cell-to-Cell Transmission of Tau and α-Synuclein”.

Cell-to-Cell Transmission of Tau and α-Synuclein

Trends in Molecular Medicine(2020)10.1016/j.molmed.2020.03.012

N/A

0.754DataRank · unranked

151 citations

Maiko Uemura, Kelvin C. Luk, Virginia M.‐Y. Lee, John Q. Trojanowski, Norihito Uemura

Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread

The Journal of Neuroscience(2024)10.1523/jneurosci.0877-24.2024

N/A

0.165DataRank · unranked

2 citations

Kevt’her Hoxha, Damian Mozier, Abigail Insana, Ethan Farber, Lakshmi Changolkar +11 more

Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy

Acta Neuropathologica Communications(2020)10.1186/s40478-020-01026-0

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0DataRank · unranked

70 citations

Teresa L. Stackhouse, Leah J. Weston, Patrick C. Kerstein, Valerie R. Osterberg, Clàudia López +6 more

TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson’s Disease

Cell Reports(2020)10.1016/j.celrep.2020.108418

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0DataRank · unranked

65 citations

Dilshan S. Harischandra, Shivani Ghaisas, Pengfei Zhang, Wil Prall, Liangqian Huang +9 more

Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits

Neurobiology of Disease(2020)10.1016/j.nbd.2020.104947

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0DataRank · unranked

46 citations

Joseph Kochmanski, Sarah VanOeveren, Allyson Cole-Strauss, Christopher J. Kemp, Joseph R. Patterson +10 more

Snca -GFP Knock-In Mice Reflect Patterns of Endogenous Expression and Pathological Seeding

eNeuro(2020)10.1523/eneuro.0007-20.2020

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0DataRank · unranked

24 citations

Yuling Liang, Tobias Raabe, Angela Lo, Mian Horvath, Bin Zhang +4 more

Potent inhibitors of toxic alpha-synuclein oligomers identified via cellular time-resolved FRET biosensor

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.01.09.900845

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0DataRank · unranked

3 citations

Elly E. Liao, Mian Horvath, Malaney C. Young, Chih Hung Lo, Roland Brown +5 more

Perturbation of in vivo neural activity following α-Synuclein seeding in the olfactory bulb

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.04.17.045013

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0DataRank · unranked

1 citations

María del Mar Cortijo, Elizabeth R. Roberts, Tamara L. Suggs, Heather B. Stover, José I. Pena-Bravo +5 more

Snca -GFP knock-in mice reflect patterns of endogenous expression and pathological seeding

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.05.077321

N/A

0DataRank · unranked

1 citations

Yuling Liang, Tobias Raabe, Angela Lo, Mian Horvath, Bin Zhang +4 more

Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns

Brain(2021)10.1093/brain/awab440

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0DataRank · unranked

71 citations

Bratislav Misic, Ying‐Qiu Zheng, Zhen-Qi Liu, Alaa Abdelgawad, Nooshin Abbasi +9 more

Dopamine neurons exhibit emergent glutamatergic identity in Parkinson’s disease

Brain(2021)10.1093/brain/awab373

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0DataRank · unranked

48 citations

William S. Conrad, Imre Kovács, Robert A. Rissman, Edward B. Lee, John Q. Trojanowski +6 more

Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100273

N/A

0DataRank · unranked

41 citations

Teresa L. Stackhouse, Kateri J. Spinelli, Sydney Weber Boutros, Elizabeth P. Rose, Valerie R. Osterberg +5 more

Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors

npj Parkinson s Disease(2021)10.1038/s41531-021-00195-6

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0DataRank · unranked

40 citations

Elly E. Liao, Mian Horvath, Prakriti Kalra, Karen Acosta, Malaney C. Young +11 more

Heterozygous GBA D409V and ATP13a2 mutations do not exacerbate pathological α-synuclein spread in the prodromal preformed fibrils model in young mice

Neurobiology of Disease(2021)10.1016/j.nbd.2021.105513

N/A

0DataRank · unranked

27 citations

Liza Bergkvist, Lucas Stetzik, Jennifer A. Steiner, Lindsay Meyerdirk, Emily Schulz +6 more

Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy

Neurotherapeutics(2021)10.1007/s13311-021-01114-6

N/A

0DataRank · unranked

11 citations

Rachel N. Clark, Patrick G. Needham, Kristin M. Miner, Anuj S. Jamenis, Elizabeth A. Eckhoff +7 more

α-Synuclein arginylation in the human brain

Translational Neurodegeneration(2022)10.1186/s40035-022-00295-0

N/A

0DataRank · unranked

18 citations

Buyan Pan, Marie E. Fina, Yun Huang, Marie Shimogawa, Kelvin C. Luk +5 more

Investigating key factors underlying neurodegeneration linked to alpha‐synuclein spread

Neuropathology and Applied Neurobiology(2022)10.1111/nan.12829

N/A

0DataRank · unranked

5 citations

Maja Højvang Sørensen, Krit Lee, Kelvin C. Luk, John Q. Trojanowski, Virginia M.‐Y. Lee +3 more

Rapid iPSC inclusionopathy models shed light on formation, consequence and molecular subtype of α-synuclein inclusions

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.08.515615

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0DataRank · unranked

9 citations

Alain Ndayisaba, Amanda J. Lewis, YuHong Fu, Giselle T. Sagredo, Ludovica Zaccagnini +44 more

A Connection Between DNA Repair Protein APE1, Alpha‐Synucleinopathy, and Biological Sex in Rodents and Humans

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.r3221

N/A

0DataRank · unranked

0 citations

Tarun N. Bhatia, Anuj S. Jamenis, Rachel N. Clark, Nevil Abraham, Dhivyaa Rajasundaram +7 more

α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice

Nature Communications(2023)10.1038/s41467-023-42705-5

N/A

0DataRank · unranked

62 citations

Nicholas P. Marotta, Jahan Ara, Emily S. Meymand, Bin Zhang, Hiroshi Kameda +5 more

A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c00779

N/A

0DataRank · unranked

38 citations

Wai Kit Chia, Chia‐Ju Hsieh, Dinahlee Saturnino Guarino, Thomas J. A. Graham, Zsofia Lengyel‐Zhand +16 more

Developmental exposure to the Parkinson’s disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice

Toxicological Sciences(2023)10.1093/toxsci/kfad086

N/A

0DataRank · unranked

22 citations

Nathan C. Kuhn, Joseph R. Patterson, Anna C. Stoll, S. Zimmerman, Mason R. Kolanowski +6 more

Identification of a Putative α-synuclein Radioligand Using an in silico Similarity Search

Molecular Imaging and Biology(2023)10.1007/s11307-023-01814-9

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0DataRank · unranked

17 citations

Guilong Tian, Zsofia Lengyel‐Zhand, Chia‐Ju Hsieh, Marshall G. Lougee, Aladdin Riad +13 more

The variance in phosphorylated, insoluble ⍺-synuclein in humans, rats, and mice is not mainly driven by biological sex

Acta Neuropathologica(2023)10.1007/s00401-023-02621-w

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0DataRank · unranked

3 citations

Anuj S. Jamenis, Tarun N. Bhatia, Rachel N. Clark, Muslim Abbas Syed, Kelvin C. Luk +2 more

O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.07.531573

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0DataRank · unranked

9 citations

Anne‐Laure Mahul‐Mellier, Binh A. Nguyen, Mian Horvath, Afraah Javed, Eldon R. Hard +11 more

Distinct biological activity of Lewy body α-Synuclein strain in mice

Research Square(2023)10.21203/rs.3.rs-2579805/v1

N/A

0DataRank · unranked

4 citations

Nicholas P. Marotta, Jahan Ara, Emily S. Meymand, Bin Zhang, Hiroshi Kameda +5 more

Microglial depletion does not impact alpha-synuclein aggregation or nigrostriatal degeneration in the rat preformed fibril model

Research Square(2023)10.21203/rs.3.rs-2890683/v1

N/A

0DataRank · unranked

4 citations

Christopher J. Kemp, Joseph R. Patterson, Michael Kubik, Nathan C. Kuhn, Matthew J. Benskey +4 more

O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology

Nature Chemical Biology(2024)10.1038/s41589-024-01551-2

N/A

0DataRank · unranked

83 citations

Anne‐Laure Mahul‐Mellier, Binh A. Nguyen, Mian Horvath, Afraah Javed, Eldon R. Hard +11 more

Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions

Neuron(2024)10.1016/j.neuron.2024.06.002

N/A

0DataRank · unranked

31 citations

Alain Ndayisaba, Amanda J. Lewis, YuHong Fu, Giselle T. Sagredo, Anastasia Kuzkina +49 more

Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions

Neurobiology of Disease(2024)10.1016/j.nbd.2024.106411

N/A

0DataRank · unranked

27 citations

Christopher J. Kemp, Joseph R. Patterson, Jacob W. Howe, Kathy Steece‐Collier, Kelvin C. Luk +3 more

Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons

Science Advances(2024)10.1126/sciadv.adj4767

N/A

0DataRank · unranked

17 citations

Nima Naseri, Sarshan R. Pather, Erinc Hallacli, Alain Ndayisaba, Chris Buenaventura +9 more

Are Preformed Fibrils a Model of Parkinson’s Disease?

Journal of Parkinson s Disease(2024)10.3233/jpd-240228

N/A

0DataRank · unranked

11 citations

Kelvin C. Luk, Amanda L. Woerman

Alpha-Synuclein Conformations in Plasma Distinguish Parkinson’s Disease from Dementia with Lewy Bodies

Research Square(2024)10.21203/rs.3.rs-5033901/v1

N/A

0DataRank · unranked

0 citations

George T. Kannarkat, Rebecca Zack, R. Tyler Skrinak, James F. Morley, Roseanne Davila‐Rivera +13 more

Blood α‐Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies

Annals of Neurology(2025)10.1002/ana.27288

N/A

0DataRank · unranked

4 citations

Rebecca Zack, R. Tyler Skrinak, James F. Morley, Roseanne Davila‐Rivera, Sanaz Arezoumandan +13 more

Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau

Science(2020)10.1126/science.aay8826

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0DataRank · unranked

146 citations

Jessica M. Phan, Boram Kim, Eunran Suh, John Papatriantafyllou, Lakshmi Changolkar +17 more