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Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components

Neuron(2021)10.1016/j.neuron.2021.03.026Source: DataRank Database

Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components is a research paper published in Neuron (2021). On theSindex it has a DataRank of 4.9. It has been cited 222 times, with 200 citing works in its 1-hop citation network.

N/A

4.9DataRank · unranked

Scored on demand from live citation data

Open Access222 citations · 200 citing works in its network

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geo cellosaurus hpa uniprot doi

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (17 grants)Impact (FWCI 12.14)OA: bronzeTopics (97)Linked Datasets (14)DataCite Reuse (14)IDs (PubMed, PMC, OpenAlex)Annotations (5)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 17%Citation Network 83%

Base Score Contribution

0.811

From this paper's citation signal

Citation Network Contribution

4.1

From 169 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 200 citers.

Tau heckles speckles: A pathogenic mechanism in tauopathy?
Neuron20213 citations10 referencesContributes 0.139
SRRM2 phase separation drives assembly of nuclear speckle subcompartments
Cell Reports202447 citations31 referencesContributes 0.125
Enrichment of novel Tau isoform with altered biochemical properties in Alzheimer’s disease
Neural Regeneration Research20232 citations12 referencesContributes 0.092
Higher Intron Retention Levels in Female Alzheimer's Brains May Be Linked to Disease Prevalence
Aging Cell20255 citations20 referencesContributes 0.090
Nuclear Tau accumulation in Alzheimer’s disease
Advances in protein chemistry and structural biology202415 citations32 referencesContributes 0.087

Authors (10)

Felicia K. Ooi ORCID,Nadine Bakkar ORCID,Jacob I. Ayers ORCID,Amanda L. Woerman ORCID,Joshua Wheeler ORCID

Live enrichment

PubMed:33848474 PMC:PMC8141031 OpenAlex:https://openalex.org/W3154112996

NIST

Grant: 70NANB15H226

National Institutes of Health

Grant: 2P01AG002132-39

Degenerative and Dementing Diseases of Aging

National Institutes of Health

Grant: 1F30AG063468-01

The Role of RNA in Tau Aggregation

National Institutes of Health

Grant: 5R01GM045443-31

Stress Granules in Yeast and Mammals

National Institutes of Health

Grant: P50AG023501

National Institutes of Health

Grant: P01AG019724

NIA NIH HHS

Grant: F30 AG063468

NIGMS NIH HHS

Grant: R01 GM045443

NIA NIH HHS

Grant: P01 AG002132

National Institutes of Health

Grant: 5P01AG019724-03

FRONTOTEMPORAL DEMENTIA: GENES, IMAGES, AND EMOTIONS

National Institutes of Health

Grant: 5P01AG002132-32

Degenerative and Dementing Diseases of Aging

National Institutes of Health

Grant: 5P50AG023501-03

DATA MANAGEMENT AND BIOSTATISTICS

National Institutes of Health

Grant: 5F30AG063468-03

The Role of RNA in Tau Aggregation

Howard Hughes Medical Institute

Sherman Fairchild Foundation

Brockman Foundation

Howard Hughes Medical Institute

FWCI

12.14

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

bronzeLicense: Elsevier Non-Commercial

journalhttp://www.cell.com/article/S0896627321001963/pdf

publisherhttp://www.cell.com/article/S0896627321001963/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0896627321001963?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0896627321001963?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.neuron.2021.03.026

Fields of Study

RNA Research and SplicingRNA and protein synthesis mechanismsAlzheimer's disease research and treatments0301 basic medicine0303 health sciences03 medical and health sciencesAlzheimer DiseaseAnimalsCell NucleusCytosolFemaleHEK293 CellsHumansMaleMiceMice, Inbred C57BLProtein BindingProtein TransportRNA SplicingRNA, Small NucleolarRNA-Binding Proteinstau Proteins

MeSH Terms

Alzheimer DiseaseAnimalsCell NucleusCytosolFemaleHumansMaleMice, Inbred C57BLProtein BindingRNA SplicingRNA-Binding Proteinstau ProteinsRNA, Small NucleolarProtein TransportMiceHEK293 Cells

Keywords

RNASpeckle patternCell biologyChemistryBiophysicsNeuroscienceBiologyComputer scienceBiochemistryArtificial intelligenceGeneAlzheimer's diseaseSplicingTauNuclear SpecklesSnrnaRna Binding ProteinsMaptSrrm2Frontemporal DementiaMaleAgingBiological PsychologyNeurodegenerativeInbred C57BLMiceCytosolPsychology2.1 Biological and endogenous factorsAetiologyAlzheimer's Disease Related Dementias (ADRD)RNA-Binding ProteinsFrontotemporal Dementia (FTD)Protein TransportNeurologicalCognitive SciencesFemaleProtein Binding1.1 Normal biological development and functioningRNA Splicingtau ProteinsRare DiseasesUnderpinning researchAlzheimer DiseaseGeneticsAcquired Cognitive ImpairmentAnimalsHumansRNA, Small NucleolarSmall NucleolarCell NucleusNeurology & NeurosurgeryBiomedical and Clinical SciencesNeurosciencesAlzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)Brain DisordersMice, Inbred C57BLHEK293 CellsDementia

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer’s disease

10.6084/m9.figshare.14880602.v1figshare

Additional file 1 of Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer’s disease

10.6084/m9.figshare.14880602figshare

Additional file 6 of The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

10.6084/m9.figshare.26675258figshare

Additional file 6 of The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

10.6084/m9.figshare.26675258.v1figshare

Additional file 3 of The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

10.6084/m9.figshare.26675249.v1figshare

Additional file 3 of The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

10.6084/m9.figshare.26675249figshare

Additional file 5 of The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

10.6084/m9.figshare.26675255.v1figshare

Additional file 4 of The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

10.6084/m9.figshare.26675252.v1figshare

Additional file 4 of The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

10.6084/m9.figshare.26675252figshare

Additional file 5 of The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

10.6084/m9.figshare.26675255figshare

Additional file 1 of The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

10.6084/m9.figshare.26675243figshare

Additional file 2 of The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

10.6084/m9.figshare.26675246.v1figshare

Additional file 1 of The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

10.6084/m9.figshare.26675243.v1figshare

Additional file 2 of The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

10.6084/m9.figshare.26675246figshare

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Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (10)

Funding (17 grants)

Impact

Open Access

Topics

Linked Datasets (14)

Annotations (Europe PMC)

Related Papers (10)