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Expression of gain-of-function CFTR in cystic fibrosis airway cells restores epithelial function better than wild-type or codon-optimized CFTR

Molecular Therapy — Methods & Clinical Development(2023)10.1016/j.omtm.2023.08.006Source: DataRank Database

Expression of gain-of-function CFTR in cystic fibrosis airway cells restores epithelial function better than wild-type or codon-optimized CFTR is a research paper published in Molecular Therapy — Methods & Clinical Development (2023). On theSindex it has a DataRank of 0.562. It has been cited 11 times, with 9 citing works in its 1-hop citation network.

N/A

0.562DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access11 citations · 9 citing works in its network

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Linked data & code

doi

Data availability

Repositories this paper deposited data in (declared in PubMed).

figshare10.6084/m9.figshare.23915565.v1

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (8 grants)Impact (FWCI 1.81)OA: goldTopics (30)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 66%Citation Network 34%

Base Score Contribution

0.373

From this paper's citation signal

Citation Network Contribution

0.189

From 6 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 9 citers.

SP-101, A Novel Adeno-Associated Virus Gene Therapy for the Treatment of Cystic Fibrosis, Mediates Functional Correction of Primary Human Airway Epithelia From Donors with Cystic Fibrosis
Human Gene Therapy202415 citations37 referencesContributes 0.075
Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site-Specific Integration of CFTR and Mutation-Agnostic Disease Rescue
bioRxiv (Cold Spring Harbor Laboratory)20254 citations44 referencesContributes 0.037
Emerging biomarkers for precision diagnosis and personalized treatment of cystic fibrosis
Journal of Rare Diseases202410 citations70 referencesContributes 0.034
F/HN-pseudotyped lentiviral vector efficiently transduces non-human primate airways with no evidence of relevant toxicity
Molecular Therapy Advances20252 citations35 referencesContributes 0.031
Current landscape of cystic fibrosis gene therapy
Frontiers in Pharmacology202423 citations125 referencesContributes 0.025

Authors (9)

Robert Tarran ORCID,Rhianna E. Lee ORCID,Hafssa Anfishi,Stella Prins ORCID,John R. Counsell ORCID

Live enrichment

PubMed:37701179 PMC:PMC10494266 OpenAlex:https://openalex.org/W4385776034

Cystic Fibrosis Foundation

Grant: P30 DK065988

Cystic Fibrosis Trust

Grant: SRC 006

Cystic Fibrosis Trust

Grant: SRC020

Sparks Charity

Grant: 15UCL04

Wellcome Trust

Grant: 210774/Z/18/Z

Cystic Fibrosis Trust

Grant: SRC005

National Institutes of Health

Grant: 3P30DK065988-10S1

Correction Core

National Institutes of Health

FWCI

1.81

Citation Percentile

0.9%

Citation Trend

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttp://www.cell.com/article/S2329050123001201/pdf

publisherhttp://www.cell.com/article/S2329050123001201/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2329050123001201?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2329050123001201?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.omtm.2023.08.006

Fields of Study

Cystic Fibrosis Research AdvancesRNA and protein synthesis mechanismsBacterial Genetics and Biotechnology0303 health sciences03 medical and health sciences

Keywords

Cystic fibrosisCystic fibrosis transmembrane conductance regulatorPhenotypeGeneCell biologyLungWild typeBiologyChemistryCancer researchMolecular biologyGeneticsMedicineInternal medicineGene therapySputumairway epitheliumCftrAirway Surface LiquidCodon OptimisationAnion SecretionQH573-671QH426-470Original ArticleCytology

Sustainable Development Goals

SDG 0: Zero hunger