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Targeted replacement of full-length CFTR in human airway stem cells by CRISPR-Cas9 for pan-mutation correction in the endogenous locus

Molecular Therapy(2021)10.1016/j.ymthe.2021.03.023Source: DataRank Database

Targeted replacement of full-length CFTR in human airway stem cells by CRISPR-Cas9 for pan-mutation correction in the endogenous locus is a research paper published in Molecular Therapy (2021). On theSindex it has a DataRank of 0.637. It has been cited 69 times.

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0.637DataRank · unranked

Scored on demand from live citation data

Open Access69 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (21 grants)OA: hybridTopics (22)IDs (PubMed, PMC)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.637

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

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Authors (20)

Ron Baik ORCID,Lü Chen ORCID,Dawn T. Bravo ORCID,Carlos J. Suarez ORCID,Shayda M. Abazari

Live enrichment

PubMed:33794364 PMC:PMC8753290

NHLBI NIH HHS

Grant: R01 HL151677

NIDDK NIH HHS

Grant: U01 DK085532

NCI NIH HHS

Grant: P30 CA124435

NCI NIH HHS

Grant: U01 CA217851

NIDDK NIH HHS

Grant: U01 DK085527

NIDDK NIH HHS

Grant: U24 DK085532

NIA NIH HHS

Grant: R01 AG056575

NCI NIH HHS

Grant: R35 CA197563

NIDDK NIH HHS

Grant: P30 DK065988

NCI NIH HHS

Grant: U01 CA176299

NIDCR NIH HHS

Grant: K08 DE027730

NIDDK NIH HHS

Grant: K08 DK124684

NIAID NIH HHS

Grant: U19 AI116484

National Institutes of Health

Grant: 5U19AI116484-04

Stanford Cooperative Research Center for Novel, Alternative Model Systems for Enteric Diseases

National Institutes of Health

Grant: 3U01DK085527-09S1

Regulation of actively proliferating and quiescent intestinal stem cells

National Institutes of Health

Grant: 5U01CA217851-05

Organoid-based Discovery of Oncogenic Drivers and Treatment Resistance Mechanisms

National Institutes of Health

Grant: 7K08DE027730-02

Modeling Oral Cancer in Primary Organoid Culture

CIRM

National Institutes of Health

Cancer Prevention and Research Institute of Texas

Cystic Fibrosis Foundation

hybridLicense: cc-by-nc-nd

publisherhttp://www.cell.com/article/S1525001621001520/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1525001621001520?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1525001621001520?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8753290

repositoryhttp://hdl.handle.net/20.500.12613/9086

Fields of Study

0303 health sciences03 medical and health sciences

MeSH Terms

Epithelial CellsStem CellsHumansCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorMutationCRISPR-Cas Systems

Keywords

CFCystic FibrosisCrispr-cas9Cftr CorrectionUniversal Cftr CorrectionAirway Stem Cell TherapyGenome Editing For CfStem CellsMutationCystic Fibrosis Transmembrane Conductance RegulatorHumansEpithelial CellsCRISPR-Cas Systems

Sustainable Development Goals

SDG 3: 3. Good health