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Protospacer modification improves base editing of a canonical splice site variant and recovery of CFTR function in human airway epithelial cells

Molecular Therapy — Nucleic Acids(2023)10.1016/j.omtn.2023.06.020Source: DataRank Database

Protospacer modification improves base editing of a canonical splice site variant and recovery of CFTR function in human airway epithelial cells is a research paper published in Molecular Therapy — Nucleic Acids (2023). On theSindex it has a DataRank of 0. It has been cited 14 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access14 citations

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Linked data & code

gen refsnp

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (9 grants)Impact (FWCI 1.47)OA: goldTopics (28)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

Erin W. Kavanagh ORCID,Gregory A. Newby ORCID,Shakela Mitchell,Alice C. Eastman ORCID,Kathleen C. Paul ORCID

Live enrichment

PubMed:37547293 PMC:PMC10400809 OpenAlex:https://openalex.org/W4382601899

National Institutes of Health

Grant: R35 GM118062

National Institutes of Health

Grant: RM1 HG009490

National Institutes of Health

Grant: U01 AI142756

Cystic Fibrosis Foundation

Grant: CUTTIN20G0

Cystic Fibrosis Foundation

Grant: SHARMA19I0

Helen Hay Whitney Foundation

Howard Hughes Medical Institute

Vertex Pharmaceuticals Inc

Johns Hopkins University

FWCI

1.47

Citation Percentile

0.8%

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.omtn.2023.06.020

publisherhttps://doi.org/10.1016/j.omtn.2023.06.020

publisherhttps://api.elsevier.com/content/article/PII:S2162253123001701?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2162253123001701?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/37547293

Fields of Study

CRISPR and Genetic EngineeringRNA regulation and diseaseRNA and protein synthesis mechanisms

Keywords

MinigeneContext (archaeology)CRISPRRNA splicingCystic fibrosis transmembrane conductance regulatorBiologyCystic fibrosisElectroporationGuide RNAGeneIntronGene isoformRNA editingGenome editingComputational biologyGeneticsRNACFAbeCftr FunctionPrimary Airway Epithelial CellsMt: Rna/Dna EditingCrispr-cas9-mediated Adenine Base EditingCssvCanonical Splice Site Variant

Sustainable Development Goals

SDG 0: Good health and well-being