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N-Substituted-3-alkoxy-derivatives of dextromethorphan are functional NMDA receptor antagonists in vivo: Evidence from an NMDA-induced seizure model in rats

Pharmacology Biochemistry and Behavior(2021)10.1016/j.pbb.2021.173154Source: DataRank Database

N-Substituted-3-alkoxy-derivatives of dextromethorphan are functional NMDA receptor antagonists in vivo: Evidence from an NMDA-induced seizure model in rats is a research paper published in Pharmacology Biochemistry and Behavior (2021). On theSindex it has a DataRank of 0. It has been cited 5 times.

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Open Access5 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 0.30)OA: greenTopics (60)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Rok Cerne ORCID,Amy Hauck Newman ORCID,Sari Izenwasser ORCID,Jodi L. Smith ORCID,Frank C. Tortella

Live enrichment

PubMed:33609599 PMC:PMC9659398 OpenAlex:https://openalex.org/W3130291264

NIMH NIH HHS

Grant: R01 MH096463

NINDS NIH HHS

Grant: R01 NS076517

Intramural NIH HHS

Grant: ZIA DA000389

University of Wisconsin-Milwaukee

FWCI

0.30

Citation Percentile

0.5%

Citation Trend

2022

2023

2024

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9659398

publisherhttps://api.elsevier.com/content/article/PII:S0091305721000538?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0091305721000538?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.pbb.2021.173154

Fields of Study

Pharmacological Receptor Mechanisms and EffectsNeuroscience and Neuropharmacology ResearchNeuropeptides and Animal PhysiologyAlcoholsAnimalsAnticonvulsantsBinding SitesDextromethorphanDextrorphanDisease Models, AnimalExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsInfusions, IntraventricularLigandsMaleN-MethylaspartateRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateReceptors, sigmaSeizuresTreatment OutcomeSigma-1 Receptor

MeSH Terms

Sigma-1 ReceptorAlcoholsAnimalsAnticonvulsantsBinding SitesDextromethorphanDextrorphanDisease Models, AnimalLigandsMaleSeizuresReceptors, N-Methyl-D-AspartateN-MethylaspartateTreatment OutcomeRats, Sprague-DawleyReceptors, sigmaExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsRatsInfusions, Intraventricular

Keywords

DextromethorphanNMDA receptorPharmacologyAnticonvulsantChemistryIn vivoReceptorPsychotomimeticEpilepsyMedicineBiochemistryBiologyNeuroscienceNMDA receptorsSigma ReceptorsDextromethorphan AnalogsNmda Seizures

Sustainable Development Goals

SDG 0: Good health and well-being