Amy Hauck Newman

Also affiliated with National Institute on Drug Abuse, National Health Research Institutes

NeuroscienceBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

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Indexed papers

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 57 papers. Top paper: “Dopamine D3 receptor-based medication development for the treatment of opioid use disorder: Rationale, progress, and challenges”.

Dopamine D3 receptor-based medication development for the treatment of opioid use disorder: Rationale, progress, and challenges

Neuroscience & Biobehavioral Reviews(2020)10.1016/j.neubiorev.2020.04.024

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54 citations

Amy Hauck Newman, Zheng‐Xiong Xi, Ewa Galaj

Neurochemical and behavioral comparisons of contingent and non-contingent methamphetamine exposure following binge or yoked long-access self-administration paradigms

Psychopharmacology(2020)10.1007/s00213-020-05513-z

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25 citations

Caitlin Burzynski, Subramaniam Jayanthi, Bruce Ladenheim, Jean Lud Cadet, Eliot L. Gardner +5 more

(±)VK4‐40, a novel dopamine D3 receptor partial agonist, attenuates cocaine reward and relapse in rodents

British Journal of Pharmacology(2020)10.1111/bph.15244

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19 citations

Yi He, Guo‐Hua Bi, Zhi‐Bing You, Jianjing Cao, Zheng‐Xiong Xi +2 more

Evidence for a Stereoselective Mechanism for Bitopic Activity by Extended-Length Antagonists of the D3 Dopamine Receptor

ACS Chemical Neuroscience(2020)10.1021/acschemneuro.0c00425

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15 citations

Alessandro Bonifazi, Adrian M. Guerrero, Vivek Kumar, R. Benjamin Free, J. Robert Lane +5 more

Design and Synthesis of Fluorescent Methylphenidate Analogues for a FRET‐Based Assay of Synapsin III Binding

ChemMedChem(2020)10.1002/cmdc.202000128

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11 citations

Francesca Longhena, Valentina Straniero, Gaia Faustini, Amy Hauck Newman, Arianna Bellucci +2 more

Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine D3R Bitopic Agonists

ACS Medicinal Chemistry Letters(2020)10.1021/acsmedchemlett.9b00660

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12 citations

Amy Hauck Newman, Alessandro Bonifazi, Francisco O. Battiti

Modafinil and its structural analogs as atypical dopamine uptake inhibitors and potential medications for psychostimulant use disorder

Current Opinion in Pharmacology(2020)10.1016/j.coph.2020.07.007

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33 citations

Melinda Hersey, Briana J. Hempel, Zheng‐Xiong Xi, Amy Hauck Newman, Gianluigi Tanda

Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter

ACS Chemical Neuroscience(2020)10.1021/acschemneuro.0c00397

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24 citations

Carmen Klein Herenbrink, Matthew D. Lycas, Therese Ku, Alessandro Bonifazi, Brian T. DeVree +7 more

Allosterically Linked Binding Sites in Serotonin Transporter Revealed by Single Molecule Force Spectroscopy

Frontiers in Molecular Biosciences(2020)10.3389/fmolb.2020.00099

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7 citations

Walter Sandtner, Joan E. A. Ahiable, Amy Hauck Newman, Michael Freissmuth, Harald H. Sitte +2 more

Cocaine analogue conjugated magnetic nanoparticles for labeling and imaging dopaminergic neurons

Biomaterials Science(2020)10.1039/d0bm00546k

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3 citations

Guanyou Lin, Zachary R. Stephen, Josey E. Vechey, Manjot Singh, Richard A. Revia +4 more

Two Distinct Ligand Binding Sites in Monoamine Transporters Monitored by Nanopharmacological Force Sensing

Biophysical Journal(2020)10.1016/j.bpj.2019.11.3337

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0 citations

Julia Gobl, Marion Holy, Oliver Kudlacek, Walter Sandtner, Thomas Stockner +6 more

Effects of the selective dopamine D 3 receptor antagonist PG01037 on morphine-induced hyperactivity and antinociception in mice

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.04.07.029918

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0 citations

Stephanie L. Foster, Desta M. Pulley, Briana Hempel, Guo-Hua Bi, Zheng-Xiong Xi +4 more

A dominant-negative variant in the dopamine transporter PDZ-binding motif is linked to parkinsonism and neuropsychiatric disease

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.12.336461

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0 citations

Kathrine L. Jensen, Sasha Tolstoy, Natascha V. Arends, Leonie P. Posselt, Aparna Shekar +18 more

New Drugs, Old Targets: Tweaking the Dopamine System to Treat Psychostimulant Use Disorders

The Annual Review of Pharmacology and Toxicology(2021)10.1146/annurev-pharmtox-030220-124205

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58 citations

Therese Ku, Chloe J. Jordan, Alessandro Bonifazi, Zheng‐Xiong Xi, Amy Hauck Newman

Novel Dual-Target μ-Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c00611

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26 citations

Francisco O. Battiti, Julie Sanchez, Saheem A. Zaidi, Eric W. Bow, Mariia Makarova +9 more

Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach

Journal of Chemical Information and Modeling(2021)10.1021/acs.jcim.1c00856

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24 citations

Andrew D. Fant, Jiqing Guo, Andy Guan, Joslyn Jung, Mary Kudaibergenova +9 more

Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor

Biomolecules(2021)10.3390/biom11040570

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23 citations

Bing Xie, Ana Semeano, Alessandro Bonifazi, Francisco O. Battiti, Amy Hauck Newman +3 more

Psychostimulant Use Disorder, an Unmet Therapeutic Goal: Can Modafinil Narrow the Gap?

Frontiers in Neuroscience(2021)10.3389/fnins.2021.656475

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22 citations

Amanda K. Bacon, Lydia G. Bailey, Mark A. Coggiano, Amy Hauck Newman, Lorenzo Leggio +2 more

Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease

JCI Insight(2021)10.1172/jci.insight.151496

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21 citations

Kathrine L. Jensen, Sasha Tolstoy, Natascha V. Arends, Leonie P. Posselt, Aparna Shekar +18 more

Effects of the selective dopamine D3 receptor antagonist PG01037 on morphine-induced hyperactivity and antinociception in mice

Behavioural Brain Research(2021)10.1016/j.bbr.2021.113506

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17 citations

Stephanie L. Foster, Desta M. Pulley, Briana J. Hempel, Guo‐Hua Bi, Zheng‐Xiong Xi +4 more

Scaffold Hybridization Strategy Leads to the Discovery of Dopamine D3 Receptor-Selective or Multitarget Bitopic Ligands Potentially Useful for Central Nervous System Disorders

ACS Chemical Neuroscience(2021)10.1021/acschemneuro.1c00368

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16 citations

Amy Hauck Newman, Thomas M. Keck, Silvia Gervasoni, Giulio Vistoli, Fabio Del Bello +5 more

Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D2/D3 Receptor Bitopic Ligands

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c01353

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18 citations

Comfort A. Boateng, Francisco O. Battiti, Alessandro Bonifazi, Jianjing Cao, Li Chen +6 more

Chiral Cyclic Aliphatic Linkers as Building Blocks for Selective Dopamine D2 or D3 Receptor Agonists

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c01433

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13 citations

Saheem A. Zaidi, Vsevolod Katritch, Amy Hauck Newman, Alessandro Bonifazi, Francisco O. Battiti

Illuminating the norepinephrine transporter: fluorescent probes based on nisoxetine and talopram

RSC Medicinal Chemistry(2021)10.1039/d1md00072a

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12 citations

Andrea Casiraghi, Deborah Rudin, Dino Luethi, Therese Ku, Daryl A. Guthrie +6 more

N-Substituted-3-alkoxy-derivatives of dextromethorphan are functional NMDA receptor antagonists in vivo: Evidence from an NMDA-induced seizure model in rats

Pharmacology Biochemistry and Behavior(2021)10.1016/j.pbb.2021.173154

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5 citations

Rok Cerne, Amy Hauck Newman, Sari Izenwasser, Jodi L. Smith, Frank C. Tortella +1 more

Synaptic-like axo-axonal transmission from striatal cholinergic interneurons onto dopaminergic fibers

Neuron(2022)10.1016/j.neuron.2022.07.011

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112 citations

Samuel G. Brill-Weil, Alex C. Cummins, Renshu Zhang, Gisela Andrea Camacho‐Hernandez, Amy Hauck Newman +4 more

Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity

Cell Reports(2022)10.1016/j.celrep.2022.111431

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36 citations

Aske L. Ejdrup, Andreas T. Sørensen, Nicolai O. Haahr, Søren Jørgensen, Daryl A. Guthrie +7 more

Preferential Gs protein coupling of the galanin Gal1 receptor in the µ-opioid-Gal1 receptor heterotetramer

Pharmacological Research(2022)10.1016/j.phrs.2022.106322

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35 citations

Estefanía Moreno, Nil Casajuana-Martín, Verònica Casadó-Anguera, Ning-Sheng Cai, Gisela Andrea Camacho‐Hernandez +11 more

Current Perspectives on Selective Dopamine D3 Receptor Antagonists/Partial Agonists as Pharmacotherapeutics for Opioid and Psychostimulant Use Disorders

Current topics in behavioral neurosciences(2022)10.1007/7854_2022_347

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33 citations

Zheng‐Xiong Xi, Christian Heidbreder, Amy Hauck Newman

Pharmacological targeting of G protein-coupled receptor heteromers

Pharmacological Research(2022)10.1016/j.phrs.2022.106476

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20 citations

Nil Casajuana-Martín, Michael Coyle, Baruc Campos, Ewa Galaj, Claudia Llinás del Torrent +13 more

The Effects of the Dopamine Transporter Ligands JJC8-088 and JJC8-091 on Cocaine versus Food Choice in Rhesus Monkeys

Journal of Pharmacology and Experimental Therapeutics(2022)10.1124/jpet.122.001363

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13 citations

Jianjing Cao, Jenny Lam, Steven R. Childers, Rana Rais, Linda J. Porrino +3 more

Methylphenidate Analogues as a New Class of Potential Disease-Modifying Agents for Parkinson’s Disease: Evidence from Cell Models and Alpha-Synuclein Transgenic Mice

Pharmaceutics(2022)10.3390/pharmaceutics14081595

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10 citations

Francesca Longhena, Gaia Faustini, Giovanni Ribaudo, Lorenzo Suigo, Gisela Andrea Camacho‐Hernandez +8 more

Illuminating the monoamine transporters: Fluorescently labelled ligands to study dopamine, serotonin and norepinephrine transporters

Basic & Clinical Pharmacology & Toxicology(2022)10.1111/bcpt.13827

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9 citations

Khorshada Jahan, Amy Hauck Newman, Gisela Andrea Camacho‐Hernandez

Fast synaptic-like axo-axonal transmission from striatal cholinergic interneurons onto dopaminergic fibers

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.03.25.485828

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3 citations

Samuel G. Brill-Weil, Alex C. Cummins, Renshu Zhang, Gisela Andrea Camacho‐Hernandez, Amy Hauck Newman +4 more

Dopamine D3/D2 Receptor Ligands Based on Cariprazine for the Treatment of Psychostimulant Use Disorders That May Be Dual Diagnosed with Affective Disorders

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.2c01624

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18 citations

Caleb D. Vogt, Julie Sanchez, Alessandro Bonifazi, Elizabeth Saab, Anver Basha Shaik +7 more

Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c00417

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15 citations

Elizabeth Saab, Julie Sanchez, Antonina L. Nazarova, Saheem A. Zaidi, Khorshada Jahan +5 more

Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c00734

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10 citations

Ashley N. Nilson, Rebekah Placide, Mimi L. Pham, Franziska M. Jakobs, Noelia Boldizsar +30 more

An FSCV Study on the Effects of Targeted Typical and Atypical DAT Inhibition on Dopamine Dynamics in the Nucleus Accumbens Shell of Male and Female Mice

ACS Chemical Neuroscience(2023)10.1021/acschemneuro.3c00354

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8 citations

Andy Y. Chen, Mattingly K. Bartole, Jayati Anand, Amy Hauck Newman, Gianluigi Tanda +1 more

Effects of buprenorphine, methadone, and cariprazine on economic choice between remifentanil and food in squirrel monkeys

Addiction Neuroscience(2023)10.1016/j.addicn.2023.100065

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3 citations

Jacquelin C Hecker, Hector L. Figueroa-Monsanto, Devin P. Effinger, Rodrigo A. Montoro, Hank P. Jedema +5 more

Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c02037

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8 citations

Gisela Andrea Camacho‐Hernandez, Kristine Salomon, Kuo Hao Lee, Therese Ku, Jianjing Cao +11 more

3,4-Methylenedioxypyrovalerone High-Responder Phenotype as a Tool to Evaluate Candidate Medications for Stimulant Use Disorder

Journal of Pharmacology and Experimental Therapeutics(2023)10.1124/jpet.122.001419

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4 citations

Lindsey Peng, Jianjing Cao, Kenner C. Rice, Amy Hauck Newman, Gregory T. Collins +1 more

Disruptive mutations in the serotonin transporter associate serotonin dysfunction with treatment-resistant affective disorder

medRxiv(2023)10.1101/2023.08.29.23294386

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2 citations

Trine N. Jørgensen, Thomas Sparsø, Henrik Berg Rasmussen, Vivek Kumar, Amy Hauck Newman +5 more

Presynaptic and Postsynaptic Mesolimbic Dopamine D3 Receptors Play Distinct Roles in Cocaine Versus Opioid Reward in Mice

Biological Psychiatry(2024)10.1016/j.biopsych.2024.05.020

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13 citations

Miriam E. Bocarsly, Ewa Galaj, Briana J. Hempel, Catherine E. Teresi, Marlisa Shaw +9 more

Involvement of dopamine D3 receptor in impulsive choice decision-making in male rats

Neuropharmacology(2024)10.1016/j.neuropharm.2024.110051

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10 citations

Zilu Ma, Emma Hans, Ying Duan, Guo-Hua Bi, Yurim Chae +6 more

Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia

Diabetes(2024)10.2337/db24-0175

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7 citations

Michael P. Ellenberger, Zachary J. Farino, Despoina Aslanoglou, Rana Rais, Sandra Pereira +10 more

Linkers in Bitopic Agonists Shape Bias Profile among Transducers for the Dopamine D2 and D3 Receptors

ACS Pharmacology & Translational Science(2024)10.1021/acsptsci.4c00119

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7 citations

Rian Garland, Alessandro Bonifazi, Kuo Hao Lee, John Famiglietti, Wenqi Zhang +6 more

In vitro safety evaluation of dopamine D3R antagonist, R-VK4-116, as a potential medication for the treatment of opioid use disorder

PLoS ONE(2024)10.1371/journal.pone.0315569

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3 citations

Amy Hauck Newman, Pramod Terse, Rahul Nandre

Contrasting the reinforcing effects of the novel dopamine transport inhibitors JJC8-088 and JJC8-091 in monkeys: Potential translation to medication assisted treatment

Journal of Pharmacology and Experimental Therapeutics(2024)10.1124/jpet.124.002356

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6 citations

Omeed Rahimi, Bernard Johnson, Jianjing Cao, Amy Hauck Newman, Michael A. Nader +1 more

Development of a Fluorescently Labeled Ligand for Rapid Detection of DAT in Human and Mouse Peripheral Blood Monocytes

JACS Au(2024)10.1021/jacsau.3c00719

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6 citations

Adithya Gopinath, Amarachi V. Okorom, Habibeh Khoshbouei, Amy Hauck Newman, Gisela Andrea Camacho‐Hernandez

Series of (([1,1′-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity

ACS Pharmacology & Translational Science(2024)10.1021/acsptsci.3c00322

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5 citations

Jianjing Cao, Sung Joon Won, Jiqing Guo, Gisela Andrea Camacho‐Hernandez, Amarachi V. Okorom +7 more

Monoamine transporter ubiquitination and inward-open conformation synergistically maximize transporter endocytosis

Science Advances(2024)10.1126/sciadv.adq9793

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3 citations

Tarique Rajasaheb Bagalkot, Mary Hongying Cheng, Daryl A. Guthrie, Amy Hauck Newman, Simon C. Watkins +2 more

The Structural Basis of the Activity Cliff in Modafinil-Based Dopamine Transporter Inhibitors

Biomolecules(2024)10.3390/biom14060713

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1 citations

Gisela Andrea Camacho‐Hernandez, Amy Hauck Newman, Lei Shi, Kuo-Hao Lee

Development of novel tools for dissection of central versus peripheral dopamine D 2 -like receptor signaling in dysglycemia

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.21.581451

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0 citations

Michael P. Ellenberger, Zachary J. Farino, Despoina Aslanoglou, Rana Rais, Sandra Pereira +10 more

A subtle modification of modafinil-based DAT inhibitors changes conformational preference

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.03.06.583808

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0 citations

Gisela Andrea Camacho‐Hernandez, Amy Hauck Newman, Lei Shi, Kuo Hao Lee

ESG‐1‐60 and ESG‐1‐61: Novel dopamine D3 receptor‐preferring partial agonists/antagonists that inhibit cocaine taking and seeking in rodents

British Journal of Pharmacology(2025)10.1111/bph.70021

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4 citations

Bradley M. Keegan, Hannah Alton, Guo‐Hua Bi, Emily Linz, Caleb D. Vogt +5 more

Development of a HiBiT Peptide-Based NanoBRET Ligand Binding Assay for Galanin Receptor 1 in Live Cells

ACS Chemical Biology(2025)10.1021/acschembio.5c00166

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1 citations

Harrison C. Daly, Tae Gyun Yang, Joshua R. Born, Gisela Andrea Camacho‐Hernandez, Mingyang Yuan +11 more

Effects of buprenorphine, methadone, and cariprazine on economic choice between remifentanil and food in squirrel monkeys

UNC Libraries(2025)10.17615/nxzh-xr34

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0 citations

Charles W. Bradberry, Rodrigo A. Montoro, Hank P. Jedema, Caleb D. Vogt, Héctor Figueroa +5 more