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Aldehyde dehydrogenase-2 activation decreases acetaminophen hepatotoxicity by prevention of mitochondrial depolarization

Toxicology and Applied Pharmacology(2020)10.1016/j.taap.2020.114982Source: DataRank Database

Aldehyde dehydrogenase-2 activation decreases acetaminophen hepatotoxicity by prevention of mitochondrial depolarization is a research paper published in Toxicology and Applied Pharmacology (2020). On theSindex it has a DataRank of 0. It has been cited 23 times.

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Open Access23 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 3.13)OA: greenTopics (55)IDs (PubMed, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Jiangting Hu ORCID,Kenji Takemoto ORCID,Nga Nguyen ORCID,Hartmut Jaeschke ORCID,John J. Lemasters ORCID

Live enrichment

PubMed:32240663 OpenAlex:https://openalex.org/W3014331104

National Institutes of Health

Grant: 1S10OD018113-01A1

Confocal/Multiphoton Microscope Upgrade

National Institutes of Health

Grant: 5P30CA138313-09

Medical University of South Carolina - Cancer Center Support Grant

National Institutes of Health

Grant: 5T32DK083262-09

Training in Bioenergetics, Oxidative Stress and Metabolic Syndrome

National Institutes of Health

Grant: 5F31DK108570-02

Aldehyde Dehydrogenase-2 as a Drug Target for Cholestatic Liver Fibrosis

FWCI

3.13

Citation Percentile

0.9%

Citation Trend

2020

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2022

2023

2024

2025

2026

greenLicense: Elsevier TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7716617

publisherhttps://api.elsevier.com/content/article/PII:S0041008X2030106X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0041008X2030106X?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.taap.2020.114982

Fields of Study

Drug-Induced Hepatotoxicity and ProtectionLiver Disease and TransplantationLiver Disease Diagnosis and Treatment0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Aldehyde Dehydrogenase, MitochondrialAcetaminophenAlanine TransaminaseAnimalsAspartate AminotransferasesBenzamidesEnzyme ActivationLiverMaleMice, Inbred C57BLMitochondria, LiverAnalgesics, Non-NarcoticMicroscopy, Fluorescence, MultiphotonMiceBenzodioxolesChemical and Drug Induced Liver Injury

Keywords

AcetaminophenChemistryALDH2Lipid peroxidationLiver injuryMitochondrionAldehyde dehydrogenaseMitochondrial permeability transition poreOxidative stressBiochemistryPharmacologyEndocrinologyInternal medicineProgrammed cell deathBiologyApoptosisMedicineEnzymeMaleAldehyde Dehydrogenase, MitochondrialAlanine TransaminaseMitochondria, LiverAnalgesics, Non-NarcoticEnzyme ActivationMice, Inbred C57BLMiceMicroscopy, Fluorescence, MultiphotonLiverBenzamidesAnimalsAspartate AminotransferasesBenzodioxolesChemical and Drug Induced Liver Injury

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being