Hartmut Jaeschke

Pharmacology, Toxicology and PharmaceuticsMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

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Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 40 papers. Top paper: “Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity”.

Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity

Food and Chemical Toxicology(2020)10.1016/j.fct.2020.111240

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129 citations

Anup Ramachandran, Hartmut Jaeschke

A mitochondrial journey through acetaminophen hepatotoxicity

Food and Chemical Toxicology(2020)10.1016/j.fct.2020.111282

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89 citations

Hartmut Jaeschke, Anup Ramachandran

4-methylpyrazole protects against acetaminophen-induced acute kidney injury

Toxicology and Applied Pharmacology(2020)10.1016/j.taap.2020.115317

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70 citations

Anup Ramachandran, Hi̇lmi̇ Orhan, Steven C. Curry, Barry H. Rumack, Hartmut Jaeschke +1 more

Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice

Toxicology Letters(2020)10.1016/j.toxlet.2020.12.005

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68 citations

Kuo Du, Jephte Y. Akakpo, David S. Umbaugh, Hartmut Jaeschke, Anup Ramachandran +1 more

Late Protective Effect of Netrin-1 in the Murine Acetaminophen Hepatotoxicity Model

Toxicological Sciences(2020)10.1093/toxsci/kfaa041

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21 citations

Benjamin L. Woolbright, Hartmut Jaeschke, Anup Ramachandran, Luqi Duan

The role of oxidant stress in acetaminophen-induced liver injury

Current Opinion in Toxicology(2020)10.1016/j.cotox.2020.03.003

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26 citations

Anup Ramachandran, Hartmut Jaeschke

Aldehyde dehydrogenase-2 activation decreases acetaminophen hepatotoxicity by prevention of mitochondrial depolarization

Toxicology and Applied Pharmacology(2020)10.1016/j.taap.2020.114982

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23 citations

Jiangting Hu, Kenji Takemoto, Nga Nguyen, Hartmut Jaeschke, John J. Lemasters +2 more

Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice

UNC Libraries(2020)10.17615/9qjf-tz56

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0 citations

James P. Luyendyk, Nigel Mackman, Kevin C. Flanagan, Glenn H. Cantor, Hartmut Jaeschke +2 more

Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

Acta Pharmaceutica Sinica B(2021)10.1016/j.apsb.2021.09.023

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143 citations

Olamide B. Adelusi, Jephte Y. Akakpo, Nga Nguyen, Giselle Sánchez-Guerrero, David S. Umbaugh +3 more

Mitochondrial Membrane Potential Drives Early Change in Mitochondrial Morphology After Acetaminophen Exposure

Toxicological Sciences(2021)10.1093/toxsci/kfaa188

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51 citations

Nga Nguyen, Hartmut Jaeschke, Anup Ramachandran, David S. Umbaugh

Spatial Reconstruction of the Early Hepatic Transcriptomic Landscape After an Acetaminophen Overdose Using Single-Cell RNA-Sequencing

Toxicological Sciences(2021)10.1093/toxsci/kfab052

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40 citations

Anup Ramachandran, Hartmut Jaeschke, David S. Umbaugh

Mitochondrial Dynamics in Drug-Induced Liver Injury

Livers(2021)10.3390/livers1030010

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29 citations

David S. Umbaugh, Hartmut Jaeschke, Anup Ramachandran

Biomarkers of mitotoxicity after acute liver injury: further insights into the interpretation of glutamate dehydrogenase

Journal of Clinical and Translational Research(2021)10.18053/jctres.07.202101.005

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30 citations

Hartmut Jaeschke, Mitchell R. McGill

Fructose Protects Against Acetaminophen‐Induced Hepatotoxicity Mainly by Activating the Carbohydrate‐Response Element‐Binding Protein α–Fibroblast Growth Factor 21 Axis in Mice

Hepatology Communications(2021)10.1002/hep4.1683

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8 citations

Sujuan Wang, Erin Ospina, Omar Shabandri, Daniel Lank, Jephte Y. Akakpo +8 more

Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice

Liver Research(2021)10.1016/j.livres.2021.03.001

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9 citations

Hong‐Min Ni, Jennifer M. McCracken, Jephte Y. Akakpo, Sam Fulte, Tara McKeen +4 more

Targeting the sterile inflammatory response during acetaminophen hepatotoxicity with natural products

Toxicology Letters(2021)10.1016/j.toxlet.2021.11.006

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5 citations

Anup Ramachandran, Hartmut Jaeschke

Regulation of Liver Regeneration by hepatocyte O-GlcNAcylation in mice

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.10.14.464401

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5 citations

Steven R. McGreal, David S. Umbaugh, Wendena S. Parkes, Manasi Kotulkar, Sarah Abernathy +9 more

Dual role of p62/SQSTM1 in acetaminophen‐induced early acute injury and late recovery in mice

The FASEB Journal(2021)10.1096/fasebj.2021.35.s1.02482

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0 citations

Hong‐Min Ni, Hartmut Jaeschke, Wen‐Xing Ding, Hui Qian

Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways

Toxicological Sciences(2022)10.1093/toxsci/kfac015

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37 citations

Stefanie Kennon‐McGill, Stephanie D. Byrum, Samuel G. Mackintosh, Hartmut Jaeschke, D. Keith Williams +5 more

Regulation of Liver Regeneration by Hepatocyte O-GlcNAcylation in Mice

Cellular and Molecular Gastroenterology and Hepatology(2022)10.1016/j.jcmgh.2022.01.014

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26 citations

Steven R. McGreal, David S. Umbaugh, Wendena S. Parkes, Manasi Kotulkar, Sarah Abernathy +9 more

Desorption Electrospray Ionization Mass Spectrometry Imaging Allows Spatial Localization of Changes in Acetaminophen Metabolism in the Liver after Intervention with 4-Methylpyrazole

Journal of the American Society for Mass Spectrometry(2022)10.1021/jasms.2c00202

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24 citations

Matthew W. Jaeschke, Yasaman Etemadi, Antonio Artigues, Scott Toerber, Hernando J. Olivos +5 more

Recovered Hepatocytes Promote Macrophage Apoptosis Through CXCR4 After Acetaminophen-Induced Liver Injury in Mice

Toxicological Sciences(2022)10.1093/toxsci/kfac057

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15 citations

David S. Umbaugh, Eileen L Huang, Olamide B. Adelusi, Giselle Sánchez-Guerrero, Anup Ramachandran +2 more

Platanosides, a Potential Botanical Drug Combination, Decrease Liver Injury Caused by Acetaminophen Overdose in Mice

Journal of Natural Products(2022)10.1021/acs.jnatprod.2c00324

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11 citations

Nga Nguyen, Hartmut Jaeschke, John J. Lemasters, Xiaojuan Wang, Yeun‐Mun Choo +3 more

Acetaminophen Hepatotoxicity: Not as Simple as One Might Think! Introductory Comments on the Special Issue—Recent Advances in Acetaminophen Hepatotoxicity

Livers(2022)10.3390/livers2030008

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5 citations

Hartmut Jaeschke

A non-human primate model of acute liver failure suitable for testing liver support systems

Frontiers in Medicine(2022)10.3389/fmed.2022.964448

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2 citations

Alina Ostrowska, Adam C. Olson, Mubina Quader, Melvin Deutsch, Norma J. Arbujas-Silva +13 more

High-throughput screening of novel TFEB agonists in protecting against acetaminophen-induced liver injury in mice

Acta Pharmaceutica Sinica B(2023)10.1016/j.apsb.2023.10.017

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27 citations

Mengwei Niu, Shaogui Wang, Xiaowen Ma, Xiao Yang, Hua Sun +10 more

Lack of mitochondrial Cyp2E1 drives acetaminophen-induced ER stress-mediated apoptosis in mouse and human kidneys: Inhibition by 4-methylpyrazole but not N-acetylcysteine

Toxicology(2023)10.1016/j.tox.2023.153692

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27 citations

Anup Ramachandran, Barry H. Rumack, Darren P. Wallace, Hartmut Jaeschke, Jephte Y. Akakpo

The chemokine CXCL14 is a novel early prognostic biomarker for poor outcome in acetaminophen-induced acute liver failure

Hepatology(2023)10.1097/hep.0000000000000665

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24 citations

Nga Nguyen, Steven C. Curry, Jody A. Rule, William M. Lee, Anup Ramachandran +3 more

Nrf2 as a therapeutic target in acetaminophen hepatotoxicity: A case study with sulforaphane

Journal of Biochemical and Molecular Toxicology(2023)10.1002/jbt.23505

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19 citations

Jephte Y. Akakpo, Anup Ramachandran, Hartmut Jaeschke, Yasaman Etemadi

The mitochondrial calcium uniporter mediates mitochondrial Fe2+ uptake and hepatotoxicity after acetaminophen

Toxicology and Applied Pharmacology(2023)10.1016/j.taap.2023.116722

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15 citations

Anna‐Liisa Nieminen, James L. Weemhoff, Hartmut Jaeschke, Laura G. Murphy, Judith Dent +2 more

Hepatocyte-specific deletion of small heterodimer partner protects mice against acetaminophen-induced hepatotoxicity via activation of Nrf2

Toxicological Sciences(2023)10.1093/toxsci/kfad104

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3 citations

Nancy Magee, Jephte Y. Akakpo, Forkan Ahamed, Natalie Eppler, Elizabeth Jones +8 more

Translocation of Adenosine A2B Receptor to Mitochondria Influences Cytochrome P450 2E1 Activity after Acetaminophen Overdose

Livers(2023)10.3390/livers4010002

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0 citations

David S. Umbaugh, Abhay A. Ramachandran, Antonio Artigues, Hartmut Jaeschke, Anup Ramachandran +1 more

Central Mechanisms of Acetaminophen Hepatotoxicity: Mitochondrial Dysfunction by Protein Adducts and Oxidant Stress

Drug Metabolism and Disposition(2024)10.1124/dmd.123.001279

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44 citations

Anup Ramachandran, Hartmut Jaeschke

The p21+ perinecrotic hepatocytes produce the chemokine CXCL14 after a severe acetaminophen overdose promoting hepatocyte injury and delaying regeneration

Toxicology(2024)10.1016/j.tox.2024.153804

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26 citations

Nga Nguyen, Sawyer Smith, Anup Ramachandran, Hartmut Jaeschke, David S. Umbaugh

Effect of ferroptosis inhibitors in a murine model of acetaminophen‐induced liver injury

Journal of Biochemical and Molecular Toxicology(2024)10.1002/jbt.23791

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16 citations

Yasaman Etemadi, Jephte Y. Akakpo, Anup Ramachandran, Hartmut Jaeschke, Olamide B. Adelusi

Biomarker discovery in acetaminophen hepatotoxicity: leveraging single-cell transcriptomics and mechanistic insight

Expert Review of Clinical Pharmacology(2024)10.1080/17512433.2024.2306219

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8 citations

Hartmut Jaeschke, David S. Umbaugh

Hepatocyte miR-21-5p-deficiency alleviates APAP-induced liver injury by inducing PPARγ and autophagy

Toxicological Sciences(2024)10.1093/toxsci/kfad132

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6 citations

Fang Yan, Yulan Zhao, Hartmut Jaeschke, Fang Li, Lifang Zhao +3 more

Mixed lineage kinase domain-like protein deficiency exacerbates early injury in a mouse model of acetaminophen hepatotoxicity

Toxicological Sciences(2025)10.1093/toxsci/kfaf022

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1 citations

David S. Umbaugh, Sawyer Smith, Jephte Y. Akakpo, Hartmut Jaeschke, Anup Ramachandran +1 more

The endothelial growth factor Angiopoietin-2 is an accurate prognostic biomarker in patients with acetaminophen-induced acute liver failure

medRxiv(2025)10.1101/2025.02.19.25322567

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1 citations

Nga Nguyen, Steven C. Curry, Jody A. Rule, William M. Lee, Anup Ramachandran +3 more

The endothelial growth factor angiopoietin-2 is an accurate prognostic biomarker in patients with acetaminophen-induced acute liver failure

Toxicological Sciences(2025)10.1093/toxsci/kfaf130

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0 citations

Nga Nguyen, Steven C. Curry, Jody A. Rule, William M. Lee, Anup Ramachandran +15 more