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Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases

Trends in Biochemical Sciences(2020)10.1016/j.tibs.2020.03.008Source: DataRank Database

Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases is a research paper published in Trends in Biochemical Sciences (2020). On theSindex it has a DataRank of 4.2. It has been cited 196 times, with 172 citing works in its 1-hop citation network.

N/A

4.2DataRank · unranked

Scored on demand from live citation data

Open Access196 citations · 172 citing works in its network

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Linked data & code

nct doi

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (18 grants)Impact (FWCI 13.62)OA: greenTopics (41)Linked Datasets (2)DataCite Reuse (2)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 19%Citation Network 81%

Base Score Contribution

0.792

From this paper's citation signal

Citation Network Contribution

3.4

From 138 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 172 citers.

Clinical impact of pembrolizumab combined with chemotherapy in elderly patients with advanced non-small-cell lung cancer
Lung Cancer202160 citations36 referencesContributes 0.114
Identification of GL-V9 as a novel senolytic agent against senescent breast cancer cells
Life Sciences202147 citations38 referencesContributes 0.102
Mitochondrial Membrane Disrupting Molecules for Selective Killing of Senescent Cells
ChemBioChem202113 citations26 referencesContributes 0.102
Efficacy and Safety of Programmed Death-Ligand 1 Inhibitor Plus Platinum-Etoposide Chemotherapy in Patients With Extensive-Stage SCLC: A Prospective Observational Study
JTO Clinical and Research Reports202210 citations26 referencesContributes 0.092
Elevated skin senescence in young mice causes delayed wound healing
GeroScience202251 citations43 referencesContributes 0.092

Authors (5)

Eric W.‐F. Lam ORCID,Tamar Tchkonia ORCID,James L. Kirkland ORCID,Yu Sun ORCID,Shuling Song

Live enrichment

PubMed:32531228 PMC:PMC7649645 OpenAlex:https://openalex.org/W3014969606

National Institutes of Health

Grant: P01 AG062413

National Institutes of Health

Grant: R37-AG013925

Cancer Research UK

Grant: A12011

National Key Research and Development Program of China Stem Cell and Translational Research

Grant: 2016YFC1302400

Breast Cancer Now

Grant: 2012MayPR070

Breast Cancer Now

Grant: 2012NovPhD016

U.S. Department of Defense

Grant: PC111703

National Natural Science Foundation of China

Grant: 31871380

National Natural Science Foundation of China

Grant: 81472709

National Natural Science Foundation of China

Grant: 31671425

Medical Research Council

Grant: MR/N012097/1

NIA NIH HHS

Grant: R37 AG013925

National Institutes of Health

Grant: 3P01AG062413-02S1

Targeting Cellular Senescence to Extend Healthspan

National Institutes of Health

Grant: 3R37AG013925-16S1

Effect of Aging on Preadipocyte Differentiation

National Institute for Health Research (NIHR)

Noaber Foundation

National Key Research and Development Program of China

Mayo Clinic

FWCI

13.62

Citation Percentile

1.0%

Influential Citations

Citation Trend

2020

2021

2022

2023

2024

2025

2026

greenLicense: Elsevier TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7649645

GREENhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649645

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7649645

publisherhttps://api.elsevier.com/content/article/PII:S0968000420300852?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0968000420300852?httpAccept=text/plain

Fields of Study

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsMedicineBiology0301 basic medicine0303 health sciences03 medical and health sciencesCellular SenescenceHumansNeoplasmsNeurodegenerative DiseasesPhenotype

MeSH Terms

HumansNeoplasmsPhenotypeCellular SenescenceNeurodegenerative Diseases

Keywords

Cellular AgingAgeingBiologyCell biologyComputational biologyTelomereBiochemistryGeneticsDNACellular senescenceSASPClinical TrialsGeroscienceSenolytics610Neurodegenerative Diseases06 Biological SciencesPhenotypeNeoplasms616Humans03 Chemical Sciences11 Medical and Health SciencesDevelopmental Biology

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of Trends in the incidence and survival of cancer in individuals aged 55 years and older in the United States, 1975–2019

10.6084/m9.figshare.24940493.v1figshare

Additional file 1 of Trends in the incidence and survival of cancer in individuals aged 55 years and older in the United States, 1975–2019

10.6084/m9.figshare.24940493figshare