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Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer’s Disease

Cell Reports Medicine(2020)10.1016/j.xcrm.2020.100138Source: DataRank Database

Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer’s Disease is a research paper published in Cell Reports Medicine (2020). On theSindex it has a DataRank of 3.9. It has been cited 210 times, with 169 citing works in its 1-hop citation network.

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3.9DataRank · unranked

Scored on demand from live citation data

Open Access210 citations · 169 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (37 grants)OA: goldTopics (50)Linked Datasets (14)DataCite Reuse (14)IDs (PubMed, PMC)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 20%Citation Network 80%

Base Score Contribution

0.803

From this paper's citation signal

Citation Network Contribution

3.1

From 144 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 169 citers.

Melatonin improves cholestatic liver disease via the gut‐liver axis
Journal of Pineal Research202323 citations35 referencesContributes 0.091
Bile acid profile associated with CSF and PET biomarkers in Alzheimer’s disease
Aging Clinical and Experimental Research202432 citations41 referencesContributes 0.085
Gut Microbiota-Mediated Elevated Production of Secondary Bile Acids in Chronic Unpredictable Mild Stress
Frontiers in Pharmacology202246 citations52 referencesContributes 0.074
In vitro human colonic fermentation of coffee arabinogalactan and melanoidin-rich fractions
International Journal of Biological Macromolecules202416 citations46 referencesContributes 0.062
Liver Bile Acid Changes in Mouse Models of Alzheimer’s Disease
International Journal of Molecular Sciences202138 citations62 referencesContributes 0.059

Authors (49)

Cory C. Funk ORCID,Jingwen Yan ORCID,James T. Yurkovich ORCID,Alexandra Kueider‐Paisley ORCID,Kwangsik Nho ORCID

Live enrichment

PubMed:33294859 PMC:PMC7691449

NIA NIH HHS

Grant: P30 AG010133

National Institute on Aging

Grant: P30AG10161

NIA NIH HHS

Grant: R01 AG046171

National Institute on Aging

Grant: U01AG46152

Qatar National Research Fund

Grant: NPRP8-061-3-011

NIA NIH HHS

Grant: RF1 AG057452

National Institute on Aging

Grant: RF1 AG058942

Biotechnology and Biological Sciences Research Council

Grant: BB/N015932/1

Imaging cholesterol metabolic flux and transport underlying brain function

Qatar National Research Fund

Grant: NLM R01 LM012535

NIA NIH HHS

Grant: R01 AG015819

NIA NIH HHS

Grant: R01 AG051752

National Institute on Aging

Grant: R01AG17917

Biotechnology and Biological Sciences Research Council

Grant: BB/I001735/1

An Integrated platform for Quantitative Sterolomics: From Oxysterols to Bile Acids and Steroids

NIA NIH HHS

Grant: R01 AG019771

NLM NIH HHS

Grant: R01 LM012535

NIA NIH HHS

Grant: R03 AG054936

NIA NIH HHS

Grant: U01 AG046152

NIA NIH HHS

Grant: RF1 AG051550

NIA NIH HHS

Grant: P30 AG010161

NIA NIH HHS

Grant: R01 AG017917

National Institute on Aging

Grant: R01 AG057452

NCI NIH HHS

Grant: R01 CA129769

National Institute on Aging

Grant: R01AG15819

National Institute on Aging

Grant: RF1 AG0151550

National Institutes of Health

Grant: 1R01LM012535-01

Integrating Neuroimaging, Multi-omics, and Clinical Data in Complex Disease

National Institutes of Health

Grant: 5R01AG046171-03

Metabolic Networks and Pathways in Alzheimer's Disease

National Institutes of Health

Grant: 5R01CA129769-10

Older Breast Cancer Patients: Risk For Cognitive Decline

National Institutes of Health

Grant: 1P30AG010161-01

SHORT-TERM STABILITY OF CLINICAL TESTS

National Institutes of Health

Grant: 1RF1AG057452-01

Metabolic Network Analysis of Biochemical Trajectories in Alzheimer's Disease

National Institutes of Health

Grant: 5R01AG017917-20

Epidemiologic Study of Neural Reserve and Neurobiology of Aging

National Institutes of Health

Grant: 5R03AG054936-02

Neurogenesis in Adult Brain: Gene Networks and Alzheimer’s Disease

National Institutes of Health

Grant: 7U01AG046152-05

Pathway discovery, validation and compound identification for Alzheimer's disease

National Institutes of Health

Grant: 1RF1AG058942-01

Gut Liver Brain Biochemical Axis in Alzheimer's Disease

National Institutes of Health

Grant: 2R01AG019771-06

Memory Circuitry in MCI and Early Alzheimers Disease

National Institutes of Health

Grant: 5R01AG015819-07

Risk Factors, Pathology, and Clinical Expressions of AD

National Institutes of Health

Grant: 5P30AG010133-08

CORE-- EDUCATION AND INFORMATION TRANSFER

Engineering and Physical Sciences Research Council

goldLicense: cc-by-nc-nd

publisherhttp://www.cell.com/article/S2666379120301828/pdf

repositoryhttps://cronfa.swan.ac.uk/Record/cronfa55544

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7691449

repositoryhttps://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=60721

Europe_PMChttps://europepmc.org/articles/PMC7691449

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

BrainHumansAlzheimer DiseaseBile Acids and SaltsCholesterolLipogenesisLipid MetabolismMetabolic Networks and PathwaysMetabolomicsTranscriptomeCognitive Dysfunction

Keywords

Alzheimer's diseaseBile acidsMetabolomicsCholesterol MetabolismTranscriptomicsGenome-scale Metabolic ModelsTranscriptional Regulatory Networks570Aging610NeurodegenerativeArticleBile Acids and SaltsAlzheimer DiseaseAcquired Cognitive ImpairmentGenetics2.1 Biological and endogenous factorsHumansCognitive DysfunctionAetiologyNutritionLiver DiseaseLipogenesisAlzheimer's Disease ; Bile Acids ; Cholesterol Metabolism ; Genome-scale Metabolic Models ; Metabolomics ; Transcriptional Regulatory Networks ; TranscriptomicsAlzheimer’s Disease Metabolomics ConsortiumNeurosciencesAlzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)BrainLipid MetabolismBrain DisordersCholesterolNeurologicalDementiaDigestive DiseasesTranscriptomeMetabolic Networks and Pathways

Sustainable Development Goals

SDG 3: 3. Good health

Additional file 10 of Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease

10.6084/m9.figshare.16575423.v1figshare

Additional file 10 of Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease

10.6084/m9.figshare.16575423figshare

Additional file 11 of Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease

10.6084/m9.figshare.16575432.v1figshare

Additional file 11 of Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease

10.6084/m9.figshare.16575432figshare

Additional file 1 of Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease

10.6084/m9.figshare.16575435.v1figshare

Additional file 1 of Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease

10.6084/m9.figshare.16575435figshare

Additional file 2 of Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease

10.6084/m9.figshare.16575438.v1figshare

Additional file 2 of Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease

10.6084/m9.figshare.16575438figshare

Additional file 3 of Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease

10.6084/m9.figshare.16575441.v1figshare

Additional file 3 of Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease

10.6084/m9.figshare.16575441figshare

Additional file 9 of Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease

10.6084/m9.figshare.16575459.v1figshare

Additional file 9 of Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease

10.6084/m9.figshare.16575459figshare

Additional file 1 of Linear programming based gene expression model (LPM-GEM) predicts the carbon source for Bacillus subtilis

10.6084/m9.figshare.20056237.v1figshare

Additional file 1 of Linear programming based gene expression model (LPM-GEM) predicts the carbon source for Bacillus subtilis

10.6084/m9.figshare.20056237figshare

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Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer’s Disease

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (49)

Funding (37 grants)

Open Access

Topics

Linked Datasets (14)

Annotations (Europe PMC)

Related Papers (10)