Pilot corpus: NIH-funded biomedical datasets. Any DOI can be scored on demand — network effects sharpen as coverage grows.

A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq

Molecular Therapy(2020)10.1016/j.ymthe.2020.07.023Source: DataRank Database

A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq is a research paper published in Molecular Therapy (2020). On theSindex it has a DataRank of 3.3. It has been cited 111 times, with 93 citing works in its 1-hop citation network.

N/A

3.3DataRank · unranked

Scored on demand from live citation data

Open Access111 citations · 93 citing works in its network

Download PDF

Cite:

Linked data & code

doi

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 4.71)OA: hybridTopics (38)Linked Datasets (6)DataCite Reuse (6)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

FAIR checklist signals are shown for context only and do not affect DataRank scoring.

Run a calibrated FAIR evaluation for this paper →

We only score data papers we can read in full — never from an abstract alone.

DataRank Breakdown

Base Score 22%Citation Network 78%

Base Score Contribution

0.708

From this paper's citation signal

Citation Network Contribution

2.6

From 77 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 93 citers.

Single-cell transcriptome analysis of CAR T-cell products reveals subpopulations, stimulation, and exhaustion signatures
OncoImmunology202136 citations30 referencesContributes 0.120
A long-acting interleukin-7, rhIL-7-hyFc, enhances CAR T cell expansion, persistence, and anti-tumor activity
Nature Communications202297 citations39 referencesContributes 0.118
Blockade or Deletion of IFNγ Reduces Macrophage Activation without Compromising CAR T-cell Function in Hematologic Malignancies
Blood Cancer Discovery2021137 citations44 referencesContributes 0.112
Protocol for the simultaneous activation and lentiviral transduction of primary human T cells with artificial T cell receptors
STAR Protocols20253 citations14 referencesContributes 0.099
Novel CS1 CAR-T Cells and Bispecific CS1-BCMA CAR-T Cells Effectively Target Multiple Myeloma
Biomedicines202128 citations37 referencesContributes 0.091

Authors (22)

Rebecca C. Larson ORCID,Nemanja Despot Marjanovic,Kirk Gosik ORCID,Ana P. Castano,Selena J. Lorrey

Live enrichment

PubMed:32755564 PMC:PMC7704462 OpenAlex:https://openalex.org/W3044609915

NCI NIH HHS

Grant: R01 CA238268

NCI NIH HHS

Grant: K08 CA166039

NIAID NIH HHS

Grant: T32 AI007529

NIAID NIH HHS

Grant: T32 AI118692

Gabrielle’s Angel Foundation for Cancer Research

National Institutes of Health

FWCI

4.71

Citation Percentile

1.0%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by-nc-nd

journalhttp://www.cell.com/article/S1525001620303749/pdf

publisherhttp://www.cell.com/article/S1525001620303749/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1525001620303749?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1525001620303749?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.ymthe.2020.07.023

Fields of Study

CAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell Immunology

MeSH Terms

Protein DomainsReceptors, Chimeric AntigenRNA-SeqHumansT-LymphocytesTransduction, GeneticSignal TransductionK562 CellsRNA, Small Cytoplasmic4-1BB LigandHEK293 CellsSingle-Cell AnalysisTranscriptomeCell Engineering

Keywords

CD28BiologyCD3T cellT-cell receptorCD19Chimeric antigen receptorCD8Cell biologyCytotoxic T cellMolecular biologyAntigenImmunologyGeneticsImmune systemIn vitroT cell activationTranscriptional ProfilingAdoptive Cellular TherapySingle-cell Rna SequencingCar T cells

Sustainable Development Goals

SDG 0: Good health and well-being

Additional file 3 of The 4-1BBζ costimulatory domain in chimeric antigen receptors enhances CD8+ T-cell functionality following T-cell receptor stimulation

10.6084/m9.figshare.26655274.v1figshare

Additional file 3 of The 4-1BBζ costimulatory domain in chimeric antigen receptors enhances CD8+ T-cell functionality following T-cell receptor stimulation

10.6084/m9.figshare.26655274figshare

Additional file 1 of The 4-1BBζ costimulatory domain in chimeric antigen receptors enhances CD8+ T-cell functionality following T-cell receptor stimulation

10.6084/m9.figshare.24849005figshare

Additional file 2 of The 4-1BBζ costimulatory domain in chimeric antigen receptors enhances CD8+ T-cell functionality following T-cell receptor stimulation

10.6084/m9.figshare.24849069.v1figshare

Additional file 2 of The 4-1BBζ costimulatory domain in chimeric antigen receptors enhances CD8+ T-cell functionality following T-cell receptor stimulation

10.6084/m9.figshare.24849069figshare

Additional file 1 of The 4-1BBζ costimulatory domain in chimeric antigen receptors enhances CD8+ T-cell functionality following T-cell receptor stimulation

10.6084/m9.figshare.24849005.v1figshare