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Dynamic chromatin regulatory landscape of human CAR T cell exhaustion

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2104758118Source: DataRank Database

Dynamic chromatin regulatory landscape of human CAR T cell exhaustion is a research paper published in Proceedings of the National Academy of Sciences (2021). On theSindex it has a DataRank of 1.9. It has been cited 67 times, with 61 citing works in its 1-hop citation network.

N/A

1.9DataRank · unranked

Scored on demand from live citation data

Open Access67 citations · 61 citing works in its network

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Linked data & code

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (15 grants)Impact (FWCI 3.89)OA: hybridTopics (56)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 33%Citation Network 67%

Base Score Contribution

0.633

From this paper's citation signal

Citation Network Contribution

1.3

From 48 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 61 citers.

CRISPR-edited CAR-T cells: Using CRISPR-Cas9 to Improve CAR-T Therapy
Highlights in Science Engineering and Technology20222 citations11 referencesContributes 0.100
Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness
Cell Research2023177 citations60 referencesContributes 0.086
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells
Nature Immunology2022160 citations71 referencesContributes 0.072
Exhaustion of CAR T cells: potential causes and solutions
Journal of Translational Medicine2022139 citations72 referencesContributes 0.069
Priming with LSD1 inhibitors promotes the persistence and antitumor effect of adoptively transferred T cells
Nature Communications202426 citations49 referencesContributes 0.067

Authors (13)

Rachel C. Lynn ORCID,Jeff M. Granja,Evan Weber ORCID,Maxwell R. Mumbach ORCID,Yang Zhao ORCID

Live enrichment

PubMed:34285077 PMC:PMC8325267 OpenAlex:https://openalex.org/W3183529726

Parker Institute for Cancer Immunotherapy

Grant: N/A

HHS | National Institutes of Health

Grant: RM1-HG007735

HHS | National Institutes of Health

Grant: K08-CA230188

HHS | National Institutes of Health

Grant: T32 AI07290

Howard Hughes Medical Institute

Grant: Investigator

NHGRI NIH HHS

Grant: P50 HG007735

NCI NIH HHS

Grant: R35 CA209919

NCI NIH HHS

Grant: K08 CA230188

NHGRI NIH HHS

Grant: UM1 HG009436

NHGRI NIH HHS

Grant: RM1 HG007735

NIAID NIH HHS

Grant: T32 AI007290

National Institutes of Health

Grant: 5T32AI007290-27

Molecular and Cellular Immunobiology

National Institutes of Health

Grant: 5R35CA209919-02

LncRNA mechanisms in cancer

National Institutes of Health

Grant: 5RM1HG007735-08

Center for Personal Dynamic Regulomes

National Institutes of Health

Grant: 5K08CA230188-03

Single cell epigenomics in cancer immunity and immunotherapy

FWCI

3.89

Citation Percentile

1.0%

Influential Citations

Citation Trend

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1073/pnas.2104758118

HYBRIDhttps://doi.org/10.1073/pnas.2104758118

publisherhttps://doi.org/10.1073/pnas.2104758118

publisherhttp://www.pnas.org/syndication/doi/10.1073/pnas.2104758118

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2104758118

Fields of Study

CAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell ImmunologyMedicineBiology0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsAntigens, CD19Cell LineChromatinGene Expression Regulation, NeoplasticHumansMiceNeoplasmsProgrammed Cell Death 1 ReceptorReceptors, Chimeric AntigenT-Lymphocytes

MeSH Terms

Receptors, Chimeric AntigenAnimalsCell LineChromatinHumansNeoplasmsT-LymphocytesGene Expression Regulation, NeoplasticAntigens, CD19MiceProgrammed Cell Death 1 Receptor

Keywords

ChromatinBiologyGeneEnhancerChimeric antigen receptorCellReceptorCell biologyT cellGeneticsGene expressionImmune systemepigenomicsCancer ImmunotherapyEnhancer EditingReceptors, Chimeric AntigenT-LymphocytesAntigens, CD19Programmed Cell Death 1 ReceptorBiological SciencesCell LineGene Expression Regulation, NeoplasticMiceNeoplasmsAnimalsHumans

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being