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Structural Dynamics of Cytochrome P450 3A4 in the Presence of Substrates and Cytochrome P450 Reductase

Biochemistry(2021)10.1021/acs.biochem.1c00178Source: DataRank Database

Structural Dynamics of Cytochrome P450 3A4 in the Presence of Substrates and Cytochrome P450 Reductase is a research paper published in Biochemistry (2021). On theSindex it has a DataRank of 0. It has been cited 15 times.

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Open Access15 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (6 grants)Impact (FWCI 1.42)OA: greenTopics (60)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Irina F. Sevrioukova ORCID,Christopher J. Thibodeaux ORCID,Karine Auclair ORCID,Julie Ducharme

Live enrichment

PubMed:34196520 PMC:PMC8711236 OpenAlex:https://openalex.org/W3177308558

Fonds de Recherche du Qu??bec - Nature et Technologies

Grant: FRQNT-2020-RS4-265155-CCVC

Natural Sciences and Engineering Research Council of Canada

Grant: RGPIN-2017-04107

National Institutes of Health

Grant: ES025767

NIEHS NIH HHS

Grant: R01 ES025767

Natural Sciences and Engineering Research Council of Canada

Grant: unidentified

unidentified

National Institutes of Health

Grant: 5R01ES025767-08

Toxicological importance of CYP3A4 catalysis and inhibition

FWCI

1.42

Citation Percentile

0.8%

Citation Trend

2021

2022

2023

2024

2025

2026

greenLicense: https://www.biorxiv.org/about/FAQ#license

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8711236

publisherhttps://pubs.acs.org/doi/pdf/10.1021/acs.biochem.1c00178

journalhttps://doi.org/10.1021/acs.biochem.1c00178

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34196520

Fields of Study

Pharmacogenetics and Drug MetabolismAnalytical Chemistry and ChromatographyComputational Drug Discovery Methods0301 basic medicine03 medical and health sciencesAnimalsCytochrome P-450 CYP3AHumansModels, MolecularNADPH-Ferrihemoprotein ReductaseProtein BindingProtein ConformationProtein Interaction MapsRatsSubstrate Specificity

MeSH Terms

AnimalsHumansModels, MolecularNADPH-Ferrihemoprotein ReductaseProtein BindingProtein ConformationSubstrate SpecificityRatsCytochrome P-450 CYP3AProtein Interaction Maps

Keywords

ChemistryCYP3A4Hydrogen–deuterium exchangeCytochrome P450StereochemistryAllosteric regulationHelix (gastropod)EnzymeCytochrome P450 reductaseLigand (biochemistry)BiophysicsBiochemistryCytochrome cReceptorHydrogenBiologyModels, Molecular570Protein ConformationMolecularPeptides and proteinsRatsSubstrate SpecificityModels617Structural dynamicsAnimalsCytochrome P-450 CYP3AHumansReaction rate theorySurface interactionsProtein Interaction MapsHydrogen isotopesNADPH-Ferrihemoprotein ReductaseProtein Binding

Sustainable Development Goals

SDG 0: Good health and well-being

Structural Dynamics of Cytochrome P450 3A4 in the Presence of Substrates and Cytochrome P450 Reductase

FAIR Checklist

Authors (4)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)