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Herboxidiene Features That Mediate Conformation-Dependent SF3B1 Interactions to Inhibit Splicing

ACS Chemical Biology(2021)10.1021/acschembio.0c00965Source: DataRank Database

Herboxidiene Features That Mediate Conformation-Dependent SF3B1 Interactions to Inhibit Splicing is a research paper published in ACS Chemical Biology (2021). On theSindex it has a DataRank of 0. It has been cited 12 times.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (8 grants)OA: greenTopics (93)IDs (PubMed, PMC)

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Authors (7)

Srinivasa Rao Allu ORCID,Patricia Mendez ORCID,Guddeti Chandrashekar Reddy,Hannah M. Maul-Newby ORCID,Arun K. Ghosh ORCID

Live enrichment

PubMed:33617218 PMC:PMC8189251

National Institutes of Health

Grant: R01GM72649

National Institutes of Health

Grant: R25GM058903

National Science Foundation

Grant: DGE-1842400

NIGMS NIH HHS

Grant: R01 GM072649

NIGMS NIH HHS

Grant: R01 GM122279

National Institutes of Health

Grant: 5R25GM058903-05

University of California, Santa Cruz, IMSD Program

National Institutes of Health

Grant: 5R01GM072649-07

Interpreting the Structure of the Spliceosome

National Science Foundation

Grant: 1842400

Graduate Research Fellowship Program(GRFP)

greenLicense: STM Policy #29

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8189251

publisherhttps://pubs.acs.org/doi/pdf/10.1021/acschembio.0c00965

https://doi.org/10.1021/acschembio.0c00965

https://www.biorxiv.org/content/biorxiv/early/2020/11/29/2020.11.18.387712.full.pdf

https://pubmed.ncbi.nlm.nih.gov/33617218

Fields of Study

0301 basic medicine03 medical and health sciencesAdenosine TriphosphateBase SequenceBinding SitesFatty AlcoholsHeLa CellsHumansModels, MolecularPhosphoproteinsProtein BindingProtein ConformationPyransRNA SplicingRNA Splicing FactorsRNA, MessengerRibonucleoprotein, U2 Small NuclearSpliceosomesStructure-Activity RelationshipTemperature

MeSH Terms

Hela CellsSpliceosomesHumansFatty AlcoholsPyransRibonucleoprotein, U2 Small NuclearPhosphoproteinsRNA, MessengerAdenosine TriphosphateTemperatureRNA SplicingBinding SitesBase SequenceProtein ConformationProtein BindingStructure-Activity RelationshipModels, MolecularRNA Splicing FactorsHeLa Cells

Keywords

Models, MolecularProtein ConformationMessengerSF 3B side chainsSF 3B inhibitorsBiochemistryU 2 snRNP interactionsAdenosine TriphosphateSF 3B conformationsSF 3BModelsU 2 snRNPinhibitor interactionsTemperatureBiological Sciencesinfluence inhibitor interactionsRNA Splicing FactorsFatty AlcoholsProtein BindingChemical Sciences not elsewhere classified572branch point sequenceRNA SplicingMediate Conformation-Dependent SF 3.Biophysicscancer cell growthMedicinal and Biomolecular ChemistryStructure-Activity RelationshipVirologyspliceosome SF 3BOrder-of-addition experiments showinhibitor binding channelHumansRNA, MessengerMolecular Biologybranch binding sequencePyransPharmacologycarboxylic acid substituentU2 Small NuclearBinding SitesBase SequenceOrganic ChemistryMolecularRibonucleoproteinRibonucleoprotein, U2 Small NuclearPhosphoproteinsSF 3B transitionATPChemical sciencesHela Cellsspliceosome assemblySpliceosomesRNA