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Discovery of RNA-Reactive Small Molecules Guides the Design of Electrophilic Modules for RNA-Specific Covalent Binders

Journal of the American Chemical Society(2025)10.1021/jacs.5c06802Source: DataRank Database

Discovery of RNA-Reactive Small Molecules Guides the Design of Electrophilic Modules for RNA-Specific Covalent Binders is a research paper published in Journal of the American Chemical Society (2025). On theSindex it has a DataRank of 0. It has been cited 11 times.

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Open Access11 citations

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Enrichment:Funding (6 grants)Impact (FWCI 4.76)OA: hybridTopics (34)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Patrick R. A. Zanon ORCID,Amirhossein Taghavi ORCID,Kisu Sung ORCID,Matthew D. Disney ORCID,Noah A. Springer ORCID

Live enrichment

PubMed:40951988 PMC:PMC12464989 OpenAlex:https://openalex.org/W4414168487

National Science Foundation Graduate Research Fellowship Program

Grant: 2235200

Graduate Research Fellowship Program (GRFP)

National Institute of Neurological Disorders and Stroke

Grant: R35 NS116846

Deutsche Forschungsgemeinschaft

Grant: 515396515

Muscular Dystrophy Association

Grant: 1069959

National Institutes of Health

Grant: 1R35NS116846-01

Design of precision small molecules targeting RNA repeating transcripts to manipulate and study disease biology

Deutsche Forschungsgemeinschaft

Grant: unidentified

unidentified

FWCI

4.76

Citation Percentile

1.0%

Citation Trend

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://pubs.acs.org/doi/pdf/10.1021/jacs.5c06802?ref=article_openPDF

publisherhttps://pubs.acs.org/doi/pdf/10.1021/jacs.5c06802?ref=article_openPDF

publisherhttps://pubs.acs.org/doi/pdf/10.1021/jacs.5c06802

journalhttps://doi.org/10.1021/jacs.5c06802

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40951988

Fields of Study

RNA and protein synthesis mechanismsRNA Research and SplicingClick Chemistry and Applications01 natural sciences0104 chemical sciencesRNASmall Molecule LibrariesBenzimidazolesDrug DesignLigandsDrug DiscoveryMolecular Structure

MeSH Terms

BenzimidazolesLigandsRNADrug DesignMolecular StructureSmall Molecule LibrariesDrug Discovery

Keywords

ElectrophileCovalent bondSmall moleculeRNANucleophileNon-covalent interactionsGuanineDNASmall Molecule LibrariesMolecular StructureDrug DesignDrug DiscoveryBenzimidazolesLigandsArticle

Discovery of RNA-Reactive Small Molecules Guides the Design of Electrophilic Modules for RNA-Specific Covalent Binders

FAIR Checklist

Authors (5)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)