Matthew D. Disney

Also affiliated with Scripps Institution of Oceanography, Scripps (United States), The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology

Biochemistry, Genetics and Molecular BiologyNeuroscience

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 2%percentile

3.1Author DataRank

Indexed papers

2in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 2 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

A map of the SARS-CoV-2 RNA structurome

NAR Genomics and Bioinformatics(2021)10.1093/nargab/lqab043

Top 7%

3.1DataRank

Top 7%96 citations

Collin A. O’Leary, Van S. Tompkins, Jake M. Peterson, Hafeez S. Haniff, Christopher J. Williams +3 more

Papers

Driven by 57 papers — median percentile 93. Top paper: “A map of the SARS-CoV-2 RNA structurome”.

A map of the SARS-CoV-2 RNA structurome

NAR Genomics and Bioinformatics(2021)10.1093/nargab/lqab043

Top 7%

3.1DataRank

Top 7%96 citations

Collin A. O’Leary, Van S. Tompkins, Jake M. Peterson, Hafeez S. Haniff, Christopher J. Williams +3 more

Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit

The Journal of Infectious Diseases(2021)10.1093/infdis/jiab305

N/A

2.2DataRank · unranked

41 citations

James M. Anderson, Annaliesa S. Anderson, David Baker, Jay Bradner, Kyle R. Brimacombe +37 more

Methods to identify and optimize small molecules interacting with RNA (SMIRNAs)

Drug Discovery Today(2019)10.1016/j.drudis.2019.06.019

N/A

1.2DataRank · unranked

29 citations

Simon Vézina-Dawod, Matthew D. Disney, Andrei Ursu

A blood–brain penetrant RNA-targeted small molecule triggers elimination of r(G 4 C 2 ) exp in c9ALS/FTD via the nuclear RNA exosome

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2210532119

N/A

0.477DataRank · unranked

23 citations

Samantha M. Meyer, Rita Fuerst, Yuquan Tong, Yue Li, Raphael I. Benhamou +11 more

Streamlined Fragment-Based Discovery Platform for Targeting Structured RNAs

ACS Chemical Biology(2025)10.1021/acschembio.5c00372

N/A

0.165DataRank · unranked

2 citations

Amirhossein Taghavi, Patrick R. A. Zanon, Matthew D. Disney, Yilin Jia

Design of an Orally Bioavailable Small Molecule That Modulates the Microtubule-Associated Protein Tau’s Pre-mRNA Splicing

ACS Chemical Biology(2025)10.1021/acschembio.5c00260

N/A

0.104DataRank · unranked

1 citations

Amirhossein Taghavi, Masahito Abe, Haruo Aikawa, Yoshihiro Akahori, Jonathan L. Chen +6 more

Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD

ACS Chemical Biology(2020)10.1021/acschembio.0c00049

N/A

0DataRank · unranked

20 citations

Kye Won Wang, Jessica A. Bush, Shruti Choudhary, Jonathan L. Chen, Jared T. Baisden +6 more

Progress toward the development of the small molecule equivalent of small interfering RNA

Current Opinion in Chemical Biology(2020)10.1016/j.cbpa.2020.01.001

N/A

0DataRank · unranked

17 citations

Blessy M. Suresh, Raphael I. Benhamou, Jessica L. Childs‐Disney, Matthew D. Disney

An in silico map of the SARS-CoV-2 RNA Structurome

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.04.17.045161

N/A

0DataRank · unranked

55 citations

Jake M. Peterson, Hafeez S. Haniff, Jonathan H. Chen, Christopher J. Williams, Maison Grefe +3 more

A small molecule that binds an RNA repeat expansion stimulates its decay via the exosome complex

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.11.088427

N/A

0DataRank · unranked

3 citations

Raphael I. Benhamou, Suzanne G. Rzuczek, Shruti Choudhary, Zhenzhi Tang, Jonathan L. Chen +7 more

Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G 4 C 2 ) repeat expansion in vitro and in vivo ALS models

Science Translational Medicine(2021)10.1126/scitranslmed.abd5991

N/A

0DataRank · unranked

80 citations

Haruo Aikawa, Rita Fuerst, Yue Li, Andrei Ursu, Samantha M. Meyer +19 more

A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype

Cell chemical biology(2021)10.1016/j.chembiol.2021.07.006

N/A

0DataRank · unranked

32 citations

Xiaohui Liu, Yuquan Tong, Samantha M. Meyer, Laurent Knerr, Malin Lemurell +5 more

A Small Molecule Exploits Hidden Structural Features within the RNA Repeat Expansion That Causes c9ALS/FTD and Rescues Pathological Hallmarks

ACS Chemical Neuroscience(2021)10.1021/acschemneuro.1c00470

N/A

0DataRank · unranked

24 citations

Jared T. Baisden, Jessica A. Bush, Amirhossein Taghavi, Shruti Choudhary, Yong‐Jie Zhang +5 more

A Druglike Small Molecule that Targets r(CCUG) Repeats in Myotonic Dystrophy Type 2 Facilitates Degradation by RNA Quality Control Pathways

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c00414

N/A

0DataRank · unranked

17 citations

Masahito Abe, Raphael I. Benhamou, Alicia J. Angelbello, Kamalakannan Vishnu, Jonathan L. Chen +3 more

Small molecule 1a reduces FMRpolyG-mediated toxicity in in vitro and in vivo models for FMR1 premutation

Human Molecular Genetics(2021)10.1093/hmg/ddab143

N/A

0DataRank · unranked

14 citations

Ronald A.M. Buijsen, Lucas Verwegen, Lies‐Anne Severijnen, Helen de Boer, Valerie Boumeester +7 more

Bioinformatic Searching for Optimal RNA Targets of Dimeric Compounds Informs Design of a MicroRNA-27a Inhibitor

ACS Chemical Biology(2021)10.1021/acschembio.1c00395

N/A

0DataRank · unranked

6 citations

Shruti Choudhary, Elizabeth Lekah, Yuquan Tong, Matthew D. Disney, Raphael I. Benhamou

Targeting RNA structures with small molecules

Nature Reviews Drug Discovery(2022)10.1038/s41573-022-00521-4

N/A

0DataRank · unranked

592 citations

Xueyi Yang, Quentin M. R. Gibaut, Yuquan Tong, Robert Batey, Matthew D. Disney +1 more

DNA-Encoded Library Screening To Inform Design of a Ribonuclease Targeting Chimera (RiboTAC)

Journal of the American Chemical Society(2022)10.1021/jacs.2c07217

N/A

0DataRank · unranked

76 citations

Toru Tanaka, Patrick R. A. Zanon, Jared T. Baisden, Daniel Abegg, Xueyi Yang +6 more

Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA

Journal of the American Chemical Society(2022)10.1021/jacs.2c01929

N/A

0DataRank · unranked

75 citations

Quentin M. R. Gibaut, Warren B. Rouse, Jessica L. Childs‐Disney, Blessy M. Suresh, Daniel Abegg +6 more

Rational Approach to Identify RNA Targets of Natural Products Enables Identification of Nocathiacin as an Inhibitor of an Oncogenic RNA

ACS Chemical Biology(2022)10.1021/acschembio.1c00952

N/A

0DataRank · unranked

9 citations

Hafeez S. Haniff, Blessy M. Suresh, Dong Yang, Peiyuan Zhang, Gogce Crynen +7 more

A meditation on accelerating the development of small molecule medicines targeting RNA

Expert Opinion on Drug Discovery(2022)10.1080/17460441.2022.2084528

N/A

0DataRank · unranked

4 citations

Jessica L. Childs‐Disney, Matthew D. Disney, Xueyi Yang

Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit

Neurology and Therapy(2023)10.1007/s40120-023-00548-8

N/A

0DataRank · unranked

34 citations

Bryan J. Traynor, Janice Robertson, Ludo Van Den Bosch, Sami J. Barmada, Clive N. Svendsen +49 more

Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG)exp Degrader in Myotonic Dystrophy

ACS Central Science(2023)10.1021/acscentsci.2c01223

N/A

0DataRank · unranked

26 citations

Jessica A. Bush, Yuquan Tong, Jared T. Baisden, Amirhossein Taghavi, Hailey Olafson +5 more

Fragment-Based Approaches to Identify RNA Binders

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c00034

N/A

0DataRank · unranked

23 citations

Amirhossein Taghavi, Jessica L. Childs‐Disney, Matthew D. Disney, Blessy M. Suresh

Altering the Cleaving Effector in Chimeric Molecules that Target RNA Enhances Cellular Selectivity

ACS Chemical Biology(2023)10.1021/acschembio.3c00363

N/A

0DataRank · unranked

15 citations

Yuquan Tong, Daniel Abegg, Alexander Adibekian, Jessica L. Childs‐Disney, Matthew D. Disney +1 more

Conformational dynamics of RNA G4C2 and G2C4 repeat expansions causing ALS/FTD using NMR and molecular dynamics studies

Nucleic Acids Research(2023)10.1093/nar/gkad403

N/A

0DataRank · unranked

13 citations

Jared T. Baisden, Jessica L. Childs‐Disney, Ilyas Yildirim, Matthew D. Disney, Amirhossein Taghavi

DNA‐Encoded Libraries and Their Application to RNA

Israel Journal of Chemistry(2023)10.1002/ijch.202300073

N/A

0DataRank · unranked

13 citations

Jessica L. Childs‐Disney, M. Paegel, Matthew D. Disney, Xueyi Yang

Optimization of a Protein-Targeted Medicine into an RNA-Specific Small Molecule

ACS Chemical Biology(2023)10.1021/acschembio.3c00476

N/A

0DataRank · unranked

8 citations

Toru Tanaka, Amirhossein Taghavi, Jared T. Baisden, Maison Grefe, Matthew D. Disney +1 more

Broad-spectrum metastasis suppressing compounds and therapeutic uses thereof in human tumors

Scientific Reports(2023)10.1038/s41598-023-47478-x

N/A

0DataRank · unranked

3 citations

Jonathan L. Chen, Jessica L. Childs‐Disney, Matthew D. Disney, Dan Canaani, Pnina Gottfried Komlosh

Conformational Dynamics of RNA G4C2 and C2G4 Repeat Expansions causing ALS/FTD using NMR and Molecular Dynamics Studies

ChemRxiv(2023)10.26434/chemrxiv-2023-3g7w7

N/A

0DataRank · unranked

0 citations

Amirhossein Taghavi, Jared T. Baisden, Jessica L. Childs‐Disney, Ilyas Yildirim, Matthew D. Disney

Decreasing the intrinsically disordered protein α-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2306682120

N/A

0DataRank · unranked

47 citations

Peiyuan Zhang, Xueyi Yang, Xiaohui Liu, Jie Zhang, Magda Grudniewska +10 more

Targeting RNA with small molecules, from RNA structures to precision medicines: IUPHAR review: 40

British Journal of Pharmacology(2024)10.1111/bph.17308

N/A

0DataRank · unranked

22 citations

Jessica L. Childs‐Disney, Matthew D. Disney, Yuquan Tong

Transcriptome-Wide, Unbiased Profiling of Ribonuclease Targeting Chimeras

Journal of the American Chemical Society(2024)10.1021/jacs.4c04717

N/A

0DataRank · unranked

19 citations

Xiaoxuan Su, Warren B. Rouse, Jessica L. Childs‐Disney, Amirhossein Taghavi, Patrick R. A. Zanon +5 more

Protocol for transcriptome-wide mapping of small-molecule RNA-binding sites in live cells

STAR Protocols(2024)10.1016/j.xpro.2024.103271

N/A

0DataRank · unranked

9 citations

Patrick R. A. Zanon, Xueyi Yang, Xiaoxuan Su, Jessica L. Childs‐Disney, Matthew D. Disney +1 more

Heterobifunctional small molecules to modulate RNA function

Trends in Pharmacological Sciences(2024)10.1016/j.tips.2024.03.006

N/A

0DataRank · unranked

9 citations

Yuquan Tong, Jessica L. Childs‐Disney, Matthew D. Disney, Sandra Kovachka

NMR structures of small molecules bound to a model of a CUG RNA repeat expansion

Bioorganic & Medicinal Chemistry Letters(2024)10.1016/j.bmcl.2024.129888

N/A

0DataRank · unranked

6 citations

Amirhossein Taghavi, Alexander J. Frank, Matthew A. Fountain, Shruti Choudhary, Soma Roy +3 more

NMR structures of small molecules bound to a model of an RNA CUG repeat expansion

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.06.21.600119

N/A

0DataRank · unranked

2 citations

Amirhossein Taghavi, Alexander J. Frank, Matthew A. Fountain, Shruti Choudhary, Soma Roy +3 more

NMR structures and magnetic force spectroscopy studies of small molecules binding to models of an RNA CAG repeat expansion

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.08.20.608150

N/A

0DataRank · unranked

0 citations

Jonathan L. Chen, Zhen Wang, Krishshanthi Sinnadurai, David Georges Salthouse, Matthew Ozon +6 more

The evolution and application of RNA-focused small molecule libraries

RSC Chemical Biology(2025)10.1039/d4cb00272e

N/A

0DataRank · unranked

17 citations

Noah A. Springer, Patrick R. A. Zanon, Yanjun Li, Chenglong Li, Jessica L. Childs‐Disney +2 more

Covalent Probes Reveal Small-Molecule Binding Pockets in Structured RNA and Enable Bioactive Compound Design

Journal of the American Chemical Society(2025)10.1021/jacs.5c11898

N/A

0DataRank · unranked

8 citations

Jielei Wang, Amirhossein Taghavi, Yilin Jia, Taro Asaba, Karen C. Wolff +14 more

Discovery of RNA-Reactive Small Molecules Guides the Design of Electrophilic Modules for RNA-Specific Covalent Binders

Journal of the American Chemical Society(2025)10.1021/jacs.5c06802

N/A

0DataRank · unranked

11 citations

Patrick R. A. Zanon, Amirhossein Taghavi, Kisu Sung, Matthew D. Disney, Noah A. Springer

Mapping small molecule–RNA binding sites via Chem-CLIP synergized with capillary electrophoresis and nanopore sequencing

Nucleic Acids Research(2025)10.1093/nar/gkaf231

N/A

0DataRank · unranked

10 citations

Jielei Wang, Noah A. Springer, Patrick R. A. Zanon, Yilin Jia, Xiaoxuan Su +2 more

Structure-Guided Design of a Bioactive Covalent Small Molecule Targeting a Riboswitch

Journal of the American Chemical Society(2025)10.1021/jacs.5c13219

N/A

0DataRank · unranked

6 citations

Xueyi Yang, Kyle A. Dickerson, Patrick R. A. Zanon, Noah A. Springer, Jielei Wang +5 more

Chemical Tagging of N -Alkylamine-Containing Natural Products and Pharmaceuticals through C( sp 3 )–H Functionalization

Journal of the American Chemical Society(2025)10.1021/jacs.5c11236

N/A

0DataRank · unranked

4 citations

Cunyuan Zhao, Tenghui Wang, Andrew D. Steele, Manas Joshi, Soichiro Mori +5 more

A Live-Cell NanoBRET Assay to Monitor RNA–Protein Interactions and Their Inhibition by Small Molecules

ACS Central Science(2025)10.1021/acscentsci.5c00705

N/A

0DataRank · unranked

2 citations

Amirhossein Taghavi, Elizabeth A. Caine, Ryuichi Sekioka, Veronika Rajchin, James M. Burke +4 more

Linker Optimization Enhances the Potency of Ribonuclease-Targeting Chimeras in Cancer Models

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c00749

N/A

0DataRank · unranked

5 citations

Sandra Kovachka, Tenghui Wang, Michael D. Cameron, Jessica L. Childs‐Disney, Matthew D. Disney +1 more

Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.1914286117

N/A

0DataRank · unranked

187 citations

Haruo Aikawa, Yue Li, Jessica L. Childs‐Disney, Daniel Abegg, Dominic G. Hoch +9 more

Unbiased RNA Degrader Identification Uncovers an LC3B-Recruiting Chimera for COL15A1 mRNA Degradation

Journal of the American Chemical Society(2025)10.1021/jacs.5c14363

N/A

0DataRank · unranked

1 citations

Yuquan Tong, Patrick R. A. Zanon, Jielei Wang, Toru Tanaka, Jessica L. Childs‐Disney +2 more

Discovery of RNA-Reactive Small Molecules Guides Design of Electrophilic Modules for RNA-Specific Covalent Binders

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.22.649986

N/A

0DataRank · unranked

3 citations

Patrick R. A. Zanon, Amirhossein Taghavi, Kisu Sung, Matthew D. Disney, Noah A. Springer

Design of an orally bioavailable small molecule that modulates the microtubule-associated protein tau’s pre-mRNA splicing

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.30.651234

N/A

0DataRank · unranked

0 citations

Amirhossein Taghavi, Masahito Abe, Haruo Aikawa, Yoshihiro Akahori, Jonathan L. Chen +6 more

RNA-Focused DNA-Encoded Library Construction, Screening, and Integration of Docking Identify Bioactive Ligands of Pathogenic r(G 4 C 2 ) exp RNA

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.11.06.686979

N/A

0DataRank · unranked

0 citations

Amirhossein Taghavi, Yoshihiro Akahori, Martina Pedrini, Takahiro Ishii, Matthew D. Disney +1 more

Sustained Epigenetic Reactivation in Fragile X Neurons with an RNA-Binding Small Molecule

Genes(2025)10.3390/genes16030278

N/A

0DataRank · unranked

2 citations

Jason G. Dumelie, Gabriele Ciceri, Wang-Yong Yang, Matthew D. Disney, Lorenz Studer +2 more

Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.1905057117

N/A

0DataRank · unranked

121 citations

Hye-Jin Park, Jie Zhang, Eunsung Junn, Ryan J. Andrews, Sai Pradeep Velagapudi +9 more

Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing

Journal of the American Chemical Society(2020)10.1021/jacs.0c00768

N/A

0DataRank · unranked

81 citations

Peiyuan Zhang, Masahito Abe, Haruo Aikawa, Liying Zhang, Alexander J. Frank +14 more

A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex

Cell chemical biology(2020)10.1016/j.chembiol.2020.10.007

N/A

0DataRank · unranked

48 citations

Raphael I. Benhamou, Suzanne G. Rzuczek, Shruti Choudhary, Zhenzhi Tang, Jonathan L. Chen +7 more

Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In Vivo

Cell Reports(2020)10.1016/j.celrep.2020.107616

N/A

0DataRank · unranked

48 citations

Zachary T. McEachin, Jeannie Chew, Alexander R. Burch, Karen Jansen‐West, Jimei Tong +18 more

Macrocyclization of a Ligand Targeting a Toxic RNA Dramatically Improves Potency

ChemBioChem(2020)10.1002/cbic.202000445

N/A

0DataRank · unranked

7 citations

Simon Vézina‐Dawod, Shruti Choudhary, Kye Won Wang, Samantha M. Meyer, Ilyas Yildirim +2 more

Matthew D. Disney

Indexed papers

Top data-sharing exemplar

Papers