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Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia

Leukemia(2021)10.1038/s41375-021-01455-3Source: DataRank Database

Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia is a research paper published in Leukemia (2021). On theSindex it has a DataRank of 0. It has been cited 12 times.

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Open Access12 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (9 grants)OA: hybridTopics (48)IDs (PubMed, PMC)SDGs (1)

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Accessible (1/2)

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Reusable (0/3)

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Authors (15)

Anjelika Gasilina,Mark Wunderlich ORCID,Yuan Lin ORCID,Marcel Buchholzer ORCID,Oliver H.F. Krumbach

Live enrichment

PubMed:34711926 PMC:PMC8885421

U.S. Department of Health & Human Services | NIH | National Cancer Institute

Grant: R01CA237016

U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences

Grant: 2UL1TR001425

U.S. Department of Health & Human Services | NIH | Center for Information Technology

Grant: R50CA211404

NCATS NIH HHS

Grant: UL1 TR001425

NCI NIH HHS

Grant: R01 CA115611

National Institutes of Health

Grant: 5R01CA115611-02

Ras, Cycling and Inhibition.

National Institutes of Health

Grant: 2UL1TR001425-05A1

Center for Clinical and Translational Science and Training

National Institutes of Health

Grant: 5R50CA211404-04

Therapeutic insights through patient derived leukemia xenografts

National Institutes of Health

Grant: 5R01CA237016-04

Targeted Inhibition in Leukemia

hybridLicense: cc-by

publisherhttps://www.nature.com/articles/s41375-021-01455-3.pdf

publisherhttps://www.nature.com/articles/s41375-021-01455-3

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8885421

Europe_PMChttps://europepmc.org/articles/PMC8885421

Europe_PMChttps://europepmc.org/articles/PMC8885421?pdf=render

Fields of Study

0301 basic medicine03 medical and health sciencesAnimalsAntineoplastic AgentsDrug Resistance, NeoplasmFemaleHumansMaleMice, Inbred C57BLMice, SCIDPrecursor Cell Lymphoblastic Leukemia-LymphomaProtein Kinase InhibitorsProto-Oncogene Proteins c-vavSignal TransductionSmall Molecule LibrariesTumor Cells, CulturedMice

MeSH Terms

Tumor Cells, CulturedAnimalsMice, Inbred C57BLHumansMiceMice, SCIDAntineoplastic AgentsProtein Kinase InhibitorsSignal TransductionDrug Resistance, NeoplasmFemaleMaleProto-Oncogene Proteins c-vavPrecursor Cell Lymphoblastic Leukemia-LymphomaSmall Molecule Libraries

Keywords

MaleAntineoplastic AgentsMice, SCIDPrecursor Cell Lymphoblastic Leukemia-LymphomaArticleMice, Inbred C57BLSmall Molecule LibrariesMiceDrug Resistance, NeoplasmTumor Cells, CulturedAnimalsHumansFemaleProto-Oncogene Proteins c-vavProtein Kinase InhibitorsSignal Transduction

Sustainable Development Goals

SDG 3: 3. Good health