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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

Nature(2020)10.1038/s41586-020-2286-9Source: DataRank Database

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing is a research paper published in Nature (2020). On theSindex it has a DataRank of 1.3. It has been cited 4,829 times.

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1.3DataRank · unranked

Scored on demand from live citation data

Open Access4,829 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (47 grants)Impact (FWCI 527.52)OA: bronzeTopics (182)Linked Datasets (25)DataCite Reuse (25)IDs (PubMed, PMC, OpenAlex)Annotations (5)SDGs (2)

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Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

1.3

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

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Authors (100)

Gwendolyn M. Jang ORCID,Mehdi Bouhaddou ORCID,Jiewei Xu ORCID,Kirsten Obernier ORCID,Kris M. White ORCID

Live enrichment

PubMed:32353859 PMC:PMC7431030 OpenAlex:https://openalex.org/W3022285953

NCI NIH HHS

Grant: F32 CA236347

NIAID NIH HHS

Grant: P30 AI027763

NCI NIH HHS

Grant: R01 CA244550

NHGRI NIH HHS

Grant: R01 HG009979

NIAID NIH HHS

Grant: U19 AI135990

NIH HHS

Grant: 1R01CA244550

NIGMS NIH HHS

Grant: F32 GM133144

NCI NIH HHS

Grant: P30 CA023100

NIAID NIH HHS

Grant: P50 AI150476

NIAID NIH HHS

Grant: R01 AI122747

NIGMS NIH HHS

Grant: R01 GM024485

NCI NIH HHS

Grant: T32 CA108462

NCI NIH HHS

Grant: F32 CA239333

NIAID NIH HHS

Grant: R01 AI118974

NCI NIH HHS

Grant: R01 CA221969

NIAID NIH HHS

Grant: HHSN272201400008C

NIAID NIH HHS

Grant: R01 AI120694

NIGMS NIH HHS

Grant: R01 GM140440

NIGMS NIH HHS

Grant: R35 GM118099

NIGMS NIH HHS

Grant: T32 GM008284

NIH HHS

Grant: 1F32CA236347-01

Targeting a Splicing-mediated Resistance Mechanism in Prostate Cancer

NHLBI NIH HHS

Grant: K08 HL124068

NIAID NIH HHS

Grant: R01 AI143292

NIGMS NIH HHS

Grant: R01 GM117189

NIGMS NIH HHS

Grant: R35 GM122481

NIGMS NIH HHS

Grant: T32 GM064337

NIAID NIH HHS

Grant: U19 AI135972

NCI NIH HHS

Grant: F30 CA239476

NIAID NIH HHS

Grant: P01 AI063302

NIAID NIH HHS

Grant: P01 AI120943

NIAID NIH HHS

Grant: T32 AI060537

NIGMS NIH HHS

Grant: T32 GM067547

European Commission

Grant: 653316

European Virus Archive goes global

National Institutes of Health

Grant: 5R01CA244550-03

Inhibitors of the G protein GNAS which drives pancreatic tumorigenesis

National Institutes of Health

Grant: 5P50AI150476-14

HARC Center: HIV Accessory and Regulatory Complexes

National Institutes of Health

Grant: 5R01AI120694-02

Discovery of novel, ubiquitin-regulated mechanisms of TB control by macrophages

National Institutes of Health

Grant: 5R01CA221969-05

Improving the efficacy of mTOR inhibition

National Institutes of Health

Grant: 5F32CA236347-02

Targeting a Splicing-mediated Resistance Mechanism in Prostate Cancer

National Institutes of Health

Grant: 5U19AI135972-04

Fluomics: The Next Generation

National Institutes of Health

Grant: 5R35GM122481-05

Development and Testing of New Computational Methods for Ligand Discovery and Mechanism

National Institutes of Health

Grant: 1R01AI122747-01

Decoding the Chlamydia inclusion membrane protein-host protein interactome

National Institutes of Health

Grant: 5U19AI135990-03

HPMI: Host Pathogen Mapping Initiative

National Institutes of Health

Grant: 3R01AI143292-05S1

Novel VP30-host Interactions that Negatively Regulate Ebola Virus Infection

European Commission

Grant: 871029

European Virus Archive GLOBAL

National Institutes of Health

Grant: 1K08HL124068-01A1

Probing the multiple roles of the PCSK9 active site using chemical biology

Howard Hughes Medical Institute

FWCI

527.52

Citation Percentile

1.0%

Citation Trend

2012

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bronzeLicense: Springer TDM

journalhttps://www.nature.com/articles/s41586-020-2286-9.pdf

publisherhttps://www.nature.com/articles/s41586-020-2286-9.pdf

publisherhttp://www.nature.com/articles/s41586-020-2286-9.pdf

publisherhttp://www.nature.com/articles/s41586-020-2286-9

journalhttps://doi.org/10.1038/s41586-020-2286-9

Fields of Study

Computational Drug Discovery MethodsSARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approaches0303 health sciences03 medical and health sciences0301 basic medicineAnimalsAntiviral AgentsBetacoronavirusCOVID-19Chlorocebus aethiopsCloning, MolecularCoronavirus InfectionsDrug Evaluation, PreclinicalDrug RepositioningHEK293 CellsHost-Pathogen InteractionsHumansImmunity, InnateMass SpectrometryMolecular Targeted TherapyPandemicsPneumonia, ViralProtein BindingProtein BiosynthesisProtein DomainsProtein Interaction MappingProtein Interaction MapsReceptors, sigmaSARS-CoV-2SKP Cullin F-Box Protein LigasesVero CellsViral ProteinsCOVID-19 Drug Treatment

MeSH Terms

Protein DomainsBetacoronavirusCOVID-19SARS-CoV-2COVID-19 Drug TreatmentAnimalsAntiviral AgentsChlorocebus aethiopsCloning, MolecularDrug Evaluation, PreclinicalHumansImmunity, InnatePneumonia, ViralProtein BindingMass SpectrometryProtein BiosynthesisVero CellsViral ProteinsReceptors, sigmaCoronavirus InfectionsProtein Interaction MappingSKP Cullin F-Box Protein LigasesHost-Pathogen InteractionsHEK293 CellsDrug RepositioningPandemicsMolecular Targeted TherapyProtein Interaction Maps

Keywords

Drug repositioningCoronavirusDruggabilityRepurposingVirologyDrugDrug discoverySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BiologyPharmacologyMedicineComputational biologyCoronavirus disease 2019 (COVID-19)BioinformaticsDiseaseInfectious disease (medical specialty)GeneGenetics3102 Bioinformatics and Computational Biology (for-2020)General Science & Technology (science-metrix)Mass Spectrometry (mesh)Protein Interaction Mapping (mesh)Mass SpectrometryCoronaviruses Therapeutics and InterventionsProtein Interaction MappingAnimals (mesh)Molecular Targeted Therapy32 Biomedical and Clinical Sciences (for-2020)LungProtein Interaction Maps (mesh)Protein Biosynthesis (mesh)5.1 Pharmaceuticals[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/VirologyPneumonia & InfluenzaDevelopment of treatments and therapeutic interventionsInfection570Pneumonia, ViralBioinformatics and Computational Biology610Antiviral AgentsEmerging Infectious Diseases (rcdc)ArticleViral ProteinsBetacoronavirusSíndrome respiratorio agudo graveProtein Domains5.1 Pharmaceuticals (hrcs-rac)BiodefenseHumansHEK293 Cells (mesh)31 Biological Sciences (for-2020)PreventionPandemics (mesh)ImmunityCoronaviruses (rcdc)MolecularPneumoniaHost-Pathogen Interactions (mesh)Vero Cells (mesh)Immunity, InnateInfectious Diseases (rcdc)Chlorocebus aethiops (mesh)Drug EvaluationInnate (mesh)CloningViral Proteins (mesh)CoronavirusesDrug Evaluation, PreclinicalsigmaReceptorsChlorocebus aethiopsProtein Binding (mesh)InnateViralProtein Interaction MapsCloning, MolecularBetacoronavirus (mesh)[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/VirologyHumans (mesh)Multidisciplinary3 Good Health and Well Being (sdg)COVID-19 (mesh)COVID-19 Drug Treatment (mesh)Biological SciencesSKP Cullin F-Box Protein Ligases (mesh)PreclinicalInfection (hrcs-hc)Molecular (mesh)Infectious DiseasesDrug Repositioning (mesh)Host-Pathogen InteractionsCoronavirus Infectionssigma (mesh)Protein BindingMolecular Targeted Therapy (mesh)General Science & TechnologyAntiviral Agents (mesh)Coronaviruses Therapeutics and Interventions (rcdc)SARS-CoV-2 (mesh)Vaccine RelatedRare DiseasesViral (mesh)Protein Domains (mesh)AnimalsPreclinical (mesh)Vero CellsPandemicsCoronavirus Infections (mesh)SKP Cullin F-Box Protein LigasesBiomedical and Clinical SciencesSARS-CoV-2COVID-19COVID-19 Drug TreatmentEmerging Infectious DiseasesOrphan DrugGood Health and Well BeingHEK293 CellsProtein BiosynthesisImmunization

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 2 of COVID-19: viral–host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection

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Additional file 2 of COVID-19: viral–host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection

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Additional file 1 of The landscape of host genetic factors involved in immune response to common viral infections

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Additional file 1 of The landscape of host genetic factors involved in immune response to common viral infections

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Additional file 2 of The landscape of host genetic factors involved in immune response to common viral infections

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Additional file 2 of The landscape of host genetic factors involved in immune response to common viral infections

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Additional file 2 of Network machine learning maps phytochemically rich “Hyperfoods” to fight COVID-19

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Additional file 2 of Network machine learning maps phytochemically rich “Hyperfoods” to fight COVID-19

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Additional file 10 of Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2

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Additional file 11 of Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2

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Additional file 12 of Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2

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Additional file 1 of Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2

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Additional file 3 of Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2

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Additional file 4 of Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2

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