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Convergence of coronary artery disease genes onto endothelial cell programs

Nature(2024)10.1038/s41586-024-07022-xSource: DataRank Database

Convergence of coronary artery disease genes onto endothelial cell programs is a research paper published in Nature (2024). On theSindex it has a DataRank of 2.0. It has been cited 111 times, with 98 citing works in its 1-hop citation network.

N/A

2.0DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access111 citations · 98 citing works in its network

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Linked data & code

geo gwas refsnp uniprot doi

Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE210523

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (23 grants)Impact (FWCI 29.41)OA: greenTopics (52)IDs (PubMed, PMC, OpenAlex)Annotations (5)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 35%Citation Network 65%

Base Score Contribution

0.708

From this paper's citation signal

Citation Network Contribution

1.3

From 61 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 98 citers.

A renaissance of cerebral cavernous malformation proteins in vascular physiology
Nature Cardiovascular Research20244 citations15 referencesContributes 0.107
Trends and Projections of Burden of Ischemic Heart Disease in China Versus Other G20 Countries: A Comparative Study Based on the 2021 Global Burden of Disease Database
Global Heart202510 citations30 referencesContributes 0.080
Contributions of Common, Rare, and Somatic Genetic Variants to Incidence of Atrial Fibrillation
JAMA Cardiology20256 citations30 referencesContributes 0.065
Robust differential expression testing for single-cell CRISPR screens at low multiplicity of infection
Genome biology202423 citations50 referencesContributes 0.064
Gene regulatory network structure informs the distribution of perturbation effects
PLoS Computational Biology20259 citations41 referencesContributes 0.056

Authors (27)

Helen Kang ORCID,Shi Fang ORCID,Ramcharan Singh Angom ORCID,Vivian S. Lee ORCID,X. Rosa ORCID

Live enrichment

PubMed:38326615 PMC:PMC10921916 OpenAlex:https://openalex.org/W4391617379

NHGRI NIH HHS

Grant: K99 HG009917

NHLBI NIH HHS

Grant: U01 HL166060

NIDDK NIH HHS

Grant: K08 DK129824

NHLBI NIH HHS

Grant: R01 HL070567

NHGRI NIH HHS

Grant: UM1 HG011972

NHGRI NIH HHS

Grant: T32 HG000044

NHLBI NIH HHS

Grant: DP2 HL152423

NCI NIH HHS

Grant: R01 CA150190

Novo Nordisk Fonden

Grant: NNF21SA0072102

NHLBI NIH HHS

Grant: R01 HL159176

NHGRI NIH HHS

Grant: R00 HG009917

NHLBI NIH HHS

Grant: R01 HL140411

NHLBI NIH HHS

Grant: R01 HL164811

NIGMS NIH HHS

Grant: T32 GM087237

NHGRI NIH HHS

Grant: R35 HG011324

National Institutes of Health

Grant: 5R01HL164811-03

High-throughput cellular genetics to connect noncoding variants to coronary artery disease genes

National Institutes of Health

Grant: 5U01HL166060-04

Identifying the organotypic and disease-specific vascular cell populations by integrating single cell data with polygenic risk

National Institutes of Health

Grant: 1K99HG009917-01

Systematic mapping and prediction of gene-enhancer connections

National Institutes of Health

Grant: 1R35HG011324-01

Mapping enhancer-gene regulation in single cells to connect genetic variants to target genes and cell types

National Institutes of Health

Grant: 1UM1HG011972-01

Stanford Center for Connecting DNA Variants to Function and Phenotype

National Institutes of Health

Grant: 7K08DK129824-06

Elucidating structural, mechanistic, and allosteric determinants of mTOR Complex 2 (mTORC2) signaling.

National Institutes of Health

Grant: 5R01HL159176-04

Mapping, modeling, and manipulating 3D contacts in vascular cells to connect risk variants to disease genes

National Institutes of Health

Grant: 1DP2HL152423-01

A genetic approach to identify the common mechanisms of vascular disease

FWCI

29.41

Citation Percentile

1.0%

Influential Citations

Citation Trend

2023

2024

2025

2026

greenLicense: cc-by

repositoryhttps://dash.harvard.edu/bitstreams/8c197533-041d-49aa-9142-edd291f9120b/download

GREENhttps://dash.harvard.edu/bitstreams/8c197533-041d-49aa-9142-edd291f9120b/download

repositoryhttps://dash.harvard.edu/bitstreams/8c197533-041d-49aa-9142-edd291f9120b/download

publisherhttps://www.nature.com/articles/s41586-024-07022-x.pdf

publisherhttps://www.nature.com/articles/s41586-024-07022-x

Fields of Study

Vascular Malformations Diagnosis and TreatmentMedicineBiology0301 basic medicine03 medical and health sciencesHumansCoronary Artery DiseaseEndothelial CellsGenetic Predisposition to DiseaseGenome-Wide Association StudyHemangioma, Cavernous, Central Nervous SystemPolymorphism, Single NucleotideEpigenomicsSignal TransductionMultifactorial InheritanceCarrier ProteinsMolecular Chaperones

MeSH Terms

Carrier ProteinsCoronary Artery DiseaseHumansRisk FactorsSignal TransductionMolecular ChaperonesGenetic Predisposition to DiseaseMultifactorial InheritancePolymorphism, Single NucleotideHemangioma, Cavernous, Central Nervous SystemEndothelial CellsGenome-Wide Association StudyEpigenomics

Keywords

Genome-wide association studyBiologyGeneComputational biologyGeneticsGenetic associationBioinformaticsSingle-nucleotide polymorphismEpigenomics570Hemangioma, Cavernous, Central Nervous SystemMultifactorial InheritanceMultidisciplinary610Endothelial CellsCoronary Artery DiseasePolymorphism, Single NucleotideHumansGenetic Predisposition to DiseaseCarrier ProteinsSignal TransductionMolecular Chaperones

Sustainable Development Goals

SDG 0: Good health and well-being