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Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D

Nature Chemical Biology(2024)10.1038/s41589-024-01565-wSource: DataRank Database

Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D is a research paper published in Nature Chemical Biology (2024). On theSindex it has a DataRank of 0. It has been cited 74 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access74 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 11.88)OA: hybridTopics (47)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Ziyang Zhang ORCID,Keelan Z. Guiley ORCID,Kevan M. Shokat ORCID,Qinheng Zheng ORCID

Live enrichment

PubMed:38443470 OpenAlex:https://openalex.org/W4392460443

Damon Runyon Cancer Research Foundation

Grant: DRG-2434-21

Damon Runyon Cancer Research Foundation

Grant: DRG-2281-17

Damon Runyon Cancer Research Foundation

Grant: DRG-2399-20

National Institutes of Health

Grant: 5R01CA244550-03

Inhibitors of the G protein GNAS which drives pancreatic tumorigenesis

FWCI

11.88

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

hybridLicense: cc-by

journalhttps://www.nature.com/articles/s41589-024-01565-w.pdf

publisherhttps://www.nature.com/articles/s41589-024-01565-w.pdf

publisherhttps://www.nature.com/articles/s41589-024-01565-w

journalhttps://doi.org/10.1038/s41589-024-01565-w

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38443470

Fields of Study

Protein Kinase Regulation and GTPase SignalingSignaling Pathways in DiseaseEnzyme Structure and Function0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

AlkylationAnimalsAntineoplastic AgentsAspartic AcidHumansModels, MolecularMutationProto-Oncogene Proteins p21(ras)Crystallography, X-RayCell Line, TumorCell ProliferationMice

Keywords

MutantAlkylationStrain (injury)ChemistryCell biologyStereochemistryBiochemistryBiologyGeneCatalysisModels, MolecularAspartic AcidTumorCrystallography610MolecularAntineoplastic AgentsCrystallography, X-RayArticleCell LineProto-Oncogene Proteins p21(ras)MiceModelsCell Line, TumorMutationX-RayHumansAnimalsCell Proliferation

Sustainable Development Goals

SDG 0: Decent work and economic growth