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Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay

Communications Biology(2022)10.1038/s42003-022-03090-9Source: DataRank Database

Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay is a research paper published in Communications Biology (2022). On theSindex it has a DataRank of 0.812. It has been cited 223 times.

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0.812DataRank · unranked

Scored on demand from live citation data

Open Access223 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (2 grants)Impact (FWCI 28.00)OA: goldTopics (67)Linked Datasets (8)DataCite Reuse (8)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.812

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

This paper's DataRank is currently driven only by its base citation score. Citation network data was not refreshed for this result.

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Authors (9)

M. Narwal ORCID,Sydney A. Majowicz ORCID,Carmine Varricchio ORCID,Shay A. Toner,Carlo Ballatore ORCID

Live enrichment

PubMed:35217718 PMC:PMC8881501 OpenAlex:https://openalex.org/W4214747759

NIGMS NIH HHS

Grant: R35 GM131860

National Institutes of Health

Grant: 5R35GM131860-05

Structural study of direct associations between cellular RNA polymerase and regulatory factors during the transcription cycle

FWCI

28.00

Citation Percentile

1.0%

Influential Citations

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://www.nature.com/articles/s42003-022-03090-9.pdf

GOLDhttps://www.nature.com/articles/s42003-022-03090-9.pdf

publisherhttps://www.nature.com/articles/s42003-022-03090-9.pdf

publisherhttps://www.nature.com/articles/s42003-022-03090-9

journalhttps://doi.org/10.1038/s42003-022-03090-9

Fields of Study

Computational Drug Discovery MethodsBiochemical and Structural CharacterizationChemical synthesis and alkaloidsMedicineChemistry0301 basic medicine03 medical and health sciencesCoronavirus 3C ProteasesCoronavirus Papain-Like ProteasesDrug Evaluation, PreclinicalDrug RepositioningHEK293 CellsHumansMolecular Docking SimulationMolecular Targeted TherapySARS-CoV-2Viral Protease InhibitorsCOVID-19 Drug Treatment

MeSH Terms

Viral Protease InhibitorsSARS-CoV-2Coronavirus 3C ProteasesCoronavirus Papain-Like ProteasesCOVID-19 Drug TreatmentDrug Evaluation, PreclinicalHumansHEK293 CellsDrug RepositioningMolecular Targeted TherapyMolecular Docking Simulation

Keywords

ProteaseProteasesChemistryNelfinavirDocking (animal)BiochemistryIn silicoEnzymeBiologyVirologyVirusMedicineViral Protease InhibitorsQH301-705.5Drug Evaluation, Preclinical610Coronavirus Papain-Like ProteasesArticleHumansMolecular Targeted TherapyBiology (General)LungCoronavirus 3C ProteasesSARS-CoV-2PreventionDrug RepositioningPneumoniaPreclinicalCOVID-19 Drug TreatmentMolecular Docking SimulationInfectious DiseasesEmerging Infectious DiseasesGood Health and Well BeingHEK293 Cells5.1 PharmaceuticalsDrug EvaluationDevelopment of treatments and therapeutic interventionsInfection

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenal

10.6084/m9.figshare.20962344.v1figshare

Additional file 1 of Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenal

10.6084/m9.figshare.20962344figshare

Additional file 1 of Development of a screening platform to discover natural products active against SARS-CoV-2 infection using lung organoid models

10.6084/m9.figshare.22612700.v1figshare

Additional file 1 of Development of a screening platform to discover natural products active against SARS-CoV-2 infection using lung organoid models

10.6084/m9.figshare.22612700figshare

Additional file 1 of The role of IBV PL1pro in virus replication and suppression of host innate immune responses

10.6084/m9.figshare.24797930.v1figshare