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TREM2 Depletion in Pancreatic Cancer Elicits Pathogenic Inflammation and Accelerates Tumor Progression via Enriching IL-1β+ Macrophages

Gastroenterology(2025)10.1053/j.gastro.2025.01.244Source: DataRank Database

TREM2 Depletion in Pancreatic Cancer Elicits Pathogenic Inflammation and Accelerates Tumor Progression via Enriching IL-1β+ Macrophages is a research paper published in Gastroenterology (2025). On theSindex it has a DataRank of 0. It has been cited 37 times.

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Open Access37 citations

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Enrichment:Funding (3 grants)Impact (FWCI 15.10)OA: bronzeTopics (56)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Xinlei Sun ORCID,Hua Wang ORCID,Ignacio I. Wistuba ORCID,Huamin Wang ORCID,Anirban Maitra ORCID

Live enrichment

PubMed:39956331 PMC:PMC12103993 OpenAlex:https://openalex.org/W4407565667

National Institutes of Health

Grant: P30 CA016672

NCI NIH HHS

Grant: P50 CA221707

University of Texas MD Anderson Cancer Center

FWCI

15.10

Citation Percentile

1.0%

Citation Trend

2025

2026

bronzeLicense: https://www.elsevier.com/legal/tdmrep-license

journalhttps://www.gastrojournal.org/article/S0016-5085(25)00368-3/pdf

publisherhttps://www.gastrojournal.org/article/S0016-5085(25)00368-3/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0016508525003683?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0016508525003683?httpAccept=text/plain

journalhttps://doi.org/10.1053/j.gastro.2025.01.244

Fields of Study

Neuroinflammation and Neurodegeneration MechanismsInflammation biomarkers and pathwaysImmune cells in cancerAnimalsInterleukin-1betaPancreatic NeoplasmsReceptors, ImmunologicMembrane GlycoproteinsCarcinoma, Pancreatic DuctalTumor MicroenvironmentDisease ProgressionTumor-Associated MacrophagesMiceNLR Family, Pyrin Domain-Containing 3 ProteinMice, TransgenicHumansInflammasomesMice, KnockoutDisease Models, AnimalNF-kappa BSignal TransductionMacrophagesMice, Inbred C57BL

MeSH Terms

NLR Family, Pyrin Domain-Containing 3 ProteinTumor-Associated MacrophagesAnimalsDisease Models, AnimalHumansMacrophagesMembrane GlycoproteinsMice, Inbred C57BLMice, TransgenicPancreatic NeoplasmsReceptors, ImmunologicSignal TransductionNF-kappa BMice, KnockoutDisease ProgressionCarcinoma, Pancreatic DuctalMiceInterleukin-1betaInflammasomesTumor Microenvironment

Keywords

InflammationPancreatic cancerCancer researchTREM2CancerMedicineImmunologyInternal medicineMicrogliaMacrophagesGenetically Engineered Mouse ModelsTumor Immune MicroenvironmentSingle-cell Rna-sequencing

Sustainable Development Goals

SDG 0: Good health and well-being