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Disruption of electrostatic contacts in the HNH nuclease from a thermophilic Cas9 rewires allosteric motions and enhances high-temperature DNA cleavage

The Journal of Chemical Physics(2022)10.1063/5.0128815Source: DataRank Database

Disruption of electrostatic contacts in the HNH nuclease from a thermophilic Cas9 rewires allosteric motions and enhances high-temperature DNA cleavage is a research paper published in The Journal of Chemical Physics (2022). On theSindex it has a DataRank of 0. It has been cited 17 times.

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Enrichment:Funding (17 grants)OA: bronzeTopics (13)IDs (PubMed, PMC)Annotations (1)

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Authors (9)

Carmelissa Norbrun ORCID,Jinping Luo ORCID,Chinmai Pindi ORCID,Souvik Sinha ORCID,Alexandra M. D’Ordine ORCID

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PubMed:36546784 PMC:PMC9759293

National Institutes of Health

Grant: T32 GM077995

National Institutes of Health

Grant: T32 GM139793

National Institutes of Health

Grant: P30 GM133893

National Institutes of Health

Grant: R01 GM136815

National Institutes of Health

Grant: R01 GM 141329

National Science Foundation

Grant: MCB 2143760

National Science Foundation

Grant: CHE 1905374

National Science Foundation

Grant: 2040433

Graduate Research Fellowship Program (GRFP)

National Energy Research Scientific Computing Center

Grant: M3807

XSEDE

Grant: TG-MCB 160059

National Institutes of Health

Grant: 5P30GM133893-04

The Center for Biomolecular Structure at NSLS-II

National Institutes of Health

Grant: 3R01GM141329-05S1

Investigating the metal-dependent function, allostery and inhibition of CRISPR-Cas9

National Science Foundation

Grant: 2143760

CAREER: Molecular Resolution of Long-range Allostery in CRISPR-Cas9

National Institutes of Health

Grant: 5R01GM136815-04

Studies of Allostery between Multi-domain Proteins and Nucleic Acid Complexes

National Institutes of Health

Grant: 5T32GM077995-03

Predoctoral Training Program in Trans-Disciplinary Pharmacological Sciences

National Science Foundation

Grant: 1905374

Mechanistic investigation of DNA cleavage and specificity in CRISPR-Cas9

National Institutes of Health

Grant: 5T32GM139793-03

Interdisciplinary training in pharmacological sciences

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publisherhttps://aip.scitation.org/doi/pdf/10.1063/5.0128815

publisherhttps://pubs.aip.org/aip/jcp/article-pdf/doi/10.1063/5.0128815/16557980/225103_1_online.pdf

repositoryhttps://www.osti.gov/servlets/purl/2422932

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9759293

https://doi.org/10.1063/5.0128815

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

TemperatureDNA CleavageStatic ElectricityCRISPR-Cas SystemsCRISPR-Associated Protein 9

Keywords

CRISPR-Associated Protein 9Static ElectricityTemperatureCRISPR-Cas SystemsDNA Cleavage

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Disruption of electrostatic contacts in the HNH nuclease from a thermophilic Cas9 rewires allosteric motions and enhances high-temperature DNA cleavage

FAIR Checklist

Authors (9)

Funding (17 grants)

Open Access

Topics

Annotations (Europe PMC)

Related Papers (10)