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A common polymorphism in the mechanosensitive ion channel PIEZO1 is associated with protection from severe malaria in humans

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.1919843117Source: DataRank Database

A common polymorphism in the mechanosensitive ion channel PIEZO1 is associated with protection from severe malaria in humans is a research paper published in Proceedings of the National Academy of Sciences (2020). On theSindex it has a DataRank of 2.8. It has been cited 66 times, with 61 citing works in its 1-hop citation network.

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2.8DataRank · unranked

Scored on demand from live citation data

Open Access66 citations · 61 citing works in its network

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Linked data & code

refsnp refseq

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (9 grants)Impact (FWCI 4.54)OA: hybridTopics (60)Linked Datasets (4)DataCite Reuse (4)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 22%Citation Network 78%

Base Score Contribution

0.631

From this paper's citation signal

Citation Network Contribution

2.2

From 55 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 61 citers.

Concurrent PIEZO1 activation and ATP2B4 blockade effectively reduce the risk of cerebral malaria and inhibit in vitro Plasmodium falciparum multiplication in red blood cells
Genes & Diseases20237 citations5 referencesContributes 0.416
Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study
Journal of Human Genetics202113 citations8 referencesContributes 0.330
“Iron”ing out hemophagocytosis through PIEZO1
Cell20216 citations11 referencesContributes 0.177
Nobel prize in physiology or medicine 2021, receptors for temperature and touch: Implications for hematology
American Journal of Hematology202111 citations18 referencesContributes 0.138
Missense mutations in PIEZO1, which encodes the Piezo1 mechanosensor protein, define Er red blood cell antigens
Blood202231 citations40 referencesContributes 0.087

Authors (8)

Natasha Purington ORCID,Emily R. Ebel ORCID,Bikash Shakya ORCID,Marilou Tétard ORCID,Peter G. Kremsner ORCID

Live enrichment

PubMed:32265284 PMC:PMC7183233 OpenAlex:https://openalex.org/W3014697035

Doris Duke Charitable Foundation

Grant: 2016098

HHS | NIH | NIH Office of the Director

Grant: DP2HL137186

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Grant: 1T32DK098132-01A1

Training in Pediatric Nonmalignant Hematology and Stem Cell Biology

NCATS NIH HHS

Grant: UL1 TR001085

NCATS NIH HHS

Grant: UL1 TR003142

NIDDK NIH HHS

Grant: T32 DK098132

Wellcome Trust

Grant: unidentified

unidentified

National Institutes of Health

Grant: 1DP2HL137186-01

Identifying critical erythrocyte host factors for Plasmodium falciparum malaria

National Institutes of Health

Grant: 5UL1TR001085-05

Spectrum Stanford Center for clinical and Translational Research and Education

FWCI

4.54

Citation Percentile

1.0%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://www.pnas.org/content/pnas/117/16/9074.full.pdf

publisherhttps://www.pnas.org/content/pnas/117/16/9074.full.pdf

publisherhttp://www.pnas.org/syndication/doi/10.1073/pnas.1919843117

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.1919843117

journalhttps://doi.org/10.1073/pnas.1919843117

Fields of Study

Erythrocyte Function and PathophysiologyHemoglobinopathies and Related DisordersBlood properties and coagulation0301 basic medicine03 medical and health sciences

MeSH Terms

Gain of Function MutationAnimalsChildChild, PreschoolDNA Mutational AnalysisErythrocytesFemaleGabonHumansInfantIon ChannelsMalePlasmodium falciparumPolymorphism, GeneticSickle Cell TraitProtozoan ProteinsCase-Control StudiesMalaria, FalciparumDisease ResistanceProtective Factors

Keywords

PIEZO1Mechanosensitive channelsMalariaBiologyPlasmodium falciparumMutantAlleleImmunologySickle cell traitGeneticsCerebral MalariaIon channelMedicineInternal medicineGeneGenetic Association StudyMaleErythrocytesPolymorphism, GeneticDNA Mutational AnalysisProtozoan ProteinsInfantBiological SciencesProtective FactorsIon ChannelsCase-Control StudiesChild, PreschoolGain of Function MutationAnimalsHumansFemaleGabonMalaria, FalciparumChildDisease Resistance

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of Microglial amyloid beta clearance is driven by PIEZO1 channels

10.6084/m9.figshare.20080821.v1figshare

Additional file 1 of Microglial amyloid beta clearance is driven by PIEZO1 channels

10.6084/m9.figshare.20080821figshare

Additional file 1 of Blockage of mechanosensitive Piezo1 channel alleviates the severity of experimental malaria-associated acute lung injury

10.6084/m9.figshare.26675453.v1figshare

Additional file 1 of Blockage of mechanosensitive Piezo1 channel alleviates the severity of experimental malaria-associated acute lung injury

10.6084/m9.figshare.26675453figshare