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The Legionella kinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.2000497117Source: DataRank Database

The Legionella kinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation is a research paper published in Proceedings of the National Academy of Sciences (2020). On theSindex it has a DataRank of 0.819. It has been cited 27 times, with 14 citing works in its 1-hop citation network.

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0.819DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access27 citations · 14 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

PDB6MCQ 6MCP

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 0.81)OA: greenTopics (91)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 61%Citation Network 39%

Base Score Contribution

0.500

From this paper's citation signal

Citation Network Contribution

0.319

From 11 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 14 citers.

Activation of the Legionella pneumophila LegK7 Effector Kinase by the Host MOB1 Protein
Journal of Molecular Biology202011 citations34 referencesContributes 0.073
Pasteurella multocida activates Rassf1-Hippo-Yap pathway to induce pulmonary epithelial apoptosis
Veterinary Research202417 citations49 referencesContributes 0.059
Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila
Nature Communications202216 citations56 referencesContributes 0.051
YAP promotes cell-autonomous immune responses to tackle intracellular Staphylococcus aureus in vitro
Nature Communications202224 citations71 referencesContributes 0.045
Phosphorylation of caspases by a bacterial kinase inhibits host programmed cell death
Nature Communications202413 citations80 referencesContributes 0.033

Authors (9)

Ksenia Beyrakhova ORCID,Caishuang Xu,Michal T. Boniecki ORCID,Mitchell H. Lee,Chisom Onu ORCID

Live enrichment

PubMed:32513747 PMC:PMC7322029 OpenAlex:https://openalex.org/W3033677422

HHS | National Institutes of Health

Grant: 1ZIAHD008893-09

Deciphering microbial virulence mechanisms during Legionella pneumophila infection

Gouvernement du Canada | Canadian Institutes of Health Research

Grant: MOP-48370

Wayne State University

Grant: Startup funding

Intramural NIH HHS

Grant: ZIA HD008893

Canadian Institutes of Health Research

Grant: unidentified

unidentified

FWCI

0.81

Citation Percentile

0.7%

Citation Trend

2020

2021

2022

2023

2024

2025

greenLicense: https://www.pnas.org/site/aboutpnas/licenses.xhtml

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7322029

publisherhttp://www.pnas.org/syndication/doi/10.1073/pnas.2000497117

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2000497117

journalhttps://doi.org/10.1073/pnas.2000497117

Fields of Study

Hippo pathway signaling and YAP/TAZCell death mechanisms and regulationCellular transport and secretion0301 basic medicine0303 health sciences03 medical and health sciencesAdaptor Proteins, Signal TransducingAllosteric RegulationAnimalsBacterial ProteinsCell Cycle ProteinsHEK293 CellsHost-Pathogen InteractionsHumansIntracellular Signaling Peptides and ProteinsLegionella pneumophilaLegionnaires' DiseaseMacrophages, AlveolarMiceMolecular Dynamics SimulationMolecular MimicryPhosphorylationProtein BindingProtein KinasesRAW 264.7 CellsRecombinant ProteinsSignal TransductionTranscription FactorsYAP-Signaling Proteins

MeSH Terms

RAW 264.7 CellsYAP-Signaling ProteinsAllosteric RegulationAnimalsBacterial ProteinsHumansLegionnaires' DiseasePhosphorylationProtein BindingProtein KinasesRecombinant ProteinsTranscription FactorsSignal TransductionMacrophages, AlveolarLegionella pneumophilaMolecular MimicryCell Cycle ProteinsIntracellular Signaling Peptides and ProteinsAdaptor Proteins, Signal TransducingMiceHost-Pathogen InteractionsMolecular Dynamics SimulationHEK293 Cells

Keywords

PhosphorylationScaffold proteinScaffoldSubstrate (aquarium)Cell biologyAllosteric regulationKinaseChemistryProtein kinase AProtein phosphorylationBiochemistryBiologyComputer scienceSignal transductionEnzymeEcologyCrystal structureMicrobial pathogenType Iv Secretion SystemMst1/2Translocated EffectorMolecular MimicryIntracellular Signaling Peptides and ProteinsCell Cycle ProteinsMolecular Dynamics SimulationRecombinant ProteinsLegionella pneumophilaMiceHEK293 CellsRAW 264.7 CellsBacterial ProteinsHost-Pathogen InteractionsMacrophages, AlveolarAnimalsHumansLegionnaires' DiseaseProtein KinasesAdaptor Proteins, Signal TransducingProtein Binding