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Impairment of the neurotrophic signaling hub B-Raf contributes to motoneuron degeneration in spinal muscular atrophy

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2007785118Source: DataRank Database

Impairment of the neurotrophic signaling hub B-Raf contributes to motoneuron degeneration in spinal muscular atrophy is a research paper published in Proceedings of the National Academy of Sciences (2021). On theSindex it has a DataRank of 0.676. It has been cited 26 times, with 13 citing works in its 1-hop citation network.

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0.676DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access26 citations · 13 citing works in its network

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gen reactome

Data availability

Repositories this paper deposited data in (declared in PubMed).

figshare10.6084/m9.figshare.13668872

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 2.33)OA: bronzeTopics (61)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 73%Citation Network 27%

Base Score Contribution

0.494

From this paper's citation signal

Citation Network Contribution

0.182

From 9 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 13 citers.

Neuromuscular denervation and deafferentation but not motor neuron death are disease features in the Smn2B/- mouse model of SMA
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Frontiers in Cellular Neuroscience20228 citations64 referencesContributes 0.034
Targeted antisense oligonucleotide treatment rescues developmental alterations in spinal muscular atrophy organoids
Nature Communications20257 citations79 referencesContributes 0.026
High Concentration of an ISS-N1-Targeting Antisense Oligonucleotide Causes Massive Perturbation of the Transcriptome
International Journal of Molecular Sciences202118 citations145 referencesContributes 0.020

Authors (18)

Federica Cieri ORCID,Pamela Santonicola ORCID,Ines Tapken ORCID,Tobias Schüning ORCID,Michela Taiana ORCID

Live enrichment

PubMed:33931501 PMC:PMC8106332 OpenAlex:https://openalex.org/W3157147848

Deutsche Muskelstiftung

Grant: SMAPERIPHERAL

SMA Europe

Grant: Postdoctoral Fellowship

SMA Europe

Grant: SMATARGET

Italian Telethon Foundation

Grant: GGP16203

NIH HHS

Grant: P40 OD010440

National Institutes of Health

Grant: 1P40OD010440-01

Caenorhabditis Genetics Center

FWCI

2.33

Citation Percentile

0.9%

Citation Trend

2021

2022

2023

2024

2025

bronzeLicense: https://www.pnas.org/site/aboutpnas/licenses.xhtml

journalhttps://www.pnas.org/content/pnas/118/18/e2007785118.full.pdf

publisherhttps://www.pnas.org/content/pnas/118/18/e2007785118.full.pdf

publisherhttp://www.pnas.org/syndication/doi/10.1073/pnas.2007785118

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2007785118

journalhttps://doi.org/10.1073/pnas.2007785118

Fields of Study

Neurogenetic and Muscular Disorders ResearchRNA modifications and cancerRNA Research and Splicing0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

AnimalsDisease Models, AnimalFibroblastsGene Expression RegulationHumansMotor NeuronsMuscular Atrophy, SpinalNerve DegenerationSpinal CordSignal TransductionCaenorhabditis elegansCaenorhabditis elegans Proteinsraf KinasesProto-Oncogene Proteins B-raf14-3-3 ProteinsMiceSurvival of Motor Neuron 1 Protein

Keywords

SMA*Spinal muscular atrophySMN1BiologyNeuroscienceMotor neuronSignal transductionNeurotrophic factorsMAPK/ERK pathwayNeurodegenerationSpinal cordCell biologyMedicineGeneticsGeneDiseaseInternal medicineReceptorSMA14-3-3RafNeurotrophic SignalingProto-Oncogene Proteins B-rafMuscular Atrophy, SpinalMiceAnimalsHumansspinal musCaenorhabditis elegansCaenorhabditis elegans ProteinsMotor NeuronsFibroblastsSurvival of Motor Neuron 1 ProteinDisease Models, Animal14-3-3 ProteinsGene Expression RegulationNerve Degenerationraf Kinases

Sustainable Development Goals

SDG 0: Life in Land