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Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.2009838117Source: DataRank Database

Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria is a research paper published in Proceedings of the National Academy of Sciences (2020). On theSindex it has a DataRank of 3.6. It has been cited 159 times, with 100 citing works in its 1-hop citation network.

N/A

3.6DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access159 citations · 100 citing works in its network

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Linked data & code

Data associated with 'Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria' · Dryad

bioproject doi

Data availability

Repositories this paper deposited data in (declared in PubMed).

Dryad10.5061/dryad.5mkkwh72q

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (14 grants)Impact (FWCI 7.82)OA: greenTopics (46)Linked Datasets (1)DataCite Reuse (1)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 21%Citation Network 79%

Base Score Contribution

0.761

From this paper's citation signal

Citation Network Contribution

2.8

From 100 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 100 citers.

Long non‐coding RNA Opa interacting protein 5‐antisense RNA 1 promotes mitochondrial autophagy and protects SH‐SY5Y cells from 1‐methyl‐4‐phenylpyridine‐induced damage by binding to microRNA‐137 and upregulating NIX
The Kaohsiung Journal of Medical Sciences202218 citations32 referencesContributes 0.092
Metformin Protects against Spinal Cord Injury and Cell Pyroptosis via AMPK/NLRP3 Inflammasome Pathway
Analytical Cellular Pathology202230 citations39 referencesContributes 0.088
Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome
Nature Communications2021217 citations64 referencesContributes 0.084
Ginsenoside Rk1 prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s disease via activating silence information regulator 3-mediated Nrf2/HO-1 signaling pathway
Human & Experimental Toxicology202318 citations35 referencesContributes 0.084
Baicalein Mediates Mitochondrial Autophagy via miR-30b and the NIX/BNIP3 Signaling Pathway in Parkinson’s Disease
Biochemistry Research International202130 citations41 referencesContributes 0.084

Authors (8)

Salman Sohrabi ORCID,Rachel Kaletsky ORCID,William Keyes,Alp Tartici,Vrinda Kalia ORCID

Live enrichment

PubMed:33024014 PMC:PMC7585014 OpenAlex:https://openalex.org/W3091839870

HHS | NIH | National Institute on Aging

Grant: F32AG062036

HHS | NIH | National Institute of Environmental Health Sciences

Grant: U2CES030163

HHS | NIH | National Institute of Environmental Health Sciences

Grant: R01ES023839

HHS | NIH | National Institute of General Medical Sciences

Grant: 5DP1GM119167

Glenn Foundation for Medical Research

Grant: CNV1001899

NIH HHS

Grant: P40 OD010440

NIGMS NIH HHS

Grant: DP1 GM119167

NIA NIH HHS

Grant: R01 AG034446

National Institutes of Health

Grant: 1P40OD010440-01

Caenorhabditis Genetics Center

National Institutes of Health

Grant: 5DP1GM119167-02

Toward the Tissue-ome: A Map of the C. elegans Cell-specific Transcriptome

National Institutes of Health

Grant: 5U2CES030163-03

Mega-scale Identification tools for xenobiotic metabolism

National Institutes of Health

Grant: 3R01ES023839-04S1

Vesicular modulation of dopamine neuron toxicity

National Institutes of Health

Grant: 1F32AG062036-01A1

The role of branched chain amino acid metabolism in the regulation of lifespan and cognitive decline

Howard Hughes Medical Institute

FWCI

7.82

Citation Percentile

1.0%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

greenLicense: CC BY NC ND

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7585014

publisherhttp://www.pnas.org/syndication/doi/10.1073/pnas.2009838117

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2009838117

journalhttps://doi.org/10.1073/pnas.2009838117

Fields of Study

Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and PathologyMetabolism and Genetic Disorders0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Amino Acids, Branched-ChainAnimalsDisease Models, AnimalMetforminMitochondriaNeuronsParkinson DiseasePhenotypeCaenorhabditis elegansCaenorhabditis elegans Proteins

Keywords

MetforminDiseaseNeurodegenerationMitochondrionParkinson's diseaseMechanism (biology)MedicineDiabetes mellitusPhenotypeNeuroscienceNeuroprotectionBioinformaticsPharmacologyBiologyInternal medicineEndocrinologyCell biologyGeneticsGeneMitochondriaCaenorhabditis elegansParkinson’s DiseaseBranched-chain Amino Acid MetabolismNeuronsParkinson DiseaseBiological SciencesDisease Models, AnimalAnimalsCaenorhabditis elegans ProteinsAmino Acids, Branched-Chain

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Data associated with 'Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria'

10.5061/dryad.5mkkwh72qDryad